Association of -108 C>T PON1 polymorphism with polycystic ovary syndrome

Abstract

Abstract. Polycystic ovary syndrome (PCOS) is possibly the most common endocrine disorder in premenopausal women. In this study, we aimed to investigate the association of the -108 C>T polymorphism in the PON1 gene, which encodes the antioxidant enzyme paraoxonase-1, with PCOS. A total of 118 women with PCOS and 108 control subjects were included in this case-control study. The PON1 polymorphism was genotyped, biochemical and clinical parameters were determined and the correlations between the parameters were statistically evaluated. The differences in the PON1 allele and genotype distributions between PCOS patients and controls did not reach a statistical significance. The serum fasting glucose (GLU) levels did not differ significantly between the PCOS patients and the controls. However, the serum fasting insulin (INS) concentration, INS̸GLU ratio and homeostasis model assessment (HOMA) index, although within the normal range, were significantly higher in the PCOS group. When considering PCOS patients and controls as separate groups or as a single group of patients, none of the analyzed biochemical or clinical parameters were found to be significantly correlated with the PON1 polymorphism. Therefore, the -108 C>T PON1 polymorphism was not found to be significantly associated with the presence of PCOS or with its particular clinical and biochemical characteristics in non-insulin resistant, non-obese patients.

The association between paraoxonase 1 gene polymorphisms and polycystic ovarian syndrome

“…Human serum PON1 levels and activity display an up to 40-fold interindividual variability and are genetically associated with a single nucleotide polymorphism (SNP) in the PON1 gene. Some studies investigated the association of PON1 polymorphisms with PCOS risk (4)(5)(6)(7)(8)(9)(10)(11). However, the result was still inconsistent.…”

Paraoxonase single nucleotide variants show associations with polycystic ovary syndrome: a meta-analysis

“…Figure 1 outlines the study selection process in a flowchart following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (Table S2). Twenty-one citations from the initial search were filtered to yield 12 articles for inclusion [38][39][40][41][42][43][44][45][46][47][48][49], all of which examined SNVs in PON1 except Liu et al [48], which focused on rs7493 SNV in PON2.…”

“…Gene-gene and gene-environment interactions have been reported to have roles in the associations of PON variants with PCOS. All 12 included articles acknowledged the role of environment but haplotype analysis was addressed in only four (33%) of the component studies [38,45,47,49]. In addition to PON, one article [48] examined SNVs in another gene (superoxide dismutase-2).…”