Association between the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to preeclampsia: the need for data clarification in a recent meta-analysis

Xuan, Chao; Liu, Limin

doi:10.1038/hr.2012.211

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Heterozygosity and homozygosity are associated neither with higher total Hcy nor lower folate plasma concentration. The MTHFR gene polymorphisms are directly linked with many diseases 20 74 . Our recent meta-analysis demonstrated that the MTHFR C677T polymorphism is associated with the risk of myocardial infarction in young/middle-aged Caucasians and is associated with susceptibility to preeclampsia 20 74 .…”

Section: Discussionmentioning

confidence: 99%

“…Allele frequencies for the MTHFR (C677T and A1298C) polymorphisms from each study were determined by the allele counting method 18 . The genotype distributions of controls were used to estimate the frequency of the putative risk allele (-677T and -1298C) using the inverse variance method 19 20 . The Hardy-Weinberg Equilibrium ( HWE ) is the most fundamental rule of population genetics.…”

Section: Methodsmentioning

confidence: 99%

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Association Between MTHFR Polymorphisms and Congenital Heart Disease: A Meta-analysis based on 9,329 cases and 15,076 controls

Xuan

Zhao

et al. 2014

Sci Rep

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The aim of our study was to evaluate the association between polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and the risk for congenital heart disease (CHD). Electronic literature databases were searched to identify eligible studies published before Jun, 2014. The association was assessed by the odds ratio (OR) with a 95% confidence interval (CI). The publication bias was explored using Begg's test. Sensitivity analysis was performed to evaluate the stability of the crude results. A total of 35 studies were included in this meta-analysis. For the MTHFR C677T polymorphism, we detected significant association in all genetic models for Asian children and the maternal population. Significant association was also detected in T vs. C for a Caucasian paediatric population (OR = 1.163, 95% CI: 1.008–1.342) and in both T vs. C (OR = 1.125, 95% CI: 1.043–1.214) and the dominant model (OR = 1.216, 95% CI:b1.096–1.348) for a Caucasian maternal population. For the MTHFR A1298C polymorphism, the association was detected in CC vs. AC for the Caucasian paediatric population (OR = 1.484, 95% CI: 1.035–2.128). Our results support the MTHFR -677T allele as a susceptibility factor for CHD in the Asian maternal population and the -1298C allele as a risk factor in the Caucasian paediatric population.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Association Between MTHFR Polymorphisms and Congenital Heart Disease: A Meta-analysis based on 9,329 cases and 15,076 controls

Xuan

Zhao

et al. 2014

Sci Rep

Self Cite

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Response to Xuan

2013

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We are grateful to the author who shared his comments and suggestions 1 regarding several issues of our meta-analysis 2 to the editor. After carefully reviewing the authors' comments and checking the raw data and our original article, we are pleased to reply to and/or clarify his questions point by point. First, because a departure from the Hardy-Weinberg equilibrium (HWE) in controls may indicate the existence of migration, selection and mutation in population terms, which may imply poor study quality, we excluded studies that are not in HWE from our meta-analysis. The author mentioned that there were three articles that did not deviate significantly from the HWE. 3-5 After recalculation, we found that these three articles are in HWE (P ¼ 0.066, P ¼ 0.129, P ¼ 0.078). Thus, as the author said, these three articles should have been included. Second, the author mentioned that there were 15 additional articles that should have been included in our meta-analysis. 3-17 After researching for articles relative to the association between C677T polymorphism and pre-eclampsia (PE), we found only four of the articles mentioned by the author. 3-6 Therefore, these four studies should have been included in our meta-analysis. 3-6 Another four of the studies had incomplete data and should not have been included because only data for allele T and TT genotype were provided. 7-10 Furthermore, another seven articles were not included because they did not refer to the association between the MTHFR C677T polymorphism and PE. 11-17 Otherwise, we found one other study that should also have been included in our meta-analysis. 18 And so, these five studies should have been included. 3-6,18 Third, the author stated that their previous study indicated that the À677T frequencies of the MTHFR gene were different between East Asian (China, Japan and Korea) and South Asian (India) populations. 19 We read the meta-analysis that analyzed the relationship between the MTHFR C677T

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Association of methylenetetrahydrofolate reductase C677T polymorphism with the pre-eclampsia risk in Hakka pregnant women in Southern China

Hou

Lin

Guo

et al. 2019

Gynecological Endocrinology

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Association between the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to preeclampsia: the need for data clarification in a recent meta-analysis

Cited by 4 publications

References 17 publications

Association Between MTHFR Polymorphisms and Congenital Heart Disease: A Meta-analysis based on 9,329 cases and 15,076 controls

Association Between MTHFR Polymorphisms and Congenital Heart Disease: A Meta-analysis based on 9,329 cases and 15,076 controls

Response to Xuan

Association of methylenetetrahydrofolate reductase C677T polymorphism with the pre-eclampsia risk in Hakka pregnant women in Southern China

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