Newborn Adipokines and Birth Outcomes

Abstract

Background Adipokines can serve as a measure of adipose tissue activity. Although birthweight correlates with neonatal adiposity, findings for cord blood levels of adipokines and birth outcomes have been conflicted. Therefore, we determined the cross-sectional associations between adipokines measured in newborn dried blood spots (DBS) and birth outcomes. Methods The Upstate KIDS study enrolled mothers and infants from 2008 to 2010. Among infants whose parents consented to use of residual DBS from Newborn Screening, 2397 singletons and 1240 twins had adipokine measurements from the Human Obesity Panel (R&D Systems) by Luminex. Odds ratios were estimated by multivariable logistic regression for risk of birth outcomes of preterm delivery (<37 weeks for singletons, <32 for twins) and small for gestational age (SGA <10th for singletons and <3rd for twins age and sex specific percentiles) by adipokine quintiles. Generalized estimating equations were applied to account for correlations between twins. Results Singletons in the lowest compared to the highest quintile of adiponectin were more likely preterm (adjusted odds ratio 3.26; 95% confidence interval: 1.99-5.34), and SGA (1.81; 1.18-2.77). Similar associations were observed among twins. Resistin was associated with preterm birth (Q1 vs Q5: 2.08; 1.20-3.62) only among singletons. Adipsin had inconsistent associations after adjustment. Conclusions This large population based study demonstrates that newborn DBS measured adipokines are associated with birth outcomes, particularly preterm birth and SGA among those with lower adiponectin levels regardless of plurality.

Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study

“…Mean cord adiponectin levels were significantly different across groups defined by gestational age at birth, with early preterm children (8.29 μg/mL) having the lowest levels, followed by late preterm (11.51 μg/mL) and term infants (16.90 μg/mL) (p value <0.001). Consistent with other studies (Lenz and Diamond 2012; Mantzoros et al 2009; Nakano et al 2013; Yeung et al 2015; Martos-Moreno et al 2009; Hellgren et al 2015), we observed that cord adiponectin was associated with the duration of gestation (Online Resource Table 1). Figure 1 shows the distribution of cord adiponectin by preterm status.…”

Enhancement of immune response mediated by oropharyngeal colostrum administration in preterm neonates

“…In the same way as lactoferrin does, resistin decreases progressively in maternal milk . Resistin is a metabolic hormone that plays important roles in regulating energy homeostasis and carbohydrate/lipid metabolism, is mainly secreted by adipocytes, impairs glucose homeostasis, and opposes the action of insulin in peripheral tissues . On the other hand, pro‐inflammatory cytokines IL‐1β, TNF‐α, and IL‐6 stimulate the production of resistin .…”

Concentrations of immune marker in newborn dried blood spots and early childhood development: Results from the Upstate KIDS Study

“…NDBS were stored at 4°C and later retrieved for blood spot analyses. Punches of the residual spots were extracted and handled in a similar manner as previously described . Briefly, blood spots were extracted overnight (18‐20 hours) at 4°C with 60 μL of elution buffer in low‐binding 96‐well round bottom plates (catalogue #1830‐9600, USA Scientific, Ocala, FL) on an orbital shaker (Titer Plate Shaker, model # 1830‐9600, USA Scientific, Ocala, FL) at 500 ± 50 rpm.…”