Association between the IL1B, IL1RN polymorphisms and COPD risk: A meta-analysis

Abstract

The interleukin-1 (IL-1) gene polymorphisms have been implicated in chronic obstructive pulmonary disease (COPD) risk, but results are controversial. We aimed to conduct a meta-analysis to address this issue. Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association. The meta-analysis revealed no association between the IL1B (−511), (−31), (+3954) polymorphisms and COPD risk. However, stratification by ethnicity indicated that the T allele carriers of the IL1B (−511) polymorphism and the C allele carriers of the IL1B (−31) variant were associated with an increased risk for developing COPD in East Asians (OR = 1.61, 95% CI: 1.13–2.31, Pz = 0.009 and OR = 1.55, 95% CI: 1.14–2.11, Pz = 0.006, respectively). The meta-analysis revealed a significant association between the IL1RN (VNTR) polymorphism and COPD risk in all study subjects and East Asians under homozygote model (22 vs. LL: OR = 3.16, 95% CI: 1.23–8.13, Pz = 0.017 and OR = 3.20, 95% CI: 1.13–9.12, Pz = 0.029, respectively). Our meta-analysis suggests that the IL1B (−511), (−31) and IL1RN (VNTR) polymorphisms are associated with COPD risk in East Asians. There is no association between the IL1B (+3954) polymorphism and COPD risk. Further studies should be performed in other ethnic groups besides East Asians.

Correlation between magnetism and “dark stripes” in strained La1−xSrxCoO3 epitaxial films (0 ≤ x ≤ 0.1)

“…For the films with a x between 0 and 0.5, however, the combined tensile lattice strain and Sr-doping dramatically modifies the magnetic properties of LSCO thin films, resulting in a NM window around x ¼ 0.2. 12 This result demonstrates the potential for the artificial tuning of the magnetic exchanges in LSCO.…”

IL-1β polymorphism in copd patients in Turkish population

“…While first meta-analysis showed a decreased risk of susceptibility for COPD suggesting that homozygous individuals (CC and TT) had a decreased risk for COPD when compared with heterozygous individuals (CT), the second metaanalysis showed no significant association between IL-1β polymorphisms and COPD (23,24). However, a deeper analysis by ethnicity showed that carriers of T allele of IL-1β -511 and C allele of IL-1β -31 were at a greater risk for developing COPD in East Asians suggesting that genetic variations in the gene sequence may affect the gene expression rate thus causing susceptibility to COPD (24). It is necessary to widen the investigation to cover different populations other than Asians whether this association depends on the population type.…”

Genetic Features of Factors of Inflammation and Fibrosis – Possible Common Pathway of Formation of Predisposition to Atrial Fibrillation and Chronic Obstructive Pulmonary Disease

“…таблицу). Данный полиморфизм наряду с полиморфизмами (-511) и (-31) гена IL-1β, был связан с риском развития ХОБЛ у представителей Восточной Азии [44]. По другим данным, полиморфизм IL-1RN являлся протективным для мужчин и фактором риска для женщин в развитии ХОБЛ [45].…”