The inflammatory potential of diet is associated with the risk of age-related eye diseases

Vergroesen, Joëlle E.; Thee, Eric F.; de Crom, Tosca O.E.; Kiefte-de Jong, Jessica C.; Meester-Smoor, Magda A.; Voortman, Trudy; Klaver, Caroline C.W.; Ramdas, Wishal D.

doi:10.1016/j.clnu.2023.10.008

Cited by 7 publications

(7 citation statements)

References 61 publications

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“…The causal effect of each analysis method is indicated by the slope of the line. promoting the onset of these blinding eye diseases (Vergroesen et al, 2023). In summary, inflammatory factors play a pivotal role in the development of these three blinding eye diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated levels of inflammatory cytokines have been observed in the eyes of patients with these conditions ( Ten Berge et al, 2019 ). Moreover, another study highlighted the potential influence of a pro-inflammatory diet in promoting the onset of these blinding eye diseases ( Vergroesen et al, 2023 ). In summary, inflammatory factors play a pivotal role in the development of these three blinding eye diseases.…”

Section: Discussionmentioning

confidence: 99%

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Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis

Teng,

Wang,

et al. 2024

Front. Aging Neurosci.

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BackgroundPrevious studies have explored the associations between circulating inflammatory cytokines and blinding eye diseases, including glaucoma, cataract and macular degeneration. However, the causality of these associations remains controversial. This study employs a bidirectional Mendelian randomization (MR) study to investigate the causal relationships between 41 circulating inflammatory cytokines and these blinding eye diseases.MethodsSummary data for glaucoma, cataract, macular degeneration and 41 circulating inflammatory cytokines were publicly available. The inverse variance weighted (IVW) method was employed as the main analysis method. Additionally, various sensitivity tests, including MR–Egger regression, weighted median, weight mode, Cochran’s Q test, MR pleiotropy Residual Sum and Outlier test, and leave-one-out test, were conducted to evaluate sensitivity and stability of results.ResultsThe IVW analysis identified six circulating inflammatory cytokines causally associated with the risk of blinding eye diseases: Monokine induced by interferon-gamma (MIG) for glaucoma, interleukin-1 receptor antagonist (IL-1ra), IL-6, IL-10, and platelet derived growth factor BB (PDGFbb) for cataract, and MIG and hepatocyte growth factor (HGF) for macular degeneration. However, it is noteworthy that none of these associations remained significant after Bonferroni correction (p < 0.0004). Reverse MR analyses indicated that cataract may lead to a decrease in vascular endothelial growth factor (VEGF) levels (OR: 3.326 × 10−04, 95% CI: 5.198 × 10−07 − 2.129 × 10−01, p = 0.0151).ConclusionThis study highlights the potential roles of specific inflammatory cytokines in the development of glaucoma, cataract and macular degeneration. Moreover, it suggests that VEGF is likely to be involved in cataract development downstream. These findings offer insights for early prevention and novel therapeutic strategies for these blinding eye diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis

Teng,

Wang,

et al. 2024

Front. Aging Neurosci.

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“…Therefore, SII and NLR have a better value than PLR and LMR for assessing RA disease activities, which has been proved by another study ( 30 ). Furthermore, higher DII and blood inflammation indicators have been shown to synergistically increase the risk of developing cognitive impairment ( 33 ) and cataracts ( 34 ). We demonstrated a strong association between pro-inflammatory diet and SII/NLR in patients with RA, which was not relatively reliable in PLR and LMR.…”

Section: Discussionmentioning

confidence: 99%

Association of dietary inflammatory index with immune-inflammatory biomarkers in rheumatoid arthritis patients: results from NHANES 1999–2018

Lu,

Xie,

Shen

et al. 2024

Front. Nutr.

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BackgroundSynovial inflammation is the main reason for joint damage in patients with rheumatoid arthritis (RA). Diet is recognized as one of the therapeutic strategies to control the inflammatory activity in RA. However, few studies have investigated the association between diet and immune-inflammatory biomarkers in RA patients. Our study aims to examine the correlation between dietary inflammatory potential and systemic immune-inflammation Index (SII), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR) in the RA population.Materials and methodsThe National Health and Nutrition Examination Survey (NHANES) was the data source utilized in this study, spanning from 1999 to 2018. The study encompassed 2,500 RA participants in total. The dietary inflammatory potential was calculated by the dietary inflammation index (DII) score based on dietary recall interviews. The generalized multiple linear regression analyses were used to evaluate the relationship between DII and immune-inflammatory markers. Furthermore, subgroup analyses and restricted cubic spline models were performed.ResultsAfter full adjustments, there were significant positive correlations between DII levels and SII/NLR in RA patients (SII, β: 14.82, 95% CI: 5.14–24.50, p = 0.003; NLR, β: 0.04, 95% CI: 0.01–0.08, p = 0.005). It was noteworthy that inconsistent results were observed in the association between DII and SII as well as NLR in subgroups of red blood cell levels (Interaction p-value <0.001).ConclusionPro-inflammatory dietary status in the RA population is significantly positively correlated with SII and NLR, influenced by variations in red blood cell levels.

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“…Recently, it was reported that senolytic drugs have anti-inflammatory effects in zebrafish models of chronic skin inflammation and in a high-cholesterol diet [174][175][176][177][178][179]. Taken together, these characteristics suggest that rag mutant zebrafish offer a valuable platform for investigating and seeking treatments for senescence in vivo, as well as for the aging process induced by chronic inflammation (Figure 3).…”

Section: Senescencementioning

confidence: 96%

Inflammation in Development and Aging: Insights from the Zebrafish Model

Mastrogiovanni,

Martínez-Navarro,

Bowman

et al. 2024

IJMS

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Zebrafish are an emergent animal model to study human diseases due to their significant genetic similarity to humans, swift development, and genetic manipulability. Their utility extends to the exploration of the involvement of inflammation in host defense, immune responses, and tissue regeneration. Additionally, the zebrafish model system facilitates prompt screening of chemical compounds that affect inflammation. This study explored the diverse roles of inflammatory pathways in zebrafish development and aging. Serving as a crucial model, zebrafish provides insights into the intricate interplay of inflammation in both developmental and aging contexts. The evidence presented suggests that the same inflammatory signaling pathways often play instructive or beneficial roles during embryogenesis and are associated with malignancies in adults.

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The inflammatory potential of diet is associated with the risk of age-related eye diseases

Cited by 7 publications

References 61 publications

Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis

Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis

Association of dietary inflammatory index with immune-inflammatory biomarkers in rheumatoid arthritis patients: results from NHANES 1999–2018

Inflammation in Development and Aging: Insights from the Zebrafish Model

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