Association between sucrase-isomaltase and p53 expression in colorectal cancer

Abstract

SI expression and p53 mutation are associated significantly in CRC. Although the mechanism underlying such an association in presently unknown, the association may define a subset of patients with a worse prognosis.

Prognostic markers in rectal carcinoma

“…Schoeppner et al [48] found that weak expression of in 66 colon cancer patients was associated with a significantly better survival (log rank P= 0.021) than was high expression of galectin-3 within colon carcinomas. However, Lise et al [49] studied 182 Stage I-III colon and rectal carcinoma patients and did not find any association between intratumoral expression of galectin-3 and cancer-specific survival for either colon or rectal primary cancer. The data of Lise et al [49] demonstrate a trend between absence of galectin-3 expression and outcome that does not reach significance.…”

“…However, Lise et al [49] studied 182 Stage I-III colon and rectal carcinoma patients and did not find any association between intratumoral expression of galectin-3 and cancer-specific survival for either colon or rectal primary cancer. The data of Lise et al [49] demonstrate a trend between absence of galectin-3 expression and outcome that does not reach significance. These differences may be due to the smaller number of patients or to an interaction with other variables.…”

“…These differences may be due to the smaller number of patients or to an interaction with other variables. Lise et al [49] concluded that galectin-3 was not a significant prognostic marker for Stage I-III colon or rectal carcinoma but this needs to be assessed further.…”

“…This mucin is composed of variable numbers of tandem repeats of 20 amino acids and expression is often increased in dysplastic polyps [56] as well as in invasive carcinomas. Interestingly, Lise et al [49] found that, like galectin-3 expression, expression of MUC1 mucin by IHC with the monoclonal antibody DF3 trended with an inverse association with outcome but was not a significant covariate for outcome when stage-and grade-related variables were included in the model. These different results with the expression of MUC1, MUC2, and related oligosaccharides suggest that these molecules may be useful but require more evaluation before they can be recommended for use.…”