DNA repair gene XRCC3 variants are associated with susceptibility to glioma in a Chinese population

Huang, Juan; Yang, Jing; Qu, Qiang; Qu, Jian; Liu, F; Liu, F E; Xiong, Tingting; Lu, Shijuan

doi:10.4238/2015.september.8.18

Cited by 6 publications

(10 citation statements)

References 26 publications

(31 reference statements)

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“…The genotype distributions in all groups were in Hardy-Weinbergequilibrium. Allele frequencies were also in agreement with previous publication [22]. As can be seen in Table 5 and Fig.…”

Section: Distribution Of T241m Xrcc3 Polymorphism and Itsassociation supporting

confidence: 81%

Micronucleus Frequencies and DNA Repair Gene XRCC3 Polymorphism in Radiation Workers of Center for Multipurpose Reactor

et al. 2018

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The carcinogenic effects of low radiation doses have not been fully understood until now. Studies on individuals that are occupationally exposed to low radiation doses can help to address this question. This study assesses the micronucleus (MN) frequencies as indicator of DNA damage in radiation workers that are occupationally exposed to low radiation dose. The influence of single nucleotide polymorphisms (SNPs) in XRCC3 gene on the frequency of micronuclei was also evaluated in this study. The effects of confounding factors of gender, age, and smoking status on MN frequencies was assessed in all samples. A total of 60 subjects consisting of 30 radiation workers from Center of Multipurpose Reactor (CMPR), National Nuclear Energy Agency (NNEA) of Indonesia, and 30 control samples were enrolled in this study. The results showed that the difference between MN frequency in radiation workers and in control samples was not statistically significant [0.019 vs. 0.021; p = 0.549]. Age and smoking status did not affect micronucleus frequencies in all samples (p = 0.723 and 0.828). Micronucleus frequencies in females were higher compared to males, even though the difference was not significant (p = 0.3). Radiation workers with variant alleles for XRCC3 polymorphism did not showed higher MN frequencies compared to the controls with the same genotypes. The small numbers of samples with XRCC3 variant alleles found in this study possibly contributed to the insignificant difference of MN frequencies between wild-type allele (Thr/Thr) and mutant alleles (Thr/Met or Met/Met). Further investigations using larger sample sizes and MN assay in combination with human pan-centromeric probe should be conducted to validate this study results. Other SNP in XRCC3 gene also should be evaluated to find out the association between SNP and MN frequencies.

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“…The genotype distributions in all groups were in Hardy-Weinbergequilibrium. Allele frequencies were also in agreement with previous publication [22]. As can be seen in Table 5 and Fig.…”

Section: Distribution Of T241m Xrcc3 Polymorphism and Itsassociation supporting

confidence: 81%

Micronucleus Frequencies and DNA Repair Gene XRCC3 Polymorphism in Radiation Workers of Center for Multipurpose Reactor

et al. 2018

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“…Instead, Liu et al 2009 [ 36 ] combined the homozygous wild type (Thr/Thr) and heterozygous genotypes (Thr/Met). Moreover, of all 14 studies, the distribution of control genotypes did not deviate significantly from HWE in only five studies (P>0.05) [ 21 , 33 , 37 , 39 , 41 ]. Nevertheless, all 14 studies were of high quality ( S1 Table ).…”

Section: Resultsmentioning

confidence: 99%

Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: A systematic review and meta-analysis

