Objective: The aim of this study was to validate a novel pictorial-based Longshi Scale for evaluating a patient’s disability by healthcare professionals and non-professionals. Design: Prospective study. Setting: Rehabilitation departments from a grade A, class 3 public hospital, a grade B, class 2 public hospital, and a private hospital and seven community rehabilitation centers. Subjects: A total of 618 patients and 251 patients with functional disabilities were recruited in a two-phase study, respectively. Main measures: Outcome measure: pictorial scale of activities of daily living (ADLs, Longshi Scale). Reference measure: Barthel Index. The Spearman correlation coefficient was used to analyze the validity of Longshi Scale against Barthel Index. Results: In phase 1 study, from March 2016 to August 2016, the results demonstrated that the Longshi Scale was both reliable and valid (intraclass correlation coefficient based on two-way random effect (ICC2,1) = 0.877–0.974 for intra-rater reliability; ICC2,1 = 0.928–0.979; κ = 0.679–1.000 for inter-rater reliability; intraclass correlation coefficient based on one-way random effect (ICC1,1) = 0.921–0.984 for test–retest reliability and Spearman correlation coefficient = 0.836–0.899). In the second phase, in March 2018, results further demonstrated that the Longshi Scale had good inter-rater and intra-rater reliability among healthcare professionals and non-professionals including therapists, interns, and personal care aids (ICC1,1 = 0.822–0.882 on Day 1; ICC1,1 = 0.842–0.899 on Day 7 for inter-rater reliability). In addition, the Longshi Scale decreased assessment time significantly, compared with the Barthel Index assessment ( P < 0.01). Conclusion: The Longshi Scale could potentially provide an efficient way for healthcare professionals and non-professionals who may have minimal training to assess the ADLs of functionally disabled patients.

In the vertebrate visual system, ON cells respond to positive contrasts and OFF cells respond to negative contrasts, and thus both ON and OFF cells exhibit rectification. We investigated the retinal circuits by which the ON pathway rectifies the OFF pathway. White noise was projected onto an in vitro preparation of the mammalian retina and excitatory currents were recorded from retinal ganglion cells under whole-cell voltage clamp. Currents in OFF cells were more rectified than those in ON cells: thus, currents in ON cells were able to signal both positive and negative contrasts, but currents in OFF cells were virtually restricted to negative contrasts. Blocking signals in the ON pathway derectified currents in OFF ganglion cells, thus allowing them to be modulated by positive contrasts, indicating that the ON pathway normally rectifies currents in OFF ganglion cells. Such cross-rectification from ON to OFF pathways required intact glycinergic inhibition, indicating that a glycinergic amacrine cell, most likely the AII amacrine cell, allows the ON bipolar cell to hyperpolarize the OFF bipolar cell close to the threshold for transmitter release, thus rectifying excitatory currents in the OFF ganglion cell. Asymmetrical rectification of ON and OFF cells may be an adaptation to natural scenes that have more contrast levels below the mean than above. Thus, in order for ON and OFF pathways to encode an equal number of contrast levels, the ON cells must signal some negative contrasts.

Artificial intelligence in combination with design of experiments for sustainable process development achieving high quality metal–organic frameworks (MOFs) with minimal environmental effect.

In this paper, one-dimensional (1D) nonlinear Schrödinger equations iut − uxx + mu + ν|u| 4 u = 0, with Dirichlet boundary conditions are considered. It is proved that for all real parameters m, the above equation admits small-amplitude quasi-periodic solutions corresponding to b-dimensional invariant tori of an associated infinite-dimensional dynamical system. The proof is based on infinitedimensional KAM theory, partial normal form, and scaling skills.

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BackgroundThis study was performed to assess whether iterative reconstruction can reduce radiation dose while maintaining acceptable image quality, and to investigate whether perfusion parameters vary from conventional filtered back projection (FBP) at the low-tube-voltage (80-kVp) during whole-pancreas perfusion examination using a 256-slice CT.Methods76 patients with known or suspected pancreatic mass underwent whole-pancreas perfusion by a 256-slice CT. High- and low-tube-voltage CT images were acquired. 120-kVp image data (protocol A) and 80-kVp image data (protocol B) were reconstructed with conventional FBP, and 80-kVp image data were reconstructed with iDose4 (protocol C) iterative reconstruction. The image noise; contrast-to-noise ratio (CNR) relative to muscle for the pancreas, liver, and aorta; and radiation dose of each protocol were assessed quantitatively. Overall image quality was assessed qualitatively. Among 76 patients, 23 were eventually proven to have a normal pancreas. Perfusion parameters of normal pancreas in each protocol including blood volume, blood flow, and permeability-surface area product were measured.ResultsIn the quantitative study, protocol C reduced image noise by 36.8% compared to protocol B (P<0.001). Protocol C yielded significantly higher CNR relative to muscle for the aorta, pancreas and liver compared to protocol B (P<0.001), and offered no significant difference compared to protocol A. In the qualitative study, protocols C and A gained similar scores and protocol B gained the lowest score for overall image quality (P<0.001). Mean effective doses were 23.37 mSv for protocol A and 10.81 mSv for protocols B and C. There were no significant differences in the normal pancreas perfusion values among three different protocols.ConclusionLow-tube-voltage and iDose4 iterative reconstruction can dramatically decrease the radiation dose with acceptable image quality during whole-pancreas CT perfusion and have no significant impact on the perfusion parameters of normal pancreas compared to the conventional FBP reconstruction using a 256-slice CT scanner.

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Abstract. In this paper we prove an infinite dimensional KAM theorem, in which the assumptions on the derivatives of perturbation in [22] are weakened from polynomial decay to logarithmic decay. As a consequence, we apply it to 1d quantum harmonic oscillators and prove the reducibility of a linear harmonic oscillator,perturbed by a quasiperiodic in time potential V (x, ωt; ω) with logarithmic decay. This entails the pure-point nature of the spectrum of the Floquet operator K, whereand the potential V (x, θ; ω) has logarithmic decay as well as its gradient in ω.