Association between short-term air pollution exposure and attention-deficit/hyperactivity disorder-related hospital admissions among adolescents: A nationwide time-series study

Park, Jiyoon; Sohn, Ji Hoon; Cho, Sung‐Joon; Seo, Hwa Yeon; Hwang, Il-Ung; Hong, Yun Chul; Kim, Kyoung Nam

doi:10.1016/j.envpol.2020.115369

Cited by 13 publications

(12 citation statements)

References 29 publications

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“…Another study reported an association between short-term exposure to SO 2 and ADHD-related hospital admission in adolescents aged 10-19 years [13].…”

Section: Discussionmentioning

confidence: 98%

“…Previous studies have reported an association between children's behavioral development and prenatal exposure to sulfur dioxide (SO 2 ) [9,10], one of the major gaseous pollutants derived from coal-red power plants, smelters, and industrial emissions [11]. Although the relation between SO 2 exposure and ADHD has not been well investigated, SO 2 has been associated with various neurodevelopmental de cits, such as ne motor skills, executive function, and ADHD-related hospital admissions [12,13].…”

Section: Introductionmentioning

confidence: 99%

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DNA methylation at insulin-insulin like growth factor 2 is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms

Choi

Cho

Hong

et al. 2022

Preprint

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Backgrounds: Epigenetic influence plays a role in the association between exposure to air pollution and attention deficit hyperactivity disorder (ADHD); however, research regarding sulfur dioxide (SO2) is scarce. Herein, we investigate the associations between prenatal SO2 exposure and ADHD rating scale (ARS) scores at ages 4, 6, and 8 years repeatedly in a mother-child cohort (n = 329). Whole blood samples were obtained at ages 2 and 6 years, and genome-wide DNA methylation (DNAm) was analyzed for 51 children using the Illumina Infinium HumanMethylation BeadChip. We analyzed the associations between prenatal SO2 exposure and DNAm levels at ages 2 and 6, and investigated the association between the DNAm levels at the significant CpGs and ARS at ages 4, 6, and 8. Weighted gene co-methylation network analysis was conducted to detect modules weighted for prenatal SO2 exposure and ARS.Results: Prenatal SO2 exposure was associated with ADHD symptoms. DNAm levels at the 6 CpGs (cg07583420 (INS-IGF2), cg05075097 (INS-IGF2), cg25163476 (INS-IGF2), cg20296524 (TARBP1), cg15705054 (PBXIP1), and cg05951817 (SLC6A4)) at age 2 were associated with prenatal SO2 exposure levels; however, DNAm at age 6 was not associated with prenatal SO2 exposure. Of the 6 CpGs, 5 were grouped into a module correlated with prenatal SO2 exposure and ARS, of which cg07583420 (INS-IGF2) was persistently linked with ARS at ages 4, 6, and 8. Conclusions: Changes in DNAm levels associated with prenatal SO2 exposure during early childhood are linked to increases in ARS in later childhood.

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“…Another study reported an association between short-term exposure to SO 2 and ADHD-related hospital admission in adolescents aged 10-19 years [13].…”

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

DNA methylation at insulin-insulin like growth factor 2 is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms

Choi

Cho

Hong

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

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“…43 Fourth, there is a concern of exposure misclassification attributable to large spatial units, although several time-series studies Open access conducted in Korea used regional air pollution levels as exposures (instead of air pollution levels measured for a finer spatial unit). [44][45][46] This type of error (ie, Berkson error) is likely to lead to imprecision in the estimation of associations rather than bias. Fifth, we only considered three criteria air pollutants (ie, PM 2.5 , NO 2 and O 3 ) as exposures according to previous studies.…”

Section: Discussionmentioning

confidence: 99%

Effects of short-term exposure to air pollution on hospital admissions for autism spectrum disorder in Korean school-aged children: a nationwide time-series study

