Association between retinal microvasculature and optic disc alterations in high myopia

He, Jiangnan; Chen, Qiuying; Yao, Yin; Zhou, Hongfeng; Fan, Ying; Zhu, Jianfeng; Zou, Haidong; Xu, Xun

doi:10.1038/s41433-019-0438-7

Cited by 59 publications

(74 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean area of the superficial FAZ (mm 2 ) and the area of deep FAZ (mm 2 ) were 0.31 ± 0.09 and 0.43 ± 0.12 in the high myopia group and 0.25 ± 0.05 and 0.34 ± 0.07 in the control group, respectively. He et al [21] also showed that the area of the FAZ in the superficial layer was larger in highly myopic eyes. The mean area of the FAZ (mm 2 ) was 0.39 ± 0.13 in the high myopia group and 0.35 ± 0.10 in the control group.…”

Section: Discussionmentioning

confidence: 92%

Repeatability of Manual Measurement of Foveal Avascular Zone Area in Optical Coherence Tomography Angiography Images in High Myopia

Lee

Baek

et al. 2020

Korean J Ophthalmol

View full text Add to dashboard Cite

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses /by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 113 Original ArticleHigh myopia is one of the most common causes of visual loss and is especially common in Asia. The prevalence of myopia is as high as 80% in Asia and 25% in other regions [1][2][3]. Severe myopia can increase the risk of glaucoma, retinal detachment, chorioretinal atrophy, and lacquer cracks. Therefore, high myopia patients, even those without other ophthalmic diseases, should not be overlooked [4]. In myopia, the sclera and chorioretina are enlarged to reduce the thickness of the macular choroid, which may result in delayed choroidal circulation to induce an ischemic state of Purpose: To analyze the repeatability of manual measurement of foveal avascular zone (FAZ) area in an optical coherence tomography angiography (OCTA) image in high myopia. Methods: This study comprised patients with high myopia and controls. Two consecutive FAZ areas of the superficial and deep capillary plexus were obtained using OCTA. The intraclass correlation coefficient (ICC) and coefficient of variation (CV) were assessed, and univariate and multivariate generalized linear mixed models were conducted to identify factors related to repeatability. Results: Thirty eyes with high myopia and 34 eyes of healthy subjects were included in the study. The mean age in high myopia and control subjects was 55.5 and 60.8 years, respectively, the mean spherical equivalent was -9.98 and -0.55 diopters, and the mean axial length was 28.0 and 23.9 mm. The ICCs of FAZ area of the superficial capillary plexus (SCP) were 0.891 and 0.919, while the CVs were 8.8% and 8.5%. In measurement of the deep capillary plexus, the ICCs were 0.788 and 0.907, while the CVs were 11.2% and 11.0%, which were acceptable but exhibited lower repeatability than those of SCP. Multivariate analyses showed that older age (p = 0.030) and greater axial length (p = 0.005) were significantly associated with lower repeatability of SCP FAZ area measurements. In addition, greater axial length (p = 0.044) was a significant factor for lower repeatability of deep capillary plexus FAZ area measurements. Conclusions: Manual measurement of FAZ area using OCTA exhibited relatively good repeatability for high myopia. Age and axial length affected repeatability and should be considered when analyzing FAZ areas in high myopia patients.

show abstract

Section: Discussionmentioning

confidence: 92%

Repeatability of Manual Measurement of Foveal Avascular Zone Area in Optical Coherence Tomography Angiography Images in High Myopia

Lee

Baek

et al. 2020

Korean J Ophthalmol

View full text Add to dashboard Cite

show abstract

“…Cheng et al 20 observed that a decreasing perifoveal VD in DCP was associated with high myopia. He et al 40 reported a significant correlation of AL with parafoveal VD in DCP, but not in the SCP. Ye et al 19 also indicated that decreased VD in DCP correlated with outer retinal layer thinning in eyes with high myopia.…”

