Association Between Serum Complement C3 Levels and Age-Related Cataract

Shao, Mingxi; Li, Danhui; Teng, Jisen; Zhang, Yudong; Li, Shengjie; Cao, Wenjun

doi:10.1167/iovs.17-22522

Cited by 4 publications

(3 citation statements)

References 29 publications

(33 reference statements)

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“…As the promoter of the classical complement cascade, C1q is the key modulation node of this pathway. Some studies have shown that the amount of complement C3 in the peripheral blood of sick patients with congenital cataracts is dramatically decreased, and the reduction of complement C3 is a risk factor for congenital cataracts (Shi et al 2003 ; Ge et al 2014 ; Shao et al 2017 ; Li et al 2017 ). In addition, complement deposition was also observed in the lens of mice with inflammatory damage (Montalvo et al 2007 ).…”

Section: Discussionmentioning

confidence: 99%

Integrative Bioinformatics Analysis of mRNA Expression Profiles of Mice to Explore the Key Genes Involved in Crim1 Mutation-Induced Congenital Cataracts

et al. 2022

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Crim1 has been implicated in cataracts in mice and is of great importance in the development of the eye in both humans and mice. Therefore, we aimed to clarify how Crim1 mutations affect lens development and the molecular mechanism of cataracts in mice through comprehensive bioinformatics analysis. The microarray chip was downloaded from the GEO database to obtain the gene expression profile data set. Differentially expressed genes (DEGs) were screened using the limma package. GO and KEGG analyses of DEGs were performed using the DAVID database. Then, we established the protein–protein interaction (PPI) network in Cytoscape. Next, we used MCODE to analyze the data. We obtained 750 DEGs in total, including 407 upregulated DEGs and 343 downregulated DEGs. GO analysis showed that the DEGs were mainly related to biological processes, such as apoptosis, cell translation and the immune system. KEGG analysis showed that the enriched functions and pathways were related to the processing and presentation of ribosomes, lysosomes, and antigens. We identified 18 HUB genes, among which four core genes, C1qa, C1qb, C1qc, and Cd74, were closely related to congenital cataracts induced by Crim1 mutation. This study reveals the molecular pathogenesis of congenital cataracts induced by Crim1, and this information is expected to facilitate clinical genetic testing, molecular diagnosis, prognosis, and individualized chemotherapy for congenital cataracts (CC).

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Section: Discussionmentioning

confidence: 99%

Integrative Bioinformatics Analysis of mRNA Expression Profiles of Mice to Explore the Key Genes Involved in Crim1 Mutation-Induced Congenital Cataracts

et al. 2022

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“…If both eyes suffered from ARC, only one eye was randomly selected for the study. The final sample consisted of 219 ARC patients who met the following inclusion criteria as described previously 13 : age ≥45 years; ARC recorded using the Lens Opacities Classification System III; ARC defined as the presence of any type of ARC (cortical, nuclear or PSC) or a history of cataract surgery (pseudophakic or aphakic eyes) in either eye; no history of secondary cataracts, congenital cataracts or any other eye diseases and no history of systemic diseases such as acute infectious diseases, kidney disease, autoimmune disease and cancer.…”

Section: Methodsmentioning

confidence: 99%

“…Of these, 32 normal subjects (cataract=5, cancer=2, renal disease=6, liver disease=4, autoimmune disease=2, macular degeneration=3, cardiovascular disease=4, other diseases=6) were later excluded from the study based on the inclusion criteria. The final sample consisted of 218 control subjects who met the following previously described criteria 13 : age ≥45 years; no history of any types of cataracts, secondary cataracts, congenital cataracts and any other eye diseases and no history of systemic diseases such as acute infectious diseases, kidney disease, autoimmune disease and cancer.…”

Section: Methodsmentioning

confidence: 99%

Association between serum lipids concentration and patients with age-related cataract in China: a cross-sectional, case–control study

Zhang

et al. 2018

BMJ Open

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ObjectiveObesity and a high-fat diet have been found to be associated with an increased risk of age-related cataract (ARC). Thus, this study aimed to investigate whether serum lipid levels are associated with the incidence of ARC.DesignCross-sectional, case–control study.SettingEyeandENT Hospital of Fudan University, Shanghai, China.ParticipantsA total of 219 ARC (male=94, female=125) subjects and 218 (male=110, female=118) normal control subjects were recruited in this study.Outcome measuresA detailed eye and systematic examination was performed. Serum high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) and cholesterol (CHO) levels were measured by enzymatic colorimetry, and serum apolipoprotein A (APOA) and apoB (APOB) levels were measured by immunoturbidimetry. The subgroups were classified according to gender and types of disease (cortical, nuclear and posterior subcapsular cataract). Logistic regression analyses were performed to identify the association between serum lipid levels and ARC.ResultsThe serum LDL-C, TG, CHO and APOA levels were significantly higher (p<0.05) in the ARC group than in the control group. A similar result was observed when the serum lipid concentrations were compared between the ARC and control groups both in male and female subgroups. A higher proportion of individuals in the ARC group had higher LDL-C, TG, CHO and APOA levels (fold=3.45, 17.37, 3.27 and11.91, respectively; p<0.0001 in all cases) than in the control group. Results of the logistic regression analyses revealed that high LDL-C (ORs=1.897, 95% CI 0.960 to 3.678) and TG (OR=1.854, 95% CI 1.232 to 2.791) were the independent risk factors for ARC.ConclusionThe serum LDL-C and TG levels were demonstrated to be independent risk factors for ARC.

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The inflammatory potential of diet is associated with the risk of age-related eye diseases

Vergroesen,

Thee,

de Crom

et al. 2023

Clinical Nutrition

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Association Between Serum Complement C3 Levels and Age-Related Cataract

Abstract: ARC patients have lower serum C3 levels, which were further demonstrated to be correlated with the onset/development of ARC. These findings suggest the involvement of C3 in the pathomechanisms of ARC.

Cited by 4 publications

References 29 publications

Integrative Bioinformatics Analysis of mRNA Expression Profiles of Mice to Explore the Key Genes Involved in Crim1 Mutation-Induced Congenital Cataracts

Integrative Bioinformatics Analysis of mRNA Expression Profiles of Mice to Explore the Key Genes Involved in Crim1 Mutation-Induced Congenital Cataracts

Association between serum lipids concentration and patients with age-related cataract in China: a cross-sectional, case–control study

The inflammatory potential of diet is associated with the risk of age-related eye diseases

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