Association of a PIT1 gene polymorphism with growth hormone mRNA levels in pig pituitary glands

Franco, M. M.; Antunes, Robson Carlos; Oliveira, Katiana Mello de; Pereira, Cícero Donizete; Biase, Fernando H.; Nunes, Francis Morais Franco; Goulart, Luiz Ricardo

doi:10.1590/s1415-47572005000100003

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…The results of the present study are inconsistent with previous studies on the relationship between PIT1 polymorphisms and growth traits. Final body weights were not significantly different between pigs with AA (92.60kg) and BB (89.23kg) genotypes in Landrace pigs (Franco et al, 2005a). Another study by Franco et al (2005b) found Landrace pigs carrying the genotype AA had no differences in their ADG (868g) compared to pigs with the genotype BB (873g).…”

Section: Discussionmentioning

confidence: 85%

“…For PIT1, the allele A frequency (0.247) was lower than that of allele B (0.753) for a Pietrain pig population, however, the frequencies of allele A for Landrace (0.662) and Large White (0.835) were higher than that of B, respectively 0.338 and 0.165 (Piórkowska et al, 2013). Similarly, Ha Xuan Bo et al (2022) the allele A frequency in Landrace pigs (0.878) was higher than that of B (0.122) (Franco et al, 2005a;. In contrast, the allele A frequency of the PIT1 gene in a Pietrain pig population (0.393) was lower than that of allele B (0.607) (Brunsch et al, 2002).…”

Section: Discussionmentioning

confidence: 95%

“…Growth, carcass performance, and meat quality are influenced by the PIT1 (pituitary specific transcription factor-1) gene. Pigs carrying either the AB or BB genotype have been shown to have higher carcass weights than those carrying the genotype AA (Yu et al, 1995;Brunsch et al, 2002;Franco et al, 2005a;2005b;Piórkowska et al, 2013;Kim et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Additive and Dominance Effects of MC4R and PIT1 Polymorphisms on Production and Carcass Traits in Duroc Pigs

Bo¹,

Hùng²,

Manh³

et al. 2022

vjas

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This study aimed to estimate the allelic and genotypic frequencies of single nucleotide polymorphisms (SNPs) of MC4R (melanocortin-4-receptor gene) and PIT1 (pituitary specific transcription factor-1) genes, and their additive dominance genetic effects on production and carcass traits in Duroc pigs. A total of 2170 tail tissue samples (1728 gilts and 442 male pigs) were collected from Dabaco Nucleus Breeding Pig Company, Bac Ninh province, Vietnam from January 2017 to June 2020. Polymorphisms in the MC4R and PIT1 genes were detected using the PCR-RFLP method. For MC4R, the frequencies of alleles A and G were 0.430 and 0.570, respectively. For PIT1, the frequencies of alleles A and B were 0.460 and 0.540, respectively. The genotype frequency distribution of the MC4R gene was in Hardy-Weinberg equilibrium (P = 0.375), but the genotype frequency distribution of PIT1 (P <0.001) was not. The MC4R and PIT1 polymorphisms were significantly associated with final body weight and average daily gain (P <0.001). Significant additive effects were also found (P <0.05) for the two traits. The selection of individuals with the MC4R genotype AA and PIT1 genotype AA could improve final body weight and average daily gain in Duroc pigs.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Additive and Dominance Effects of MC4R and PIT1 Polymorphisms on Production and Carcass Traits in Duroc Pigs

Bo¹,

Hùng²,

Manh³

et al. 2022

vjas

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“…Pit-1 regulates the immune system in the body through growth hormone cascade. Earlier studies revealed that growth hormone expression is directly controlled by pit-1 factor, which normally binds to the promoter of growth hormone gene for activating the expression of the gene (Hashimoto et al 2003;Franco et al 2005). Growth hormone stimulates proliferation of T and B cells and synthesis of immunoglobulin, besides enhancing the maturation of myeloid progenitor cells (Meazza et al 2004).…”

Section: Resultsmentioning

confidence: 99%

Polymorphism at exon 1 of pit-1 gene and its association with immunocompetence traits in layer chicken

Bhattacharya

Priyanka

Chatterjee

et al. 2011

Journal of Applied Animal Research

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A study was designed to explore genetic variability of partial promoter and exon 1 of pit-1 gene and its effect on immune competence traits in White Leghorn chicken. Single stranded conformation polymorphism technique followed by sequencing was employed to detect polymorphism of the gene. Three genotypes (AA, AB and BB) were observed in White Leghorn chicken where two alleles (A and B) were found. AB genotype and A allele were predominant in the population. Different demographic parameters estimated in the White Leghorn chicken lines indicated the presence of genetic divergence among the lines. The pit-1 mRNA expression varied among the genotypes where genotype BB expressed higher than genotype AA and AB. The genotypes as well as alleles showed significant effect (P B 0.05) on sheep RBC titre in White Leghorn chicken.

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A critical analysis of production-associated DNA polymorphisms in the genes of cattle, goat, sheep, and pig

2008

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Increasing productivity is one of the main objectives in animal production. Traditional breeding methods have led to increased gains in some traits but gains are not easily attainable in traits with low heritabilities. Exploiting the genetic variations underlying desired phenotypes is the goal of today's animal producers. Such positive genetic variants must, however, be known before possible application. Consequently, candidate genes of traits of interest have been searched for possible relationships with such traits or to explain reported quantitative trait loci (QTL) for such traits. DNA variants or polymorphisms have been identified in many such genes and their relationships with production traits determined. However, only a few genes have been evaluated, given the wealth of information on reported QTL for production traits, and in most cases genes are only partially investigated. This review presents available information on DNA variants for production traits and discusses steps that are required for effective utilization of this information for successful marker-assisted selection programs.

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Association of a PIT1 gene polymorphism with growth hormone mRNA levels in pig pituitary glands

Cited by 5 publications

References 17 publications

Additive and Dominance Effects of MC4R and PIT1 Polymorphisms on Production and Carcass Traits in Duroc Pigs

Additive and Dominance Effects of MC4R and PIT1 Polymorphisms on Production and Carcass Traits in Duroc Pigs

Polymorphism at exon 1 of pit-1 gene and its association with immunocompetence traits in layer chicken

A critical analysis of production-associated DNA polymorphisms in the genes of cattle, goat, sheep, and pig

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