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An active role of T regulatory cells (Treg) and tolerogenic dendritic cells (Tol-DC) is believed important for the induction and maintenance of transplantation tolerance. However, interactions between these cells remain unclear. We induced donor-specific tolerance in a fully MHC-mismatched murine model of cardiac transplantation by simultaneously targeting T cell and DC function using anti-CD45RB mAb and LF 15-0195, a novel analog of the antirejection drug 15-deoxyspergualin, respectively. Increases in splenic Treg and Tol-DC were observed in tolerant recipients as assessed by an increase in CD4+CD25+ T cells and DC with immature phenotype. Both these cell types exerted suppressive effects in MLR. Tol-DC purified from tolerant recipients incubated with naive T cells induced the generation/expansion of CD4+CD25+ Treg. Furthermore, incubation of Treg isolated from tolerant recipients with DC progenitors resulted in the generation of DC with Tol-DC phenotype. Treg and Tol-DC generated in vitro were functional based on their suppressive activity in vitro. These results are consistent with the notion that tolerance induction is associated with a self-maintaining regulatory loop in which Tol-DC induce the generation of Treg from naive T cells and Treg programs the generation of Tol-DC from DC progenitors.

The Chinese Altai, a typical region of the Central Asian Orogenic Belt (CAOB), has been envisaged as subduction‐accretion complex or Precambrian microcontinent. Thick metasedimentary rocks crop out extensively in the Central Altai and Qiongkuer domains, but their depositional age is not well constrained. Most workers have regarded these sedimentary rocks as passive continental margin sediments deposited on a Precambrian microcontinent. However, our studies of U‐Pb and Hf isotopes of detrital zircons separated from these rocks reveal that a predominant population has 206Pb/238U ages between 460 and 540 Ma and most grains of this population possess positive ɛHf(t) values. Zircons of the population have oscillatory zoning, possess high Th/U ratios, and are enhedral to subhedral crystals with sharp edges, showing short distance of transportation from an igneous provenance. The above results indicate that these metasedimentary rocks were deposited on an active continental margin not prior to the Middle Ordovician. Therefore the Chinese Altai orogen was an active continental margin in the Early Paleozoic, which is inconsistent with a Precambrian microcontinent model and reveals an arc accretionary history.

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