Association between urinary thallium exposure and cardiovascular disease in U.S. adult population

Wang, Sibo; Sun, Junran; Tang, Chunping; Gu, Lingfeng; Du, Chong; Wang, Hao; Ma, Yao; Wang, Liansheng

doi:10.1016/j.chemosphere.2022.133669

Cited by 16 publications

(5 citation statements)

References 47 publications

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“…Increasing evidence has shown that long-term exposure to low concentrations of heavy metals may lead to a variety of medical conditions. One study demonstrated that urinary thallium intake is associated with cardiovascular disease [ 18 ]. Multiple heavy metals in the human body have been studied and found to be associated with dyslipidemia and hypertension [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Association between urinary cobalt exposure and kidney stones in U.S. adult population: results from the National Health and Nutrition Examination Survey

Lu,

Hong,

et al. 2024

Renal Failure

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Purpose Heavy metal exposure can cause impaired or reduced pathology in the kidneys, lungs, liver, and other vital organs. However, the relationship between heavy metal exposure and kidney stones has not been determined. The goal of this research was to determine the association between heavy metal exposure and kidney stones in a population of American adults in general. Materials and methods We evaluated 29,201 individuals (≥20 years) from the National Health and Nutrition Examination Survey (NHANES). The association between heavy metal exposure and kidney stones was verified by multiple logistic regression and restricted cubic spline (RCS) regression. Dose–response curves were generated to analyze the relationship between heavy metal concentrations and the occurrence of kidney stones. Moreover, we used propensity score matching (PSM) to exclude the effect of confounding variables. Results After a rigorous enrollment screening process, we included 8518 participants. Logistic regression showed that urinary cadmium (U-Cd) and urinary cobalt (U-Co) concentrations were significantly different in the kidney stone group before PSM ( p < 0.001). Dose–response curves revealed that the occurrence of kidney stones increased significantly with increasing U-Cd and U-Co concentrations. After adjustment for covariates, only biomarkers of U-Co were linked to the occurrence of kidney stones. When the lowest quartile was used as a reference, the 95% confidence intervals (95% CIs) for kidney stones across the other quartiles were 1.015 (0.767–1.344), 1.409 (1.059–1.875), and 2.013 (1.505–2.693) for U-Cos ( p < 0.001). Conclusion In the U.S. population, high U-Co levels are positively correlated with the potential risk of kidney stones.

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Section: Discussionmentioning

confidence: 99%

Association between urinary cobalt exposure and kidney stones in U.S. adult population: results from the National Health and Nutrition Examination Survey

Lu,

Hong,

et al. 2024

Renal Failure

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“…28 Chronic low-dose or acute high-dose exposure to Tl could cause gastrointestinal, neurological, and dermatological symptoms or even death. 29,30 However, the results from colorectal toxicity and tumorigenesis studies on Tl remain to be fully elucidated and understood.…”

Section: Discussionmentioning

confidence: 99%

“…Continuous low-dose exposure to Tl in the nonoccupational population may result from drinking water, air pollution, and food contaminated with Tl . Chronic low-dose or acute high-dose exposure to Tl could cause gastrointestinal, neurological, and dermatological symptoms or even death. , However, the results from colorectal toxicity and tumorigenesis studies on Tl remain to be fully elucidated and understood.…”

Section: Discussionmentioning

confidence: 99%

Metal Exposure Promotes Colorectal Tumorigenesis via the Aberrant N⁶-Methyladenosine Modification of ATP13A3

Chen

et al. 2023

Environ. Sci. Technol.

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Element contamination, including that from heavy metals, is associated with gastrointestinal tumorigenesis, but the effects and mechanisms of crucial element exposure associated with colorectal cancer remain unclear. We profiled 56 elements by ICP-MS and used logistic regression, LASSO, BKMR, and GAM to identify colorectal cancer-relevant elements. A series of biochemical experiments were performed to demonstrate the cytotoxicity and the mechanisms of malignant transformation after metal exposure. Using an elementomics approach, we first found that the metal thallium (Tl) was positively correlated with many toxic metals and was associated with a significantly increased risk of colorectal cancer. Acute exposure to Tl induced cytotoxicity and cell death by accelerating the generation of reactive oxygen species and DNA damage. Chronic exposure to Tl led to the inhibition of cell death and thereby induced the malignant transformation of normal colon cells and xenograft tumor formation in nude mice. Furthermore, we describe the first identification of a significant metal quantitative trait locus for the novel colorectal cancer susceptibility locus rs1511625 near ATP13A3. Mechanistically, Tl increased the level of aberrant N 6 -methyladenosine (m 6 A) modification of ATP13A3 via the METLL3/ METTL14/ALKBH5-ATP13A3 axis to promote colorectal tumorigenesis. This study provides a basis for the development of public health strategies for reducing metal exposure among populations at high risk for colorectal cancer.

