Association between XRCC3 T241M polymorphism and glioma risk: a meta-analysis

Feng, Yuemin; Zeng, Miaoyu; Xu, Qin

doi:10.1007/s13277-014-1738-y

Cited by 7 publications

(5 citation statements)

References 15 publications

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“…Most of the results were consistent with our results showing that the XRCC3 Thr241Met polymorphism is a risk factor for glioma. However, Feng et al (2014), who analyzed 8 case-control studies including a total of 3455 glioma cases and 4435 controls, found no significant association between the XRCC3 T241M polymorphism and glioma (Feng et al, 2014). In subgroup analysis, this polymorphism appeared to be associated with an increased glioma risk in Asians in their analysis (Feng et al, 2014).…”

Section: Discussionmentioning

confidence: 94%

“…Previous studies found that the XRCC3 Thr241Met (rs861539) polymorphism may influence DNA repair capacity and also showed that the XRCC3 Thr241Met polymorphism may be associated with cancer risk (Matullo et al, 2006;Liu et al, 2007;López-Cima et al, 2007;Romanowicz-Makowska et al, 2012). Numerous studies have examined the relationship between the XRCC3 Thr241Met polymorphism and glioma risk, and meta-analysis studies showed positive results (Liang et al, 2013;Zhao et al, 2013;Wang et al, 2014) and also some negative results (Kiuru et al, 2008;Feng et al, 2014). The association strength between XRCC3 Thr241Met and glioma susceptibility remains unclear and requires further analysis.…”

Section: Discussionmentioning

confidence: 99%

“…However, Feng et al (2014), who analyzed 8 case-control studies including a total of 3455 glioma cases and 4435 controls, found no significant association between the XRCC3 T241M polymorphism and glioma (Feng et al, 2014). In subgroup analysis, this polymorphism appeared to be associated with an increased glioma risk in Asians in their analysis (Feng et al, 2014). Only 4 case-control studies have examined Asian glioma patients (Zhou et al, 2009;Liu et al, 2012;Luo et al, 2013;Pan et al, 2013), and more sample sizes are needed to confirm whether an association exists between the XRCC3 T241M polymorphism and glioma risk.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

DNA repair gene XRCC3 variants are associated with susceptibility to glioma in a Chinese population

Huang¹,

Yang²,

Qu³

et al. 2015

Genet. Mol. Res.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

DNA repair gene XRCC3 variants are associated with susceptibility to glioma in a Chinese population

Huang¹,

Yang²,

Qu³

et al. 2015

Genet. Mol. Res.

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“…It has been reported that XRCC3 Thr241Met polymorphism, located on exon 7, affected the enzyme function and/or its interaction with other proteins involved in DNA damage and repair. More importantly, many studies indicated that XRCC3 T241M polymorphism might be associated with increased risks of a number of human cancers, such as glioma, bladder, and breast cancer [ 8 ]. For breast cancer, although a number of studies suggested that it might be related to increased risks of carcinogenesis, the results remain controversial.…”

Section: Introductionmentioning

confidence: 99%

Association between XRCC3 Thr241Met Polymorphism and Risk of Breast Cancer: Meta-Analysis of 23 Case-Control Studies

et al. 2015

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BackgroundStudies have shown that gene and environmental factors, such as BRCA1/2 mutations, ionized radiation, and chemical carcinogens, are related with breast cancer. X-ray repair cross-complementing group 3 (XRCC3) is involved in homologous repair of double DNA breaks. It was reported that Thr241Met single-nucleotide polymorphism (SNP) in XRCC3 is associated with increased risk of breast cancer. However, the finding remains controversial. The current meta-analysis aims to determine whether XRCC3 Thr241Met polymorphism is associated with increased risk of breast cancer.Material/MethodsWe performed a meta-analysis of association between XRCC3 T241M polymorphism and the risk of breast cancer. Crude odds ratios (ORs) together with 95% confidence intervals (CIs) were used to assess the strength of association in dominant, recessive, and homozygote models.ResultsWe included 23 studies consisting of 13513 cases and 14100 controls in our study. For meta-analysis on the entire database, association of the SNP and breast cancer risk was observed in recessive (OR=1.10, 95% CI: 1.03–1.18, p=0.005) and homozygote (OR=1.09, 95% CI: 1.01–1.18, p=0.023) models. For the analysis on the Asian population subgroup, association of the SNP and breast cancer risk was also observed in recessive (OR=1.615, 95% CI: 1.17–2.228, p=0.004) and homozygote (OR=1.609, 95% CI: 1.154-2.241, p=0.005) models. For the evaluation of the patients without family history of breast cancer, association of the SNP and breast cancer risk was observed in dominant (OR=1.364, 95% CI: 1.096–1.698, p=0.005), recessive (OR=1.336, 95% CI: 0.999–1.788, p=0.051) and homozygote (OR=1.492, 95% CI: 1.085–2.051, p=0.014) models.ConclusionsWe can conclude that XRCC3 Thr241Met polymorphism might be associated with breast cancer risk, especially in Asian populations and in patients without family history of breast cancer.

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“…A well-conducted metaanalysis is essential to address these inconsistencies. However, the most recent meta-analyses on this topic were conducted many years ago [72][73][74][75][76][77] and did not include several eligible studies. The lack of meticulous data extraction in meta-analysis can lead to misleading results [78].…”

Section: Plos Onementioning

confidence: 99%

Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: A systematic review and meta-analysis

Tan

Low²,

Hussain³

et al. 2022

PLoS ONE

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Background The XRCC3 p.Thr241Met (rs861539) polymorphism has been extensively studied for its association with glioma risk, but results remain conflicting. Therefore, we performed a systematic review and meta-analysis to resolve this inconsistency. Methods Studies published up to June 10, 2022, were searched in PubMed, Web of Science, Scopus, VIP, Wanfang, and China National Knowledge Infrastructure databases and screened for eligibility. Then, the combined odds ratio (OR) of the included studies was estimated based on five genetic models, i.e., homozygous (Met/Met vs. Thr/Thr), heterozygous (Thr/Met vs. Thr/Thr), dominant (Thr/Met + Met/Met vs. Thr/Thr), recessive (Met/Met vs. Thr/Thr + Thr/Met) and allele (Met vs. Thr). The study protocol was preregistered at PROSPERO (registration number: CRD42021235704). Results Overall, our meta-analysis of 14 eligible studies involving 12,905 subjects showed that the p.Thr241Met polymorphism was significantly associated with increased glioma risk in both homozygous and recessive models (homozygous, OR = 1.381, 95% CI = 1.081–1.764, P = 0.010; recessive, OR = 1.305, 95% CI = 1.140–1.493, P<0.001). Subgroup analyses by ethnicity also revealed a statistically significant association under the two aforementioned genetic models, but only in the Asian population and not in Caucasians (P>0.05). Conclusion We demonstrated that the XRCC3 p.Thr241Met polymorphism is associated with an increased risk of glioma only in the homozygous and recessive models.

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Association between XRCC3 T241M polymorphism and glioma risk: a meta-analysis

Cited by 7 publications

References 15 publications

DNA repair gene XRCC3 variants are associated with susceptibility to glioma in a Chinese population

DNA repair gene XRCC3 variants are associated with susceptibility to glioma in a Chinese population

Association between XRCC3 Thr241Met Polymorphism and Risk of Breast Cancer: Meta-Analysis of 23 Case-Control Studies

Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: A systematic review and meta-analysis

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