Section: Discussionmentioning

confidence: 95%

Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study

Lin

Gao

et al. 2021

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE.To characterize longitudinal changes in macular microvasculature as quantified from optical coherence tomography angiography (OCTA) metrics in primary open-angle glaucoma (POAG) eyes with and without high myopia. METHODS.In total, 63 and 61 POAG eyes with and without high myopia, respectively, underwent swept-source OCTA imaging in at least four follow-up visits at an ophthalmic center, with a scanning protocol of 3-× 3-mm centered at the fovea. The foveal avascular zone (FAZ) area, FAZ circularity, and vessel density (VD) in both the superficial (SCP) and deep capillary plexuses (DCP) were measured. The rate of change in macular OCTA metrics over time was estimated using linear mixed-effects models in both groups of POAG eyes.RESULTS. The mean follow-up time and number of visits were 27.72 ± 8.57 months and 8.5 (8 to 13) times, and 30.95 ± 10.19 months and 10 (8-13) times in POAG eyes with and without high myopia, respectively. VD in the DCP reduced significantly more quickly in POAG eyes with high myopia than in those without high myopia (−5.14%/year vs. −3.71%/year, P = 0.008). Moreover, lower baseline VD in the DCP was significantly associated with faster VD reduction in POAG with high myopia eyes (P < 0.001). Conversely, the VD reduction rate in the SCP, FAZ area, and FAZ circularity in both the SCP and DCP were similar in both groups (all Ps > 0.05). CONCLUSIONS.VD in DCP reduced significantly more quickly in POAG eyes with high myopia over time. Density in the DCP reduced more quickly when baseline VD was low.

show abstract

“…The protocol for this cross-sectional study was consistent with those of previous studies. 15,27 The systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the students were measured. The mean arterial pressure (MAP) was calculated using the following formula: (SBP + 2 × DBP)/3.…”

Section: Methodsmentioning

confidence: 99%

Morphological Characteristics of the Optic Nerve Head and Choroidal Thickness in High Myopia

et al. 2020

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

This study aimed to explore the morphological characteristics of Bruch's membrane opening distance (BMOD), border length (BL), border tissue angle (BTA), vertical tilt angle, and peripapillary atrophy (PPA), as well as their associations with choroidal thickness (ChT) in young healthy highly myopic eyes. METHODS. A total of 167 patients with high myopia and 172 individuals without high myopia were enrolled. All of the subjects were divided by axial length. The PPA area was measured on fundus photographs. BMOD, BL, BTA, vertical tilt angle, macular ChT (mChT), and peripapillary ChT (pChT) were measured on swept-source optical coherence tomography scans. RESULTS. The PPA area (P < 0.0001) and vertical tilt angle (P < 0.0001) were larger, BMOD (P < 0.0001) and BL (P < 0.0001) were longer, and BTA (P < 0.0001) was smaller in the high-myopia group compared with the group without high myopia. Every 1-μm increase in BMOD was associated with a 35.80-μm decrease in mChT; every 1°decrease in BTA was correlated with a 0.32-μm decrease in mChT and a 0.26-μm decrease in pChT; and no association was found between PPA area and ChT in the multivariate linear regression model. CONCLUSIONS. PPA area, BL, BMOD, and vertical tilt angle increased, but BTA decreased with axial elongation of the globe in young, healthy patients with myopia. Longer BMOD was positively correlated with lower mChT, and smaller BTA was positively correlated with lower mChT and pChT in this population.

show abstract

Association between retinal microvasculature and optic disc alterations in high myopia

Cited by 59 publications

References 35 publications

Repeatability of Manual Measurement of Foveal Avascular Zone Area in Optical Coherence Tomography Angiography Images in High Myopia

Repeatability of Manual Measurement of Foveal Avascular Zone Area in Optical Coherence Tomography Angiography Images in High Myopia

Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study

Morphological Characteristics of the Optic Nerve Head and Choroidal Thickness in High Myopia

Contact Info

Product

Resources

About