Tan

Low²,

Hussain³

et al. 2022

PLoS ONE

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Background The XRCC3 p.Thr241Met (rs861539) polymorphism has been extensively studied for its association with glioma risk, but results remain conflicting. Therefore, we performed a systematic review and meta-analysis to resolve this inconsistency. Methods Studies published up to June 10, 2022, were searched in PubMed, Web of Science, Scopus, VIP, Wanfang, and China National Knowledge Infrastructure databases and screened for eligibility. Then, the combined odds ratio (OR) of the included studies was estimated based on five genetic models, i.e., homozygous (Met/Met vs. Thr/Thr), heterozygous (Thr/Met vs. Thr/Thr), dominant (Thr/Met + Met/Met vs. Thr/Thr), recessive (Met/Met vs. Thr/Thr + Thr/Met) and allele (Met vs. Thr). The study protocol was preregistered at PROSPERO (registration number: CRD42021235704). Results Overall, our meta-analysis of 14 eligible studies involving 12,905 subjects showed that the p.Thr241Met polymorphism was significantly associated with increased glioma risk in both homozygous and recessive models (homozygous, OR = 1.381, 95% CI = 1.081–1.764, P = 0.010; recessive, OR = 1.305, 95% CI = 1.140–1.493, P<0.001). Subgroup analyses by ethnicity also revealed a statistically significant association under the two aforementioned genetic models, but only in the Asian population and not in Caucasians (P>0.05). Conclusion We demonstrated that the XRCC3 p.Thr241Met polymorphism is associated with an increased risk of glioma only in the homozygous and recessive models.

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“…Moreover, the rate of constant activation of cell division increases, and the odds for occurrence of DNA replicative errors favour the appearance of mutations involved in initiation and development of liver cancer. Mainstream publications include numerous studies proving that rs861539 polymorphism of the XRCC3 gene influences susceptibility of developing several types of cancer, namely: oesophageal [28,29], gastric [30,31], breast [32,33,34,35], colorectal [36,37,38], urinary bladder [39], ovarian [40], thyroid [41], prostate [42], liver [3,43,44,45,46,47,48,49,50], and glioma [20,51]. On the other hand, there is little information about the functional consequences of the presence of polymorphism rs1799796 because it is scarcely investigated.…”

Section: Discussionmentioning

confidence: 99%

“…It consists of the substitution of adenine with guanine, and it is located in an uncoding segment [19]. For this SNP there are three genotype variants: wild type (AA), heterozygote (AG), and homozygote (GG) [20].…”

Section: Introductionmentioning

confidence: 99%

Single nucleotide polymorphisms of XRCC3 gene in hepatocellular carcinoma – relationship with clinicopathological features

Avădănei¹,

Giuşcă²,

Negura³

et al. 2018

pjp

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Recent studies support the involvement of XRCC3 gene polymorphisms in carcinogenesis. Our study focuses on the identification of polymorphic variants of XRCC3 in hepatocellular carcinoma (HCC) and an analysis of the relationship between these polymorphic variants and clinicopathological (including the genotype specific risk) and survival characteristics. Fifty cases of HCC were genotyped using molecular biology techniques for Thr241Met, rs861539 (c.722C>T) and 5'-UTR, rs1799796 (c.562-14A>G) polymorphisms. Statistical analysis was based on χ2, Fisher's, logistic regression (odd ratio -OR), and log-rank tests. Statistically significant differences were shown only for rs1799796 A>G and tumour grade, between wild type (AA) and heterozygote (AG) genotypes, and wild type (AA) and heterozygote & homozygote (AG & GG) genotypes. The logistic regression analysis found an OR of rs1799796 polymorphism occurrence in HCC related to tumour grade. The statistical analysis revealed, for the rs861539 C>T polymorphism, a better survival only for the homozygote genotype (TT) compared to the heterozygote (CT), and for rs1799796 A>G polymorphism, a longer survival for the wild type (AA) compared to heterozygote (AG) and to heterozygote & homozygote (AG & GG) genotypes, respectively. Our results suggest that XRCC3 gene SNPs could influence the tumour aggressiveness expressed by tumour grade.

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DNA repair gene XRCC3 variants are associated with susceptibility to glioma in a Chinese population

Cited by 6 publications

References 26 publications

Micronucleus Frequencies and DNA Repair Gene XRCC3 Polymorphism in Radiation Workers of Center for Multipurpose Reactor

Micronucleus Frequencies and DNA Repair Gene XRCC3 Polymorphism in Radiation Workers of Center for Multipurpose Reactor

Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: A systematic review and meta-analysis

Single nucleotide polymorphisms of XRCC3 gene in hepatocellular carcinoma – relationship with clinicopathological features

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