Association between the Ser128Arg variant of the E-selectin and risk of coronary artery disease in the central China

Li, Yan; Wei, Ye‐Sheng; Wang, Ming; Zhang, Pingan; Jiang, Xuejun; Huang, Cong-Xin

doi:10.1016/j.ijcard.2004.07.011

Cited by 22 publications

(17 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are in agreement with those reported by Li and colleagues,21 who found the distribution of the AA and AC genotypes were 93.8% and 6.2% in the control subjects, respectively and 86.7% and 13.3% in patients with CAD, respectively. In the study of Yoshida and colleagues,8 the frequency of Arg128-positive was significantly higher in patients than in the controls (12.6% versus 6.7%).…”

Section: Discussionsupporting

confidence: 93%

Role of ICAM-1 and E-selectin gene polymorphisms in pathogenesis of PAOD in Egyptian patients

Shaker

Zahra²,

Sayed³

et al. 2009

VHRM

View full text Add to dashboard Cite

Background:Intercellular adhesion molecule-1 (ICAM-1) and E-selectin have been shown to predict cardiovascular disease (CVD) such as myocardial infarction, stroke, and peripheral arterial occlusive disease (PAOD).Methods:Two mutations, S128R in E-selectin and K469E in ICAM-1, were investigated in 156 patients with PAOD and 100 control subjects using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in an Egyptian population.Results:The distribution of E-selectin genotypes in patients affected by PAOD was 84.6% for the AA genotype and 15.4% for the AC genotype. In the control arm the distribution was 97% for the AA genotype and 3% for the AC genotype. There was a statistically significance difference in the distribution of the AC genotype in PAOD patients when compared with the control subjects. Additionally, the distribution of ICAM-1 genotypes in patients affected by PAOD was 30.8% with the EE, 48% with the EK, and 21.2% with the KK genotypes. The distribution of ICAM-1 genotypes in control subjects was 13% EE, 33% EK and 54% KK. The EE genotype was significantly more common in PAOD patients than in the controls.Conclusion:S128R and K469E polymorphisms were associated with increased risk in PAOD. Early detection of these polymorphic genes helps in early prophylaxis against PAOD.

show abstract

Section: Discussionsupporting

confidence: 93%

Role of ICAM-1 and E-selectin gene polymorphisms in pathogenesis of PAOD in Egyptian patients

Shaker

Zahra²,

Sayed³

et al. 2009

VHRM

View full text Add to dashboard Cite

show abstract

“…The relationship of between A561C polymorphism of E-selectin gene and CAD was evaluated in numerous studies (17)(18)(19)(20)(21). In contradiction with our results, Tripathi et al reported that S128R polymorphism in E-selectin gene in Indian peoples has no relationship with CAD (17).…”

Section: Discussioncontrasting

confidence: 99%

“…Contrarily, Li et al reported that the presence of allele C in A561C polymorphism was associated with CAD in a Chinese population (19). A significant association between C allele and CAD was observed in Arab patients (20).Furthermore, it was shown in a Japanese population that substitution of Ser with Arg in EGF domain of E-selectin may be a risk factor for severe atherosclerosis (21).…”

Section: Discussionmentioning

confidence: 99%

Association Between A561C Polymorphism of E-Selectin Gene and Coronary Arterial Disease in Southeastern Iranian Population

et al. 2013

View full text Add to dashboard Cite

Background: Numerous factors including genetic factors play a role in pathogenesis of coronary atherosclerosis. It has been reported that polymorphisms of genes encoding adhesion molecules are associated with atherosclerosis. Objectives: The present research aimed to evaluate A561C polymorphism of the E-selectin gene in patients with coronary arterial diseases (CAD). Materials and Methods: Eighty seven CAD patients and 93 age-and sex-matched control subjects were enrolled in this research. The polymorphism of A561C in the E-selectin gene was defined by polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP). Results: The prevalence's of AA, AC and CC genotypes were 55.2%, 24.1% and 20.7% in CAD patients and 51.6%, 40.9% and 7.5% in the control subjects, respectively. The frequencies of the C allele were significantly higher in CAD patients compared with control groups (P < 0.05). Logistic regression analysis revealed a significant association between the C allele and the risk of CAD (OR = 1.61, 95%CI = 1.03-2.51). Conclusions: Our results displayed that presence of C allele at position 561 E-selection gene is associated with increased risk of atherosclerosis disease in the southeastern Iranian population. This polymorphism may be able to affect leukocyte-endothelial interactions, which may account for the pathogenesis of atherosclerosis.

show abstract

“…Our previous study involving ischemic stroke patients and controls revealed AC genotype to be a significant risk factor, additionally there was absence of CC genotype which was similar to the earlier findings among coronary artery disease (CAD) patients of North Indian origin [30]. This finding is also in accordance with reports from populations of Chinese and Japanese origin [31,32]. In contrast to these reports a study by Abu-Amero et al [33] documents the CC (RR) genotype to be significantly higher among CAD patients.…”

Section: Discussionsupporting

confidence: 90%

E-selectin gene (S128R) polymorphism in hemorrhagic stroke: Comparison with ischemic stroke

Das

Roy

Kaul

et al. 2014

Neuroscience Letters

View full text Add to dashboard Cite

Association between the Ser128Arg variant of the E-selectin and risk of coronary artery disease in the central China

Cited by 22 publications

References 24 publications

Role of ICAM-1 and E-selectin gene polymorphisms in pathogenesis of PAOD in Egyptian patients

Role of ICAM-1 and E-selectin gene polymorphisms in pathogenesis of PAOD in Egyptian patients

Association Between A561C Polymorphism of E-Selectin Gene and Coronary Arterial Disease in Southeastern Iranian Population

E-selectin gene (S128R) polymorphism in hemorrhagic stroke: Comparison with ischemic stroke

Contact Info

Product

Resources

About