Association of Vitamin D Receptor Gene Polymorphism With the Risk of Nephrolithiasis

Yang, Shikun; Song, Na; Wang, Yangyang; Li, Ai‐Mei; Liu, Jun; Deng, Fei; Zhan, Ming; Zhang, Wei; Han, Yachun; Zhang, Hao

doi:10.1111/1744-9987.12797

Cited by 5 publications

(2 citation statements)

References 51 publications

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“…There are four main genetic variations in the VDR gene, including rs2228570 (FokI), rs731236 (TaqI), rs7975232 (ApaI), and rs1544410 (BsmI) ( Mossetti et al, 2003 ; Seo et al, 2010 ; Yang et al, 2019a ; Amar et al, 2020a ). From 1998 to 2021, seventy-two articles investigating the role of different SNPs in the VDR gene were included in the meta-analysis ( Ruggiero et al, 1998 ; JACKMAN et al, 1999 ; Chen et al, 2001 ; Nishijima et al, 2002 ; Mossetti et al, 2003 ; Shaogang et al, 2003 ; Özkaya et al, 2003 ; Mossetti et al, 2004 ; Relan et al, 2004 ; Rendina et al, 2004 ; Gunes et al, 2006 ; Franco et al, 2007 ; Liu et al, 2007 ; Moyano et al, 2007 ; Seyhan et al, 2007 ; Mittal et al, 2010 ; Seo et al, 2010 ; Aji et al, 2012 ; Basiri et al, 2012 ; Wang et al, 2012 ; Aykan et al, 2014 ; Guha et al, 2015 ; Aykan et al, 2016 ; Cakir et al, 2016 ; Goknar et al, 2016 ; Aghamir et al, 2017 ; Rendina et al, 2017 ; Subasi et al, 2017 ; Wang et al, 2017 ; Ergon et al, 2018 ; Amar et al, 2019 ; Yang et al, 2019a ; Yang et al, 2019b ; Huang et al, 2019 ; Li et al, 2019 ; Jawad and Awad, 2020 ). The overall estimate of OR for each SNP in forest plots.…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms and Kidney Stones Around the Globe: A Systematic Review and Meta-Analysis

et al. 2022

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Objective: This study explores associations between recurrent kidney stones and genetic polymorphisms.Methods: Meta-analysis of polymorphisms in renal stone cases versus control groups. Four electronic databases (PubMed, SCOPUS, EMBASE, and Web of Science) were searched up to 30 May 2021, using the keywords: “kidney stone” or “kidney calculi,” or “urolithiasis” or “nephrolithiasis” or “urinary calculi” and “genome” or “genetic” or “mutation” or “single nucleotide polymorphism.” Forrest plots, ORs, 95% CI, Chi-square (χ2)-test, and index of heterogeneity (I2) were calculated. Only studies with Newcastle–Ottawa scale (NOS) ≥ 6 were included for quality control, and Funnel, Begg’s, and Eager’s plots assessed publication bias. PROSPERO: CRD42022250427.Results: Among 7,671 searched articles, 72 were included. Polymorphisms in VDR (OR: 1.20; 95% CI: 1.06–1.36), CASR (OR = 1.24; 95% CI: 1.01–1.52), Osteopontin (OR = 1.38; 95% CI: 1.09–1.74), and Urokinase genes (OR = 1.52; 95% CI: 1.02–2.28) showed a significant association with risk of urinary stone formation, while Klotho gene showed a protective effect (OR = 0.75; 95% CI: 0.57–0.99). The VDR gene polymorphism was frequent in Asians, whereas CASR polymorphism was frequent in European and North American populations.Conclusion: Multifactorial nature of the stone formation, emphasizing the role of environmental factors, might explain contradictory results in the literature. While polymorphisms in VDR, CASR, Osteopontin, and Urokinase genes were associated with urinary stone formation, the Klotho gene showed a protective effect.

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Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms and Kidney Stones Around the Globe: A Systematic Review and Meta-Analysis

et al. 2022

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“…Given the crucial role of vitamin D in calcium homeostasis, the genetic alterations in the VDR gene could affect vitamin D action both during intestinal absorption and renal calcium handling, leading to hypercalciuria and stone formation. There is epidemiological evidence of allelic variation in the VDR gene that might be involved in calcium stone etiology in definite human populations 9‐13 …”

Section: Introductionmentioning

confidence: 99%

The association between single nucleotide polymorphism in vitamin D receptor and calcium oxalate urolithiasis in dogs

Chamsuwan

Angkanaporn

Dissayabutra

et al. 2021

Veterinary Internal Medicne

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Background Polymorphisms of the vitamin D receptor (VDR) are associated with calcium oxalate (CaOx) nephrolithiasis in humans. Objectives To investigate the association between VDR polymorphisms and susceptibility to CaOx urolithiasis in dogs. Animals Thirty‐five dogs with CaOx urolithiasis were compared with 40 stone‐free dogs. Methods This was a case‐control study. Two VDR gene polymorphisms (rs851998024 and rs852900542) were detected by specific TaqMan real‐time polymerase chain reaction assay, and their relationship with serum 1,25‐dihydroxyvitamin D, serum and urinary electrolyte concentrations was evaluated. Results The distribution of the rs852900542 polymorphism was significantly different between the case and the control dogs (x2 = 6.369, P = .04). Dogs with a CC or CT genotype had an increased risk of CaOx stones than those with the TT genotype (odds ratio = 3.82, 95% confidence interval 1.04‐13.98). The CaOx dogs with the TT genotype had a significantly lower urinary calcium‐to‐creatinine ratio than the CT+CC genotypes. 1,25‐(OH)2D concentrations did not differ between the cases and the controls (308.7 ± 217.4 vs 286.7 ± 185.1 pg/mL, P = .45). Conclusions and Clinical Importance This finding suggests that vitamin D metabolism might play a role in CaOx stone formation in dogs.

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Association of single nucleotide genetic polymorphisms of vitamin D receptor and calcium-sensitive receptor with calcium-containing kidney stones in Chinese Dai populations: a prospective multi-center study

Li,

Ke,

Zhang

et al. 2024

Int Urol Nephrol

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Association of Vitamin D Receptor Gene Polymorphism With the Risk of Nephrolithiasis

Cited by 5 publications

References 51 publications

Genetic Polymorphisms and Kidney Stones Around the Globe: A Systematic Review and Meta-Analysis

Genetic Polymorphisms and Kidney Stones Around the Globe: A Systematic Review and Meta-Analysis

The association between single nucleotide polymorphism in vitamin D receptor and calcium oxalate urolithiasis in dogs

Association of single nucleotide genetic polymorphisms of vitamin D receptor and calcium-sensitive receptor with calcium-containing kidney stones in Chinese Dai populations: a prospective multi-center study

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