Association between transcription factor 7-like 2 rs7903146 polymorphism and diabetic retinopathy in type 2 diabetes mellitus: A meta-analysis

Ding, Yibing; Hu, Zizhong; Yuan, Songtao; Xie, Ping

doi:10.1177/1479164115598274

Cited by 10 publications

(5 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[4–9] One of the most important factors is the transcription factor 7-like 2 (TCF7L2), which involves in insulin secretion. [10–13] Previous studies have also confirmed that TCF7L2 association is highly reproducible in various ethnic populations with T2DM. [10–21]…”

Section: Introductionmentioning

confidence: 85%

Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with type 2 diabetes mellitus in Chinese Korean ethnicity population

Zhou¹,

Liu²,

Wang³

et al. 2019

Medicine

View full text Add to dashboard Cite

Presently, data on the type 2 diabetes mellitus (T2DM) in Chinese Korean ethnicity are very scarce. This study aimed to explore the relationship between the transcription factor 7-like 2 (TCF7L2) and T2DM in Chinese Korean ethnicity population. This case-control study involved 43 T2DM Chinese Korean ethnicity patients (T2DM group) and 43 healthy Chinese Korean ethnicity normoglycemic subjects as controls (Control group). All included participants aged from 40 to 75 years old. Clinical and biological data were collected to determine the phenotypic traits. The restriction fragment length polymorphism-polymerase chain reaction was used to analyze the TCF7L2 by genotyping for rs7903146 (C/T). Spectrophotometer with Chronolab kits was used to conduct the biochemical analyses. TCF7L2 was associated with T2DM in the Chinese Korean ethnicity population ( P < .01 for alleles, and P < .05 for genotypes). Significant differences were found 2 groups regarding the T allele (37.2% T2DM patients vs 15.1% healthy subjects, P < .01), and G allele (62.8% T2DM patients vs 84.9% healthy subjects, P < .01). The risk genotypes were GG (83.7% T2DM patients, vs 44.2% healthy control, P < .01), GT (4.7% T2DM patients, vs 20.9% healthy control, P = .04), and TT (11.6% T2DM patients, vs 34.9% healthy control, P = .01). The results of this study demonstrated that TCF7L2 is associated with T2DM in the Chinese Korean ethnicity population, which is an important risk factor for T2DM in this population.

show abstract

Section: Introductionmentioning

confidence: 85%

Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with type 2 diabetes mellitus in Chinese Korean ethnicity population

Zhou¹,

Liu²,

Wang³

et al. 2019

Medicine

View full text Add to dashboard Cite

show abstract

“…Previous studies have identified genetic variants significantly associated with DR in various ethnic groups 17 – 21 . Here, we confirmed the association of PLXDC2, ARHGAP22, CNTN5 , and FMN1 polymorphisms with DR in the Taiwanese population.…”

Section: Discussionmentioning

confidence: 99%

“…All of the genetic markers were selected based on previous reports. The inclusion criteria of candidate SNPs were set as a combined P < 10 −4 for GWAS 18 , 19 , 23 , 29 and a P < 0.05 for meta-analysis 20 , 21 , 30 – 50 . A total of 58 SNPs in 44 susceptibility loci were evaluated in our study (details are summarized in Table S1 ).…”

Section: Methodsmentioning

confidence: 99%

Multilocus genetic risk score for diabetic retinopathy in the Han Chinese population of Taiwan

Liao

Lin

Chen

et al. 2018

Sci Rep

View full text Add to dashboard Cite

The aim of this study is to explore the effect of genetic variation on diabetic retinopathy (DR) risk in a Taiwanese population. The logistic regression model was used to evaluate the relationship between DR status and risk factors, including the conventional parameters and genetic risk score (GRS). Candidate single nucleotide polymorphisms (SNPs) in GRS were selected based on previous reports with a combined P < 10−4 (genome-wide association) and P < 0.05 (meta-analysis). In total, 58 SNPs in 44 susceptibility loci were selected, and four were used to calculate GRS. After adjustment for age, systolic blood pressure, diabetes duration, and HbA1c, the DR risk was 4.95 times higher for patients in the top GRS third tile than for those in the bottom third tile (95% CI = 2.99–8.18; P < 0.001). The addition of genetic information improved DR prediction, increasing the area under the curve (AUC) from 0.72 to 0.77 (P = 0.0024) and improving the sensitivity of the model such that 40 more subjects were reclassified into DR status. The developed multivariate logistic regression model combining conventional risk factors and the multilocus GRS can predict DR, thus enabling timely treatment to reduce blindness in T2D patients.

show abstract

“…Some polymorphisms of the TCF7L2 gene were known to have a role in the development of DR. Ciccacci et al observed that patients with rs12255372 or rs7903146 polymorphisms in TCF7L2 had a more chance for developing DR (73). In a meta-analysis by Ding et al, they found that the rs7903146 (T allele in TCF7L2) was significantly correlated with the elevated risk of DR (P ≤ 0.001) (74). Ma et al reported that Pro12Ala polymorphism of the peroxisome proliferatoractivated receptor γ2 (PPARγ2) gene is another effective polymorphism on the development of DR (75).…”

Section: Genetic Polymorphismsmentioning

confidence: 99%

Evaluating the Risk Factors of Development and Progression of Diabetic Retinopathy: A Review Study

Rasoulinejad

2022

Shiraz E-Med J

View full text Add to dashboard Cite

: Diabetes is a chronic, underlying, and common disease worldwide that imposes an enormous burden on the health system. Diabetic retinopathy (DR) is a serious complication in the eye caused by diabetes and may lead to visual impairment and blindness. The knowledge about the risk factors of DR is critical for the prevention of disease and developing treatment options. Moreover, DR is a multifactorial disease, and many studies have demonstrated various risk factors associated with it, such as hyperglycemia, hypertension, hyperlipidemia, etc. In this review study, we survey the main risk factors of the development and progression of DR.

show abstract

Association between transcription factor 7-like 2 rs7903146 polymorphism and diabetic retinopathy in type 2 diabetes mellitus: A meta-analysis

Cited by 10 publications

References 51 publications

Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with type 2 diabetes mellitus in Chinese Korean ethnicity population

Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with type 2 diabetes mellitus in Chinese Korean ethnicity population

Multilocus genetic risk score for diabetic retinopathy in the Han Chinese population of Taiwan

Evaluating the Risk Factors of Development and Progression of Diabetic Retinopathy: A Review Study

Contact Info

Product

Resources

About