Association between the polymorphisms of CALM1 gene and osteoarthritis risk: a meta-analysis based on observational studies

Abstract

The existing studies on the association between polymorphisms of Calmodulin 1 (CALM1) gene and the risk of osteoarthritis (OA, a complex multifactorial disease and a major degenerative form of arthritis) in different populations have yielded conflicting findings. Therefore, we conducted a meta-analysis by systematically searching PubMed, Embase, Medline, Cochrane Library and Google Scholar, and assessing this association by calculating pooled odds ratios with 95% confidence intervals. Subgroup analyses stratified by ethnicity, OA type, and genotype were also conducted. Six studies (2752 cases and 3259 controls) involving six single nucleotide polymorphisms were included. Our data suggested that the T allele and genotype TT of the rs12885713 polymorphism, and the C allele of the rs2300496 polymorphism in the CALM1 gene all increased the risk of OA. The pooled results revealed no significant association between the CALM1 rs3213718 polymorphism and the risk of OA. Stratification analyses by ethnicity and OA type showed that the rs12885713 polymorphism increased the risk of OA among Asians and in knee OA, respectively. In conclusion, the rs12885713 and rs2300496 polymorphisms of the CALM1 gene may both increase the risk of OA. Owing to the limitations of the present study, this finding should be further confirmed in future well-designed studies.

Genetic markers of osteoarthritis: early diagnosis in susceptible Pakistani population

“…This results in decreased expression of matrix genes, and hence, chondrocytes are unable to respond to mechanical stress. This genotype has been found associated with hip OA (HOA) in the Japanese population and associated to OA in a meta-analysis done using six-control case studies [14,16]. However, a similar study done on British population and five case-control studies meta-analysis revealed no association with it [17,18].…”

Role of SREBP2 gene polymorphism on knee osteoarthritis in the South Indian Hyderabad Population: A hospital based study with G595C variant

“…Osteoarthritis (OA; OMIM 165720) is documented as the basic form of arthritis and can originate from progressive loss of joint function. 1 Disjoint of hip and knee leads to the major cause of pain, functional loss, and poor quality of life. 2 It is also documented as a late-onset musculoskeletal disease in the elder population, characterized by gradual degradation of the articular cartilage by additional synovium injury, subchondral, and other types of bone-joint tissue.…”

Genetic polymorphisms associated with the development of arrhythmic type of cardiovascular events

“…Одним из наиболее часто встречающихся первичных клинических проявлений дисфункции миокарда считают различные варианты аритмий [4]. К опасным состояниям для пациентов, находящихся в процессе терапии противоопухолевыми препаратами, следует отнести удлинение интервала QT, расстройство электрической активности сердца [5].…”