et al. 2022

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ObjectivesThis study explored the effects of short-term exposure to air pollution on hospital admissions for autism spectrum disorder (ASD), a proxy for symptom aggravation, among Korean children aged 5–14 years.DesignTime-series study.Setting, participants and outcome measuresWe used data from the National Health Insurance Service (2011–2015). Daily concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2) and ozone (O3) levels in each region were used as exposures. ASD cases were defined based on a principal admission diagnosis of the claims data. We applied distributed lag non-linear models and a generalised difference-in-differences method to the quasi-Poisson models to estimate the causal effects of air pollution for up to 6 days. We also performed weighted quantile sum regression analyses to assess the combined effects of air pollution mixtures.ResultsPM2.5 levels at lag day 1, NO2 levels at lag day 5 and O3 levels at lag day 4 increased the risks of hospital admissions for ASD (relative risk (RR)=1.17, 95% CI 1.10 to 1.25 for PM2.5; RR=1.09, 95% CI 1.01 to 1.18 for NO2 and RR=1.03, 95% CI 1.00 to 1.06 for O3). The mean daily count of hospital admissions for ASD was 8.5, and it would be 7.3, 7.8 and 8.3 when the PM2.5 levels would be decreased by 10.0 µg/m3, NO2 by 10 ppb and O3 by 10 ppb, respectively. The weighted quantile sum index, constructed from PM2.5, NO2 and O3 levels, was associated with a higher risk of hospital admissions for ASD (RR 1.29, 95% CI 1.14 to 1.46), where NO2 was found to contribute to the effects most (the weight of 0.80).ConclusionsThese results emphasise that reduction of air pollution exposure should be considered for ASD symptom management, with important implications for the quality of life and economic costs.

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“…In recent years, systematic research into the health issues caused by air pollution has been directly focused on the effects of firework-related pollutants [ 11 , 12 ]. Findings from studies on mental disorders have also revealed that short-term air pollution exposure is associated with an increased risk of hospitalizations related to attention-deficit/hyperactivity disorder (ADHD) [ 54 ], depression [ 54 ], schizophrenia, and epileptic seizures and/or hospitalizations [ 55 , 56 , 57 , 58 , 59 ]. Further, early research suggests that short term exposure to high air pollution concentrations could play a role in COVID-19 outcomes and exacerbations [ 60 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of 4th of July Fireworks on Spatiotemporal PM2.5 Concentrations in California Based on the PurpleAir Sensor Network: Implications for Policy and Environmental Justice

Mousavi

Yuan

Masri

et al. 2021

IJERPH

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Fireworks are often used in celebration, causing short term, extremely high particulate matter air pollution. In recent years, the rapid development and expansion of low-cost air quality sensors by companies such as PurpleAir has enabled an understanding of air pollution at a much higher spatiotemporal resolution compared to traditional monitoring networks. In this study, real-time PM2.5 measurements from 751 PurpleAir sensors operating from June to July in 2019 and 2020 were used to examine the impact of 4th of July fireworks on hourly and daily PM2.5 concentrations at the census tract and county levels in California. American Community Survey (ACS) and CalEnviroScreen 3.0 data were used to identify correlations between PM2.5 measurements and socioeconomic status (SES). A two-step method was implemented to assure the quality of raw PM2.5 sensor data and sensor calibration against co-located reference instruments. The results showed that over 67% and 81% of counties experienced immediate impacts related to fireworks in 2019 and 2020, respectively. Relative to 2019, the peak PM2.5 concentrations on July 4th and 5th 2020 were, on average, over 50% higher in California, likely due to the COVID-19-related increase in the use of household-level fireworks. This increase was most pronounced in southern counties, which tend to have less strict firework-related regulations and a greater use of illegal fireworks. Los Angeles County experienced the highest July 4th daily PM2.5 levels both in 2019 (29.9 µg·m−3) and 2020 (42.6 µg·m−3). Spatial hot spot analyses generally showed these southern counties (e.g., Los Angeles County) to be regional air pollution hotspots, whereas the opposite pattern was seen in the north (e.g., San Francisco). The results also showed PM2.5 peaks that were over two-times higher among communities with lower SES, higher minority group populations, and higher asthma rates. Our findings highlight the important role that policy and enforcement can play in reducing firework-related air pollution and protecting public health, as exemplified by southern California, where policy was more relaxed and air pollution was higher (especially in 2020 when the 4th of July coincided with the COVID-19-lockdown period), and in disadvantaged communities where disparities were greatest.

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Association between short-term air pollution exposure and attention-deficit/hyperactivity disorder-related hospital admissions among adolescents: A nationwide time-series study

Cited by 13 publications

References 29 publications

DNA methylation at insulin-insulin like growth factor 2 is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms

DNA methylation at insulin-insulin like growth factor 2 is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms

Effects of short-term exposure to air pollution on hospital admissions for autism spectrum disorder in Korean school-aged children: a nationwide time-series study

Impact of 4th of July Fireworks on Spatiotemporal PM2.5 Concentrations in California Based on the PurpleAir Sensor Network: Implications for Policy and Environmental Justice

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