Association between MIR499A rs3746444 polymorphism and breast cancer susceptibility: a meta-analysis

Tan, Shing Cheng; Lim, Poh Ying; Fang, Jie; Mokhtar, Mira Farzana Mohamad; Hanif, Ezanee Azlina Mohamad; Jamal, Rahman

doi:10.1038/s41598-020-60442-3

Cited by 15 publications

(13 citation statements)

References 44 publications

(57 reference statements)

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“…Allele C of rs11614913 in hsa-miR-196a-3p was found to be significantly associated with decreased risk of BC (C vs. T: OR = 0.64, 95%CI = 0.49-0.85, p = 0.0019) [42]. Allele G of rs3746444 in seed region of hsa-miR-499a-3p significantly increased BC susceptibility only among Asians (G vs. A: OR = 1.12, 95% CI = 1.00-1.26, P = 0.04) [43]. The G allele rs4919510 in hsa-miR-608 decreased the risk of BC (G vs. C: OR = 0.53, 95%CI 0.30-0.92, p = 0.024) [44].…”

Section: Discussionmentioning

confidence: 98%

Predicting SNPs in Mature MicroRNAs Dysregulated in Breast Cancer

Nguyen¹,

Nguyen²,

Huynh³

et al. 2022

Recent Advances in Noncoding RNAs

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Breast cancer (BC) is the leading type of cancer among women. Findings have revolutionized current knowledge of microRNA (miRNA) in breast tumorigenesis. The seed region of miRNA regulates the process of gene expression negatively. The presence of SNPs in the seed regions of miRNA dramatically alters the mature miRNA function. Additionally, SNPs in the out-seed region of miRNAs have a significant impact on miRNA targeting. This study focuses on the in silico analysis procedure of mature miRNA SNPs and their impact on BC risk. The database annotated SNPs on mature miRNAs was used. Also, target gene alterations, miRNAs function in BC, and the interaction of miRNAs with targets were predicted. A list of 101 SNPs in 100 miRNAs with functional targets in BC was indicated. Under the SNPs allele variation, 10 miRNAs changed function, 6 miRNAs lost targets, 15 miRNAs gained targets, 48 onco-miRNAs remained unchanged, and 21 tumor suppressor miRNAs remained unchanged. At last, a list of 89 SNPs, which alter miRNA function and miRNA-mRNA interaction, were shown to be potentially associated with BC risk. This research theoretically generated a list of possible causative SNPs in the mature miRNA gene that might be used in future BC management studies.

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Section: Discussionmentioning

confidence: 98%

Predicting SNPs in Mature MicroRNAs Dysregulated in Breast Cancer

Nguyen¹,

Nguyen²,

Huynh³

et al. 2022

Recent Advances in Noncoding RNAs

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“…On the other hand, Rodriguez-Hernandez et al [ 41 ] showed that there was no significant association between the polymorphism and glioma risk. These inconsistencies could be due to numerous factors, such as the ethnicity of the study population, and the sample size (and thus statistical power) of the studies [ 70 , 71 ]. A well-conducted meta-analysis is essential to address these inconsistencies.…”

Section: Discussionmentioning

confidence: 99%

Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: A systematic review and meta-analysis

Tan

Low²,

Hussain³

et al. 2022

PLoS ONE

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Background The XRCC3 p.Thr241Met (rs861539) polymorphism has been extensively studied for its association with glioma risk, but results remain conflicting. Therefore, we performed a systematic review and meta-analysis to resolve this inconsistency. Methods Studies published up to June 10, 2022, were searched in PubMed, Web of Science, Scopus, VIP, Wanfang, and China National Knowledge Infrastructure databases and screened for eligibility. Then, the combined odds ratio (OR) of the included studies was estimated based on five genetic models, i.e., homozygous (Met/Met vs. Thr/Thr), heterozygous (Thr/Met vs. Thr/Thr), dominant (Thr/Met + Met/Met vs. Thr/Thr), recessive (Met/Met vs. Thr/Thr + Thr/Met) and allele (Met vs. Thr). The study protocol was preregistered at PROSPERO (registration number: CRD42021235704). Results Overall, our meta-analysis of 14 eligible studies involving 12,905 subjects showed that the p.Thr241Met polymorphism was significantly associated with increased glioma risk in both homozygous and recessive models (homozygous, OR = 1.381, 95% CI = 1.081–1.764, P = 0.010; recessive, OR = 1.305, 95% CI = 1.140–1.493, P<0.001). Subgroup analyses by ethnicity also revealed a statistically significant association under the two aforementioned genetic models, but only in the Asian population and not in Caucasians (P>0.05). Conclusion We demonstrated that the XRCC3 p.Thr241Met polymorphism is associated with an increased risk of glioma only in the homozygous and recessive models.

