Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: A systematic review and meta-analysis

Abstract

Background The XRCC3 p.Thr241Met (rs861539) polymorphism has been extensively studied for its association with glioma risk, but results remain conflicting. Therefore, we performed a systematic review and meta-analysis to resolve this inconsistency. Methods Studies published up to June 10, 2022, were searched in PubMed, Web of Science, Scopus, VIP, Wanfang, and China National Knowledge Infrastructure databases and screened for eligibility. Then, the combined odds ratio (OR) of the included studies was estimated based on five genetic models, i.e., homozygous (Met/Met vs. Thr/Thr), heterozygous (Thr/Met vs. Thr/Thr), dominant (Thr/Met + Met/Met vs. Thr/Thr), recessive (Met/Met vs. Thr/Thr + Thr/Met) and allele (Met vs. Thr). The study protocol was preregistered at PROSPERO (registration number: CRD42021235704). Results Overall, our meta-analysis of 14 eligible studies involving 12,905 subjects showed that the p.Thr241Met polymorphism was significantly associated with increased glioma risk in both homozygous and recessive models (homozygous, OR = 1.381, 95% CI = 1.081–1.764, P = 0.010; recessive, OR = 1.305, 95% CI = 1.140–1.493, P<0.001). Subgroup analyses by ethnicity also revealed a statistically significant association under the two aforementioned genetic models, but only in the Asian population and not in Caucasians (P>0.05). Conclusion We demonstrated that the XRCC3 p.Thr241Met polymorphism is associated with an increased risk of glioma only in the homozygous and recessive models.

Association between IL10 rs1800896 polymorphism and risk of pediatric asthma: A meta‐analysis

“…The different observations between different subgroups are not surprising. Many genetic association studies have found significant associations in one ethnic group but not in the others 24–29 . This differential association underscores the interaction between genetic and nongenetic factors in the development of a disease 30 .…”

“…Many genetic association studies have found significant associations in one ethnic group but not in the others. 24 , 25 , 26 , 27 , 28 , 29 This differential association underscores the interaction between genetic and nongenetic factors in the development of a disease. 30 Indeed, longitudinal studies have shown that ethnic‐related differences are present in asthma risk and its outcomes.…”

Novel cis compound heterozygous variants in MYO6 causes early onset of non-syndromic hearing loss in a Chinese family

“…Besides this, single nucleotide polymorphisms (SNPs) were alos associated with the hearing loss and other diseases ( Antonino et al, 2022 ; Li et al, 2022 ; Tan et al, 2022 ). Meta analysis and screening studies for such genetic markes have shown a strong association of SNPs with hearing loss suggesting their important role in normal functioning and development.…”