Association of methylenetetrahydrofolate reductase C677T polymorphism with the pre-eclampsia risk in Hakka pregnant women in Southern China

Hou, Jingyuan; Lin, Lei; Guo, Wei; Luo, Dandan; Lan, Liubing

doi:10.1080/09513590.2019.1658188

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…In normal populations, the frequency of TT homozygotes is approximately 4% in Egyptian ( 10 ) and approximately 23% in Italians in Europe ( 11 ), while the T allele frequency is at a higher level of 41% in the Chinese population ( 8 ). According to Hou ( 12 ), the T allele frequency of healthy pregnant women is 27%. But our study showed that the frequency of the T allele in the GH group was 53.8%, and the frequency of the T allele in the PE renal function impairment group was 60.4%, both of which were higher than those reported above and similar to the findings of Ding et al ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

C677T Gene Polymorphism of MTHFR Is a Risk Factor for Impaired Renal Function in Pregnant Women With Preeclampsia in the Chinese Han Population

Lin

Ge²,

Xu³

et al. 2022

Front. Cardiovasc. Med.

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Impaired renal function in pregnant women with preeclampsia is particularly common, yet there is no consensus about implementation. This lack of consensus is due in part to uncertainty about risks for disease progression. Limited evidence suggests that C677T gene polymorphism of 5, 10-methylenetetrahydrofolate reductase (MTHFR C677T) may affect impaired renal function in pregnant women with preeclampsia in Chinese Han population. To investigate the association between MTHFR C677T and impaired renal function in pregnant women with preeclampsia, a total of 327 pregnant women diagnosed with gestational hypertension (GH) or preeclampsia-eclampsia (PE) from January 2016 to December 2021 were selected as the study subjects. The personal information, gestational information, clinical indicators, and the C677T gene polymorphism of MTHFR were tested. Compared with the GH group, the PE renal function impairment group had increased in blood pressure, homocysteine level, liver and kidney function indicators (creatinine, uric acid, urea nitrogen, cystatin C, alanine aminotransferase, aspartate aminotransferase, cholyglycine), and blood lipids (total cholesterol, triglycerides and low density lipoprotein) but had reductions in plasma protein (total protein, albumin, globulin, prealbumin), trace elements (calcium and zinc), prothrombin time and fibrinogen. The homocysteine level in the TT genotype was higher than that in the CC and CT genotypes. Binary logistic regression analysis showed that the MTHFR C677T gene polymorphism was associated with PE renal function impairment in the recessive model (OR: 1.620, 95% CI: 1.033–2.541, P < 0.05). These findings show that the C677T gene polymorphism of MTHFR is an independent risk factor for impaired renal function in pregnant Chinese Han women with PE.

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Section: Discussionmentioning

confidence: 99%

C677T Gene Polymorphism of MTHFR Is a Risk Factor for Impaired Renal Function in Pregnant Women With Preeclampsia in the Chinese Han Population

Lin

Ge²,

Xu³

et al. 2022

Front. Cardiovasc. Med.

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“…Azimi‐Nezhad et al 74 also reported a higher frequency of the C677T CT genotype in Iranian PE women than that in controls. A study from China found no statistically significant differences in the C677T genotype or allele frequency among Hakka PE women but observed that women with the CC genotype had lower serum HCY levels than women with other genotypes 75 …”

Section: Genetic Polymorphisms Of Pihmentioning

confidence: 96%

“…A study from China found no statistically significant differences in the C677T genotype or allele frequency among Hakka PE women but observed that women with the CC genotype had lower serum HCY levels than women with other genotypes. 75 2.4.4 | MMP9 gene Matrix metalloproteinases (MMP) are zinc-dependent endopeptidases that can selectively degrade several components of the extracellular matrix (ECM). 76 MMP-9, one of the potent hydrolases secreted by trophoblast cells, digests ECM before trophoblast invasion and is involved in ECM remodeling and arterial transformation during placental angiogenesis.…”

Section: Mthfr Genementioning

confidence: 99%

The genetic risk factors for pregnancy‐induced hypertension: Evidence from genetic polymorphisms

et al. 2022

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Pregnancy‐induced hypertension (PIH) is a multifactorial and severe pregnancy complication including preeclampsia/eclampsia, gestational hypertension, chronic (pre‐existing) hypertension, and preeclampsia/eclampsia variants superimposed on chronic hypertension. PIH‐induced maternal mortality accounts for approximately 9% of all maternal deaths over the world. A large number of case‐control studies have established the importance of various genetic factors in the occurrence and development of PIH. In this narrative review, we summarized the genetic risk factors involved in the renin‐angiotensin system, endothelin system, inflammatory factors, oxidative stress, and other functional networks, with the aim of sorting out the genetic factors that may play a potential role in PIH and providing new ideas to elucidate the pathogenesis of PIH.

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Epigenetic alterations in preeclampsia: a focus on microRNA149 and tetrahydrofolate reductase gene polymorphisms in Egyptian women

Ellakwa,

Rashed,

El-Mandoury

et al. 2024

Ir J Med Sci

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Association of methylenetetrahydrofolate reductase C677T polymorphism with the pre-eclampsia risk in Hakka pregnant women in Southern China

Cited by 4 publications

References 36 publications

C677T Gene Polymorphism of MTHFR Is a Risk Factor for Impaired Renal Function in Pregnant Women With Preeclampsia in the Chinese Han Population

C677T Gene Polymorphism of MTHFR Is a Risk Factor for Impaired Renal Function in Pregnant Women With Preeclampsia in the Chinese Han Population

The genetic risk factors for pregnancy‐induced hypertension: Evidence from genetic polymorphisms

Epigenetic alterations in preeclampsia: a focus on microRNA149 and tetrahydrofolate reductase gene polymorphisms in Egyptian women

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