Association Between the Growth Hormone Releasing Hormone (<i>GHRH</i>) Gene Polymorphism and Milk Production Traits of Dairy Cattle

Szatkowska, Iwona; Dybus, Andrzej; Grzesiak, Wilhelm; Jedrzejczak, M; Muszyńska, Magdalena

doi:10.1080/09712119.2009.9707044

Cited by 9 publications

(14 citation statements)

References 13 publications

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“…Cows having AA and AB genotypes were reported of producing more fat in their milk. In similar to the previous study, Szatkowska et al (2009) reported for Jersey cattle that the AA cows produced a higher fat composition but a lower milk production compared to those of the AB or BB cows. The results indicatet that genetic polymorphism of a certain fragment of the GHRH|HaeIII gene could be used as MAS for selecting breeding cows for having high genetic ability in producing milk fat and other milk composition.…”

Section: Genotype and Allele Frequencies Of The Ghrh Genesupporting

confidence: 79%

GHRH|HaeIII Gene Polymorphism in Dairy and Beef Cattle at National Livestock Breeding Centers

Rini¹,

Sumantri²,

Anggraini³

2013

Med Pet

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ABSTRACT), kecuali pada sapi FH di BIB Lembang, sapi Brahman, dan Angus di BET Cipelang. Nilai heterozigositas tertinggi adalah 0,471 untuk sapi FH pejantan di BIB Lembang, sebaliknya, nilai terendah adalah 0,344 untuk sapi FH pejantan di BBIB Singosari. Nilai heterozigositas sapi FH lebih rendah daripada sapi Simmental dan Limousin. Gen GHRH pada sapi FH dan sapi pedaging menunjukkan polimorfik, kecuali pada sapi Brahman yang hanya memiliki alel B.

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Section: Genotype and Allele Frequencies Of The Ghrh Genesupporting

confidence: 79%

GHRH|HaeIII Gene Polymorphism in Dairy and Beef Cattle at National Livestock Breeding Centers

Rini¹,

Sumantri²,

Anggraini³

2013

Med Pet

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“…If it does not meet the criteria, the gene is monomorphic (Figures 4 and 5). Genetic diversity in a population can be used as a parameter in studying population genetics and evolution (Szatkowska et al 2009;Konca and Akyuz 2017). In addition, it can also be used to identify and preserve individuals in the population associated with special characters.…”

Section: Gh Dan Ghrh Genes Polymorphismmentioning

confidence: 99%

Body size characteristics and polymorphism in GH and GHRH genes of Simeulue Buffalo of Aceh, Indonesia

Eriani

Rahmi

Jamil³

et al. 2018

Biodiversitas

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Eriani K, Rahmi R, Jamil I, Rosnizar R, Azhar A. 2019. Body size characteristics and polymorphism in GH and GHRH genes of Simeulue Buffalo of Aceh, Indonesia. Biodiversitas 20: 236-242. This study was done to determine body size characteristics, to identify the presence of polymorphism in the GH/MspI and GHRH/HaeIII genes, and to analyze the relationship between GH and GHRH gene polymorphisms to body size characteristics in Simeulue buffalo. Experimental animals used were 45 Simeulue buffalo randomly sampled from three subdistricts, i.e., Salang, Alafan and Simeulue Cut, fifteen from each subdistrict. Body size characteristics measured were withered height, body length, chest circumference, chest depth, and hip height. A 5 mL whole blood was collected from fifteen out of forty five by using EDTA as an anticoagulant. Extraction of genomic DNA and analysis of GH/MspI and GHRH/HaeIII polymorphisms was done using GeneAid DNA extraction kit and polymerase chain reaction-restriction length fragment polymorphism (PCR-RFLP) method, respectively. The data of body size characteristics which includes mean value, standard deviation, and coefficient of variation were analyzed descriptively. The molecular data represented by DNA banding pattern was used to calculate allele and genotype frequencies, expected (He) and observed (Ho) heterozygosities, and Hardy-Weinberg equilibrium. The relationship between genotype and body size characteristic was analyzed using t-test. The results showed that coefficient of variation in body size characteristics was low, ranging from 5.39-16.06% in the age category of 4-6 years old and ranging from 5.25-11.27% in the age category of 2- 4 years old. The results of the molecular analysis indicated that GH/MspI locus was monomorphic by the presence of one (+/+) genotype. GHRH/HaeIII locus was polymorphic as shown by the presence of 3 genotypes namely AA (0.13), AB (0.80) and BB (0.07). Expected heterozygosity (0.80) was higher than observed heterozygosity (0.49). The frequency of GHRH/HaeIII agreed with Hardy Weinberg equilibrium. GHRH/HaeIII polymorphism did not significantly influence (P>0.05) body size characteristics of Simeulue buffalo.

