Association between Vitamin D receptor (Cdx2, Fok1, Bsm1, Apa1, Bgl1, Taq1, and Poly (A)) gene polymorphism and breast cancer: A systematic review and meta-analysis

Abstract

The purpose of this systemic review and meta-analysis was to examine the relationship between VDR gene polymorphisms and breast cancer. Literature was searched through PubMed database, Google scholar, and the web of knowledge from December 2015 to January 2017 and consists of 34 studies (26,372 cases and 32,883 controls). All statistical measures were done using STATA version 11.2. The heterogeneity among studies was tested using I statistics. Mantel-Haenszel method and DerSimonian-Laird method were used to combine data from studies using both random-effect model and fixed-effect model, respectively. Potential publication bias was evaluated by Egger's test. Sensitivity analysis was also performed to evaluate the quality and consistency in results. The results of this meta-analysis revealed that VDR gene polymorphisms (Bsm1 bb vs BB; SOR = 1.18, 95% CI = 1.054-1.322, Apa1 aa vs AA; SOR = 1.18, 95% CI = 0.87-1.59, Poly (A) LL vs SS; SOR = 1.41, 95% CI = 1.06-1.88, Fok1 ff + Ff vs FF; SOR = 1.25, 95% CI = 0.896-1.759, Apa1 aa+Aa vs AA; SOR = 1.13, 95% CI = 0.95-1.35, Poly (A) LL + LS vs SS; SOR = 1.19, 95% CI = 1.00-1.43, Poly (A) L vs S; SOR = 1.18, 95% CI = 1.03-1.35) are associated with the breast cancer. Cdx2, Bgl1, and Taq1 do not show association with breast cancer. Thus, the finding of this meta-analysis concluded that VDR Bsm1, Apa1, Fok1, and Poly (A) gene polymorphisms may be susceptible for breast cancer development.

Impact of Vitamin D Receptor Gene Polymorphism on Chronic Renal Failure Susceptibility

“…The FokI site is located in a coding exon at the start of the gene and could alter the structure of the VDR gene . It has been demonstrated that VDR gene polymorphisms are associated with several diseases such as hepatitis, multiple sclerosis and breast cancer . The relationship between CRF and VDR gene polymorphisms has been studied.…”

Vitamin D levels in Mediterranean breast cancer patients compared with those in healthy women

“…Preclinical studies suggest a protective effect of vitamin D on cancer risk and progression [6,7], but clinical and epidemiologic studies have reported controversial results [8][9][10][11][12]. However, the available evidences that vitamin D levels may affect breast cancer survival [13,14] are sufficient to suggest that vitamin D status should be monitored.…”

Association of Vitamin D Receptor Gene Polymorphism With the Risk of Nephrolithiasis

“…There has been a growing literature on the effects of vitamin D/VDR outside of its traditional role in calcium and phosphorus homeostasis. It has been demonstrated that VDR gene polymorphisms are associated with various diseases such as breast cancer , chronic kidney disease , diabetes mellitus , renal cancer , immunodeficiency , Behcet's disease , psychosis , and lupus . Unfortunately the results have often been conflicting; for this reason, a clearer understanding of the nontraditional role of vitamin D/VDRs is becoming ever more important for those of us who work in renal medicine.…”