Association between serum S100A1 level and Global Registry of Acute Coronary Events score in patients with non-ST-segment elevation acute coronary syndrome

Li, Yuanmin; Han, Chenjun; Zhang, Peng; Zang, Wangfu; Guo, Rong

doi:10.1177/0300060518769524

Cited by 8 publications

(13 citation statements)

References 22 publications

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“…Based on previous work, 14 we retrospectively reviewed patients with AAD to examine the value of S100A1 in diagnosing AAD. The results suggested that the plasma concentration of S100A1 was significantly increased in patients with AAD and showed potential diagnostic value for AAD.…”

Section: Discussionmentioning

confidence: 99%

“… 13 S100A1 can serve as an early diagnostic marker of ischemic coronary artery disease in patients with acute myocardial infarction. 14 However, few studies have evaluated S100A1 as a biomarker in patients with AAD. Therefore, in this study, an elevated S100A1 level was used as a marker of AAD to explore its diagnostic value in patients with AAD.…”

Section: Introductionmentioning

confidence: 99%

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S100A1 as a potential biomarker for the diagnosis of patients with acute aortic dissection

Han

Liu

et al. 2021

J Int Med Res

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Objective Acute aortic dissection (AAD) is a common life-threatening cardiovascular disease. This retrospective study was conducted to analyze the plasma concentration of S100A1 and its diagnostic value for AAD through receiver operating characteristic (ROC) curve and logistic regression analyses. Methods Seventy-eight patients with AAD and 77 healthy controls were included, and the relevant clinical data for each group were collected. According to the Stanford classification, the AAD patients were divided into types A and B. The plasma levels of S100A1, D-dimer, hypersensitive C-reactive protein, and cardiac troponin T were detected by enzyme-linked immunosorbent assays. Results The S100A1 concentrations in the healthy control, Stanford A, and Stanford B groups were 0.7 ± 0.6, 4.9 ± 2.6, and 3.5 ± 2.2 ng/mL, respectively. The concentration of S100A1 was increased in patients with AAD complicated with aortic regurgitation, pericardial effusion, or in-hospital death. ROC curve analysis showed that the area under the curve was 0.89. Logistic regression analysis revealed that the S100A1 level was an important risk factor for the development of AAD. Conclusion Plasma S100A1 is significantly elevated in patients with AAD, and its concentration has potential clinical value for diagnosing AAD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

S100A1 as a potential biomarker for the diagnosis of patients with acute aortic dissection

Han

Liu

et al. 2021

J Int Med Res

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“…The studies of Stamatelopoulos et al on amyloid-β (1-40) and Li et al on serum S100A1 found that these biomarkers may help the prognosis in clinical risk scoring, such as GRACE and TIMI, which are defined as mortality predictors in ACS guidelines [7][8]. In the present study, Netrin-1 levels measured at the time of presentation to the hospital were found to be significantly different in the medium and high-risk GRACE groups as compared with the low-risk group (p = 0.017).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, various markers are evaluated to demonstrate the success of reperfusion and reduced ischemia [5][6]. It has been shown that clinical risk scores, such as Global Registry of Acute Coronary Events (GRACE) and Thrombolysis in Myocardial Ischemia (TIMI), which have significant distinguishing power in calculating the hospital mortality risks, hospital discharge, and six-month mortality risks mentioned in ACS guidelines, can be improved with some biomarkers and new parameters [7][8].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Serum Netrin-1 Levels on Diagnosis and Prognosis in Patients Admitted to the Emergency Service for Acute Coronary Syndrome

Mutlu

Akıllı

Cander

et al. 2020

Cureus

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Background Netrin-1 is a recently discovered diagnostic biomarker that indicates atherosclerosis, angiogenesis, and ischemia-reperfusion damage. There are no human studies about Netrin-1 in acute coronary syndrome (ACS). The purpose of the present study was to investigate Netrin-1 levels in the early diagnosis and successful reperfusion of ACS. Method The study was conducted with 188 patients diagnosed with ACS and 50 healthy subjects at the emergency unit in a prospective design. Blood samples were collected from the patient group at initial admission and after angiography. The control group consisted of healthy adult subjects without any disease. Netrin-1 levels were studied in both groups. Results The Netrin-1 levels of the patient group at the time of admission were found to be higher than of the control group (p<0.001). In the patient group, netrin-1 levels measured at initial admission (1.53±0.19) and after angiography (1.49±0.19) were determined to be statistically significant (p:0.049). In the patient group, where the Thrombolysis in Myocardial Infarction (TIMI) 3 flow was established after angiography, netrin-1 levels were detected to be low (p:0.039). Netrin-1 levels obtained at the time of admission were determined to be significantly different in the Global Registry of Acute Coronary Events (GRACE) moderate and high-risk groups in comparison to the low-risk group (p:0.017). Conclusion Netrin-1 was shown to increase in the early diagnosis of ACS and to decrease in patients for whom reperfusion was established after angiography. Therefore, Netrin-1 can be an important biomarker as an indicator of diagnosis and successful reperfusion in ACS.

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S100A1 is a sensitive and specific cardiac biomarker for early diagnosis and prognostic assessment of acute myocardial infarction measured by chemiluminescent immunoassay

Wang

Sun

et al. 2021

Clinica Chimica Acta

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Association between serum S100A1 level and Global Registry of Acute Coronary Events score in patients with non-ST-segment elevation acute coronary syndrome

Cited by 8 publications

References 22 publications

S100A1 as a potential biomarker for the diagnosis of patients with acute aortic dissection

S100A1 as a potential biomarker for the diagnosis of patients with acute aortic dissection

Effect of Serum Netrin-1 Levels on Diagnosis and Prognosis in Patients Admitted to the Emergency Service for Acute Coronary Syndrome

S100A1 is a sensitive and specific cardiac biomarker for early diagnosis and prognostic assessment of acute myocardial infarction measured by chemiluminescent immunoassay

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