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“…Selection techniques at the DNA level and quantitative trait locus (QTL) can help to accelerate quantitative selections through the identification of major genes controlling the economic traits. Milk yield and its quality in dairy cattle are quantitative traits and controlled by many genes which are potentially influenced by the growth genes (Ahmadi et al, 2015;Ahmadzadeh et al, 2019;Bayram et al, 2017;Szatkowska et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…The growth genes providing GH, GHRH, and Pit1 genes influence biological functions of the livestock, such as growth, development, proliferation of udder cells, and lactogenesis (Ahmadi et al, 2015;Ahmadzadeh et al, 2019;Bayram et al, 2017;Kiyici et al, 2019;Sami et al, 2011;Szatkowska et al, 2009). Bovine Growth Hormone Releasing Hormone (bGHRH) gene consists of five exons and four introns and locates in the chromosome number 13 (BTA-13).…”

Section: Introductionmentioning

confidence: 99%

“…Bovine Growth Hormone Releasing Hormone (bGHRH) gene consists of five exons and four introns and locates in the chromosome number 13 (BTA-13). The GHRH gene affects growth, productivity, milk production, and milk quality in dairy cattle (Szatkowska et al, 2009). The AA cows of the GHRH|HaeIII locus or GHRH g.4474 C>A SNP produced higher milk than the AB (AC) and BB (CC) ones.…”

Section: Introductionmentioning

confidence: 99%

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Association between GH (g.1456_1457insT), GHRH (g.4474 C>A), and Pit-1 (g.244G>A) Polymorphisms and Lactation Traits in Holstein Friesian Cattle

Anggraeni¹,

Sumantri

Saputra³

et al. 2020

Trop. Anim. Sci. J.

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Lactation traits are controlled by many genes, among others, potentially by growth genes. This research was conducted to study genetic polymorphisms of GH, GHRH, and Pit-1 genes and associations of GH (g.1456_1457 InsT), GHRH (g.4474 C>A), and Pit-1 (g.244 G>A) genotypes with milk yield and quality in Holstein Friesian (HF) cattle. Genotyping was conducted for HF dairy cows raised by small farmers from North Lembang (SF-NL) (98 heads) and South Lembang (SF-SL) (95 heads), and also from Cikole Dairy Cattle Station (CDCS) (82 heads) in Lembang, West Java, Indonesia. Progeny tested of HF bulls (17 heads) from LAIC (Lembang Artificial Insemination Center) in West Java and from SAIC (Singosari AIC) (32 heads) in East Java were also genotyped. Effects of genotypes on test day milk yield, fat content, and SNF content were analyzed by General Linear Models. The GHRH g.4474 C>A SNP and Pit-1 g.244 G>A SNP generated high frequencies of C allele to A allele, while the two allelic frequencies of the GH g.1456_1457 InsT varied. Compared to the AA and AC genotypes, the CC genotype of the GH gene resulted higher test day milk yield (p<0.01), fat content (p<0.05), and SNF content (p<0.05). Further the CC genotype of the GHRH gene yielded higher milk yield (p<0.05), while the GG genotype of the Pit-1 gene resulted higher fat content (p<0.05). Therefore the GH g.1456_1457 InsT, GHRH g.4474 C>A SNP, and Pit-1 g.244 G>A SNP are potential to be used as molecular markers for selection on milk yield and quality in domestic HF cattle.

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Association Between the Growth Hormone Releasing Hormone (GHRH) Gene Polymorphism and Milk Production Traits of Dairy Cattle

Abstract: Szatkowska, I., Dybus, A., Grzesiak, W., JFdrzejczak, M. and Muszyliska, M. 2009

Cited by 9 publications

References 13 publications

GHRH|HaeIII Gene Polymorphism in Dairy and Beef Cattle at National Livestock Breeding Centers

GHRH|HaeIII Gene Polymorphism in Dairy and Beef Cattle at National Livestock Breeding Centers

Body size characteristics and polymorphism in GH and GHRH genes of Simeulue Buffalo of Aceh, Indonesia

Association between GH (g.1456_1457insT), GHRH (g.4474 C>A), and Pit-1 (g.244G>A) Polymorphisms and Lactation Traits in Holstein Friesian Cattle

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