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“…Information about covariates was also collected through the questionnaires and health examination in the mobile centers, including age, race, education levels, annual family income, body mass index (BMI), physical activity, serum cotinine, marital status, calcium intake, smoking status, drinking status, and use of prednisone or cortisone. Study participants who had at least 12 alcoholic drinks/year were considered as drinkers, and those who smoked at least 100 cigarettes in life were considered as smokers following previous studies ( 21 , 22 ). The calcium intake was classified into three groups based on tertiles of estimated calcium intake during the 24 hours before the interview (low, <621 mg/day; middle, 621–1026 mg/day; high, >1026 mg/day).…”

Section: Methodsmentioning

confidence: 99%

Systemic immune-inflammation index is associated with decreased bone mass density and osteoporosis in postmenopausal women but not in premenopausal women

Zhang

Jiang

Qin

et al. 2023

Endocrine Connections

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Purpose: This study aims to investigate the associations of the systemic immune-inflammation index (SII) with bone mineral density (BMD) and osteoporosis in adult females from a nationally representative sample. Methods: A cross-sectional study was performed among 4,092 females aged ≥20 years from the National Health and Nutrition Examination Survey (NHANES) 2007–2010. Linear and logistic regressions were applied to explore the relationships of SII with BMD and the risk of osteoporosis, respectively. Results: Linear regression analyses found that a doubling of SII levels was significantly correlated with a 1.39% [95% % confidence interval (CI): 0.57%, 2.20%] decrease in total femur BMD, a 1.16% (95% CI: 0.31%, 2.00%) decrease in femur neck BMD, a 1.73% (95% CI: 0.78%, 2.66%) decrease in trochanter BMD and a 1.35% (95% CI: 0.50%, 2.20%) decrease in intertrochanteric BMD among postmenopausal women, after adjusting for covariates. Logistic regression analyses showed that compared with postmenopausal women in the lowest SII quartile, those in the highest quartile had higher risks of osteoporosis in the total femur [odds ratio (OR) =1.70, 95% CI: 1.04, 2.76], trochanter (OR=1.86, 95% CI: 1.07, 3.38), intertrochanter (OR=2.01, 95% CI: 1.05, 4.04) as well as overall osteoporosis (OR=1.57, 95% CI: 1.04, 2.37). In contrast, there was no significant association between SII and BMD in premenopausal women. Conclusions: SII levels were negatively associated with BMD levels in postmenopausal women but not in premenopausal women. Elevated SII levels could be a potential risk factor for osteoporosis in postmenopausal women.

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Association between urinary thallium exposure and cardiovascular disease in U.S. adult population

Cited by 16 publications

References 47 publications

Association between urinary cobalt exposure and kidney stones in U.S. adult population: results from the National Health and Nutrition Examination Survey

Association between urinary cobalt exposure and kidney stones in U.S. adult population: results from the National Health and Nutrition Examination Survey

Metal Exposure Promotes Colorectal Tumorigenesis via the Aberrant N⁶-Methyladenosine Modification of ATP13A3

Systemic immune-inflammation index is associated with decreased bone mass density and osteoporosis in postmenopausal women but not in premenopausal women

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Association between urinary thallium exposure and cardiovascular disease in U.S. adult population

Cited by 16 publications

References 47 publications

Association between urinary cobalt exposure and kidney stones in U.S. adult population: results from the National Health and Nutrition Examination Survey

Association between urinary cobalt exposure and kidney stones in U.S. adult population: results from the National Health and Nutrition Examination Survey

Metal Exposure Promotes Colorectal Tumorigenesis via the Aberrant N6-Methyladenosine Modification of ATP13A3

Systemic immune-inflammation index is associated with decreased bone mass density and osteoporosis in postmenopausal women but not in premenopausal women

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Metal Exposure Promotes Colorectal Tumorigenesis via the Aberrant N⁶-Methyladenosine Modification of ATP13A3