Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with type 2 diabetes mellitus in Chinese Korean ethnicity population

Abstract

Presently, data on the type 2 diabetes mellitus (T2DM) in Chinese Korean ethnicity are very scarce. This study aimed to explore the relationship between the transcription factor 7-like 2 (TCF7L2) and T2DM in Chinese Korean ethnicity population. This case-control study involved 43 T2DM Chinese Korean ethnicity patients (T2DM group) and 43 healthy Chinese Korean ethnicity normoglycemic subjects as controls (Control group). All included participants aged from 40 to 75 years old. Clinical and biological data were collected to determine the phenotypic traits. The restriction fragment length polymorphism-polymerase chain reaction was used to analyze the TCF7L2 by genotyping for rs7903146 (C/T). Spectrophotometer with Chronolab kits was used to conduct the biochemical analyses. TCF7L2 was associated with T2DM in the Chinese Korean ethnicity population ( P < .01 for alleles, and P < .05 for genotypes). Significant differences were found 2 groups regarding the T allele (37.2% T2DM patients vs 15.1% healthy subjects, P < .01), and G allele (62.8% T2DM patients vs 84.9% healthy subjects, P < .01). The risk genotypes were GG (83.7% T2DM patients, vs 44.2% healthy control, P < .01), GT (4.7% T2DM patients, vs 20.9% healthy control, P = .04), and TT (11.6% T2DM patients, vs 34.9% healthy control, P = .01). The results of this study demonstrated that TCF7L2 is associated with T2DM in the Chinese Korean ethnicity population, which is an important risk factor for T2DM in this population.

Association of gene polymorphisms with body weight changes in prediabetic patients

“…In particular, in the present study of the Russian population, we revealed that the T allele of this polymorphism is more common in the participants with prediabetes, T2D and obesity. The same results were shown in a number of other studies, which demonstrate the association of TCF7L2 rs7903146 with T2D in across many ethnic populations [21][22][23]. However, there appears to be no significant association between the T allele of TCF7L2 rs7903146 and T2D risk in Chinese population [24].…”

RETRACTED ARTICLE: Haplotype analysis on correlation between transcription factor 7-like 2 gene polymorphism and breast cancer risk

“…The transcription factor 7-like 2 ( TCF7L2 ) gene is located at human chromosome 10q25.3, 215.9 kb long, with 17 identified extrons. Previous studies have showed the relationship between TCF7L2 gene and common diseases such as type 2 diabetes mellitus (T2DM) [ 9 ], diabetic nephropathy (DN) [ 10 ], nonalcoholic fatty liver [ 11 ] and some cancers [ 12 , 13 ]. The relationship between single nucleotide polymorphism (SNPs) of TCF7L2 gene and BC risk was also reported in German [ 14 ], Hispanic [ 15 ], United States [ 16 , 17 ] and Chinese population [ 18 ].…”

Association of gene polymorphisms with body weight changes in prediabetic patients

“…In particular, in the present study of the Russian population, we revealed that the T allele of this polymorphism is more common in the participants with prediabetes, T2D and obesity. The same results were shown in a number of other studies, which demonstrate the association of rs7903146 TCF7L2 with T2D in across many ethnic populations [19][20][21]. However, there appears to be no signi cant association between the T allele of rs7903146 TCF7L2 and T2D risk in Chinese population [22].…”