Association of PON1 gene polymorphisms with polycystic ovarian syndrome risk: a meta-analysis of case–control studies

Liao, Dan; Yu, Hongsheng; Han, Lin; Zhong, Changqing; Ran, Xiaodan; Wang, D.; Mo, Lijun

doi:10.1007/s40618-018-0866-4

Cited by 7 publications

(11 citation statements)

References 40 publications

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“…GWAS has been carried out in Han Chinese and European ancestry women and reproduced identifying 16 loci ( Chen et al, 2011 , Shi et al, 2012 , Hayes et al, 2015 , Day et al, 2015 ). Meta-analysis studies performed in PCOS with molecular case-control studies have been documented with both positive and negative factors ( Cheng et al, 2019 , Li et al, 2020 , Liang et al, 2019 , Liao et al, 2018 , Liu et al, 2017 , Liu and Fat, 2017 , Niu et al, 2018 , Pabalan et al, 2016 , Park et al, 2019 , Tiongco et al, 2019 , Zhu et al, 2019 , Zou et al, 2019 ). Day et al ( Day et al, 2018 ) from his large meta -analysis and GWAS studies; identified three novel loci such as PLGRKT ; ZBTB16 and MAPRE1 and also replication of 11 loci previously documented.…”

Section: Genetics Of Pcosmentioning

confidence: 99%

Genetic construction between polycystic ovarian syndrome and type 2 diabetes

Bogari

2020

Saudi Journal of Biological Sciences

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Polycystic ovarian syndrome (PCOS) in reproductive-aged women is identified to be one of the endocrine disorders. This heterogeneous disorder is categorized through oligo-anovulation and hyperandrogenemia. National institutes of health and Rotterdam criterions were used to diagnose PCOS women. Type 2 Diabetes (T2D) is one of the complications in PCOS which is connected through insulin resistance (IR), which is a condition in which liver, muscles and fat infrequently respond to the hormones, and this leads to extreme IR and consequently leads to T2D disease. PCOS is inherited by the autosomal dominant mode of inheritance and may also with the different intricate patterns. Till now, many studies have been performed in PCOS with the genes identified by T2D and till now no studies have shown the similar genetic association and pathophysiology between both the diseases. So, the current review aims to investigate the genetic relation between PCOS and T2D and why both the diseases cannot be reverted. In this review, published data were screened with the T2D related genes and single nucleotide polymorphisms in PCOS women. The case-control, hospital-based and meta -analysis molecular studies disclosed both positive and negative connotations. Genetically, no relationship has been established between PCOS and T2D. Maximum studies have shown as PCOS women had developed T2D later in life because as a risk-factor, but none of the studies documented T2D women having developed PCOS as a risk factor. Apart from this, the disease PCOS is developed in women with reproductive age and T2D develops in both the men and women during adulthood. This review concludes as there is a genetic relation only in between PCOS and T2D, but not with T2D to PCOS and further it cannot be explicitly reverted from T2D to PCOS.

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Section: Genetics Of Pcosmentioning

confidence: 99%

Genetic construction between polycystic ovarian syndrome and type 2 diabetes

Bogari

2020

Saudi Journal of Biological Sciences

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“…All 21 systematic reviews included a meta-analysis and were based on case-control or cross-sectional primary studies. Nineteen systematic reviews investigated SNPs [33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51]. The remaining two systematic reviews investigated CAG repeat length or tandem repeats respectively [52,53].…”

Section: Resultsmentioning

confidence: 99%

“…The remaining two systematic reviews investigated CAG repeat length or tandem repeats respectively [52,53]. Candidate genes focused on three main aspects of PCOS pathophysiology: metabolic dysfunction, [33,35,38,39,40,41,42,43,44,48,49,50,52], imbalances in androgens and gonadotrophins [36,37,51,53], and inflammation [34,45,46,47].…”

Section: Resultsmentioning

confidence: 99%

“…Three SNPs in Calpain-10 were associated with increased risk of PCOS, with ancestry again playing a major role, with a significant association only found in a mixed population of “Asian” ancestry [40]. The two SNPs in PON1 were associated with increased risk of PCOS overall but, again, this was restricted to specific ancestries and diagnostic criteria [49]. Two SNPs in DENND1A (rs10818854 and rs10986105) were associated with increased risk of PCOS [48], while the SNP (rs2479106) in DENND1A was only associated in the women of mixed “Asian” ancestry [48].…”

Section: Resultsmentioning

confidence: 99%

“…The remaining 11 systematic reviews accepted diagnostic criteria consistent with the most inclusive Rotterdam diagnostic criteria. However, it should be noted that some of the primary studies included in these systematic reviews selectively recruited specific phenotypes (such as the National Institute of Health (NIH), or Androgen Excess PCOS (AEPCOS) phenotypes) [33,34,35,37,40,42,43,46,48,49,53] potentially indicating a bias towards the more severe phenotypes in PCOS.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

The Genetics of Polycystic Ovary Syndrome: An Overview of Candidate Gene Systematic Reviews and Genome-Wide Association Studies

Hiam

Moreno-Asso

Teede

et al. 2019

JCM

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Polycystic Ovary Syndrome (PCOS) is a complex condition with mechanisms likely to involve the interaction between genetics and lifestyle. Familial clustering of PCOS symptoms is well documented, providing evidence for a genetic contribution to the condition. This overview aims firstly to systematically summarise the current literature surrounding genetics and PCOS, and secondly, to assess the methodological quality of current systematic reviews and identify limitations. Four databases were searched to identify candidate gene systematic reviews, and quality was assessed with the AMSTAR tool. Genome-wide association studies (GWAS) were identified by a semi structured literature search. Of the candidate gene systematic reviews, 17 were of high to moderate quality and four were of low quality. A total of 19 gene loci have been associated with risk of PCOS in GWAS, and 11 of these have been replicated across two different ancestries. Gene loci were located in the neuroendocrine, metabolic, and reproductive pathways. Overall, the gene loci with the most robust findings were THADA, FSHR, INS-VNTR, and DENND1A, that now require validation. This overview also identified limitations of the current literature and important methodological considerations for future genetic studies. Much work remains to identify causal variants and functional relevance of genes associated with PCOS.

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Association of SOD2 A16V and PON2 S311C polymorphisms with polycystic ovary syndrome in Chinese women

Liu

Bai

et al. 2019

J Endocrinol Invest

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Association of PON1 gene polymorphisms with polycystic ovarian syndrome risk: a meta-analysis of case–control studies

Cited by 7 publications

References 40 publications

Genetic construction between polycystic ovarian syndrome and type 2 diabetes

Genetic construction between polycystic ovarian syndrome and type 2 diabetes

The Genetics of Polycystic Ovary Syndrome: An Overview of Candidate Gene Systematic Reviews and Genome-Wide Association Studies

Association of SOD2 A16V and PON2 S311C polymorphisms with polycystic ovary syndrome in Chinese women

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