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“…A recent meta-analysis study showed that the MIR499A rs3746444 G allele is associated with high risk of developing breast cancer [ 52 ]. The allele G was also associated with hepatocellular carcinoma [ 53 ], and adenocarcinoma [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Variants of MIRNA146A rs2910164 and MIRNA499 rs3746444 are associated with the development of cutaneous leishmaniasis caused by Leishmania guyanensis and with plasma chemokine IL-8

et al. 2021

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Leishmania are intracellular protozoan parasites that cause a wide spectrum of clinical manifestations in genetically susceptible individuals with an insufficient or balanced Th1 immune response to eliminate the parasite. MiRNAs play important regulatory role in numerous biological processes including essential cellular functions. miR146-a acts as an inhibitor of interleukin 1 receptor associated kinase 1 (IRAK1) and tumour necrosis factor (TNF) receptor associated factor 6 (TRAF6) present in the toll-like receptors pathway while miR499a modulates TGF-β and TNF signalling pathways. Here, we investigated whether MIRNA146A rs2910164 and MIRNA499 rs3746444 variants are associated with the development of L. guyanensis (Lg)-cutaneous leishmaniasis (CL). The variants MIR146A rs2910164 and MIR499A rs3746444 were assessed in 850 patients with Lg-CL and 891 healthy controls by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Plasma cytokines were measured using the BioPlex assay. Carriers of rs2910164 CC genotype have 30% higher odds of developing CL (ORadjage/sex = 1.3 [95%CI 0.9–1.8]; Padjage/sex 0.14) compared to individuals with the genotype GG (ORadjage/sex = 0.77 [95%CI 0.56–1.0]; Padjage/sex 0.14) if exposed to Lg-infection. Heterozygous GC individuals also showed lower odds of developing CL (ORadjage/sex = 0.77 [95%CI 0.5–1.1]; Padjage/sex 0.09). Homozygosity for the allele C is suggestive of an association with the development of Lg-CL among exposed individuals to Lg-infection. However, the odds of developing CL associated with the CC genotype was evident only in male individuals (ORadjage = 1.3 [95% CI = 0.9–2.0]; Padjage = 0.06). Individuals homozygous for the G allele tend to have higher plasma IL-8 and CCL5. Similarly, for the MIR499A rs3746444, an association with the G allele was only observed among male individuals (OR = 1.4 [1.0–1.9]; P = 0.009). In a dominant model, individuals with the G allele (GG-GA) when compared to the AA genotype reveals that carriers of the G allele have 40% elevated odds of developing Lg-CL (ORadjage = 1.4 [1.1–1.9]). Individuals with the GG genotype have higher odds of developing Lg-CL (ORadjage/sex = 2.0 [95%CI 0.83–5.0]; Padjage = 0.01. Individuals homozygous for the G allele have higher plasma IL-8. Genetic combinations of both variants revealed that male individuals exposed to Lg bearing three or four susceptible alleles have higher odds of developing Lg-CL (OR = 2.3 [95% CI 1.0–4.7]; p = 0.017). Both MIR146A rs2910164 and MIR499A rs3746444 are associated with the development of Lg-CL and this association is prevalent in male individuals.

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Association between MIR499A rs3746444 polymorphism and breast cancer susceptibility: a meta-analysis

Cited by 15 publications

References 44 publications

Predicting SNPs in Mature MicroRNAs Dysregulated in Breast Cancer

Predicting SNPs in Mature MicroRNAs Dysregulated in Breast Cancer

Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: A systematic review and meta-analysis

Variants of MIRNA146A rs2910164 and MIRNA499 rs3746444 are associated with the development of cutaneous leishmaniasis caused by Leishmania guyanensis and with plasma chemokine IL-8

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