Association between three functional microRNA polymorphisms (miR-499 rs3746444, miR-196a rs11614913 and miR-146a rs2910164) and breast cancer risk: a meta-analysis

Abstract

Three functional microRNA polymorphisms (miR-499 rs3746444 A > G, miR-196a rs11614913 C > T and miR-146a rs2910164 G > C) have been reported to be associated with breast cancer (BC) risk. However, the results of the published studies are inconsistent. In order to obtain a more credible result, we conducted this meta-analysis. We searched PubMed, EMBASE and Web of Science databases to identify relevant studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the association. Thirty-eight eligible studies with 17,417 cases and 18,988 controls were included in this meta-analysis. Our results showed that the rs3746444 was associated with an increased breast cancer risk in the four genetic models (G vs. A: OR = 1.17, P = 0.008; GG vs. AA: OR = 1.41, P < 0.001; AG vs. AA: OR = 1.10, P = 0.036; GG+AG vs. AA: OR = 1.16, P = 0.001). In the subgroup analysis by ethnicity, significant correlation remained in Asians but not in Caucasians. For rs11614913, obvious decreased breast cancer risk was observed in Caucasian populations (T vs. C: OR = 0.93, P = 0.044). However, we couldn't detect an association between rs2910164 and breast cancer risk. This meta-analysis demonstrates that rs3746444 could increase breast cancer risk in Asians and in general populations, while rs11614913 could decrease the risk of breast cancer in Caucasians. The rs2910164 polymorphism has no association with breast cancer risk. More multicenter studies with larger sample sizes are required to verify our results.

Association between MIR499A rs3746444 polymorphism and breast cancer susceptibility: a meta-analysis

“…Therefore, the association of MIR499A rs3746444 polymorphism with breast cancer susceptibility among non-Asian populations remained unclear. Nevertheless, a major strength of the present work is that it included a larger number of studies and subjects compared to previous reports on this topic 45,46 . Thus, the present meta-analysis provided an updated and integrated estimate of the association between the polymorphism and breast cancer risk.…”

A genetic variant in microRNA-146a is associated with sporadic breast cancer in a Southern Brazilian Population

“…Also evidencing the differences of the effect of rs2910164 on the risk of BC in diverse populations, the allele rs2910164G was associated with increased risk of sporadic BC in Australians (OR =1.77, p < 10 -4 ; Uphadhyaya et al, 2015) and Iranians (OR = 1.91, p = 0.03; Barjui et al, 2017). Other studies, on the other hand, reported no association (Zhang et al, 2016;Mu et al, 2017).…”

Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta‐analysis

“…All four miRNA gene variant associations noteworthy to detect an OR of 1.1 that were also noteworthy (FPRP < 0.2) were included in these 16 comparisons. The other 12 comparisons were miR‐196a2/rs11614913 T vs. C (OR, 1.21; P < .0001); miR‐27a/rs895819 GG vs. AA + AG (OR, 1.49, P < .001) and colorectal cancer ; miR‐196a2/rs11614913 C vs. T (OR, 1.40, P < .00001) and oesophageal cancer ; miR‐146a/rs2910164 G vs. C (OR, 1.15, P < .001); miR‐196a2/rs11614913 T vs. C (OR, 0.77, P < .00001) and gastric cancer ; miR‐146a/rs2910164 C vs. G (OR, 1.19, P < .001) and bladder cancer ; miR‐499/rs3746444 homozygous model (OR, 1.64, P < .001) and breast cancer ; miR‐146a/rs2910164 CC vs. GG + GC (OR, 0.52, P < .001); miR‐499/rs3746444 (OR, 2.07, P < .001) and cervical cancer ; miR‐499/rs3746444 GA vs. AA (OR, 1.60, P < .001) and prostate cancer ; miR‐146a/rs2910164 CC vs. GG (OR, 1.28, P < .001) and lung cancer ; and miR‐499/rs3746444 G vs. A (OR, 1.57, P < .001) and oral squamous cell cancer …”