Association between sleep duration and osteoarthritis and their prevalence in Koreans: A cross-sectional study

Abstract

Objective To determine the association of radiological and symptomatic osteoarthritis with sleep duration in a representative sample of the Korean population. Methods Using data from the national cross-sectional fifth Korea National Health and Nutrition Examination Survey 2010-2012. Of the 16,528 participants in KNHANES-V, 8,918 were adults aged� 50 years who had completed the survey questions on sleep duration and osteoarthritis, and had diagnostic X-ray results. We evaluated the association between sleep duration as the primary predictor for osteoarthritis involving the hip, knee, and spinal joints. A complex sample logistic regression analysis was performed to adjust for the covariates. Results Proportions of participants with total daily sleep duration of �6 hours, 7-8 hours, and �9 hours were 47.1%, 45.2, and 7.7%, respectively. The rate of osteoarthritis diagnoses in the �6 hours, 7-8 hours, and �9 hours of sleep duration groups was 24.1%, 17.6%, and 21.8%, respectively (p <0.0001). The odds ratios (OR) were significantly higher in the �6 hours of sleep group than in the 7-8 hours of sleep group (OR, 1.20; 95% confidence interval [CI], 1.03-1.39; p = 0.02), but no significant difference in the �9 hours of sleep group was found after adjusting the confounding variables. When we compared knee joint pain (Numeric Rating Scale 0 versus 1-10) in participants with grade 2-4 Kellgren-Lawrence (KL) classification after adjusting these same confounding variables, the �6 hours of sleep group (OR, 1.32; 95% CI, 1.10-1.58) and the �9 hours of sleep group (OR, 1.41; 95% CI, 1.03-1.95) showed significantly higher ORs.

Association between sleep disorders and osteoarthritis: A case–control study of 351,932 adults in the UK

“…One cross‐sectional study of 11,540 individuals from South Korea found that sleeping ≤ 5 hr per night was associated to a significant extent with higher odds of developing osteoarthritis (men: OR = 1.38–2.28; women: OR = 1.26–1.63; Jung et al., 2018). Another study including 8,918 adults living in the same country revealed that there was a cross‐sectional association between getting ≤ 6 hr of sleep per night and developing osteoarthritis (OR = 1.20, 95% CI = 1.03–1.39; comparison group: 7–8 hr of sleep per night; Cho et al., 2020). The present study not only corroborates these findings in the UK, but also shows that the relationship between sleep disorders and osteoarthritis is significant in all sex and age groups, except in that of patients aged > 80 years.…”

“…A significant body of research has focused on the association between osteoarthritis and sleep disorders in recent years (Cho et al., 2020; Fertelli & Tuncay, 2019; Fu et al., 2019; Jeong, Kim, & Park, 2019; Jung et al., 2018; Koyanagi et al., 2014; Martinez, Reddy, Mulligan, Hynan, & Wells, 2019; Taylor et al., 2018; Wilcox et al., 2000). For example, a study in the USA including 300 veterans with hip or knee osteoarthritis found that the prevalence of insomnia‐related symptoms was about 53% in the sample (Taylor et al., 2018).…”

“…The deleterious effects of osteoarthritis on sleep are likely mediated by pain and poor levels of well‐being. Interestingly, two studies have also suggested that sleep disorders may increase the occurrence of osteoarthritis (Cho et al., 2020; Jung et al., 2018). This association may be due to obesity (Itani, Kaneita, Murata, Yokoyama, & Ohida, 2011; Reyes et al., 2016), hypertension (Guo et al., 2013; Zhang, Wang, & Liu, 2017), diabetes (Gangwisch et al., 2007; Louati, Vidal, Berenbaum, & Sellam, 2015) or psychiatric disorders (Freeman, Sheaves, Waite, Harvey, & Harrison, 2020; Huang et al., 2016).…”

The multimorbidity of hypertension and osteoarthritis and relation with sleep quality and hyperlipemia/hyperglycemia in China’s rural population

“…Adding to the confusion, more sleep disorders, shorter sleep duration, and poorer sleep quality are likely to the complaint of OA, and have been demonstrated to be a risk of HTN. For example, hypertension risk might be increased by sleep disorders, especially sleep deprivation 15 and inappropriate sleep duration 16 , while some studies suggested that sleep disturbance might increase the occurrence of OA 17 , 18 , as does the finding might be associated with HTN 19 . On the contrary, another study pointed that the presence of chronic OA has the potential to increase the risk for incurring sleep disturbances 20 .…”

Relationship Between Sleep and Arthritis in a Middle-aged and Older Chinese Population- the China Health and Retirement Longitudinal Study

“…At present, there are few studies on the relationship between sleep and arthritis. For Asian population, previous studies in Korea only focused on sleep duration and arthritis, ignoring the impact of sleep quality [26][27][28][29]. A recent study of the Chinese population only selected the rural elderly with RA in single center, could not represent the prevalence of arthritis in middle-aged and older Chinese [30].The CHARLS is a national survey of middle-aged and elderly people.…”