Morphological Characteristics of the Optic Nerve Head and Choroidal Thickness in High Myopia

Abstract

This study aimed to explore the morphological characteristics of Bruch's membrane opening distance (BMOD), border length (BL), border tissue angle (BTA), vertical tilt angle, and peripapillary atrophy (PPA), as well as their associations with choroidal thickness (ChT) in young healthy highly myopic eyes. METHODS. A total of 167 patients with high myopia and 172 individuals without high myopia were enrolled. All of the subjects were divided by axial length. The PPA area was measured on fundus photographs. BMOD, BL, BTA, vertical tilt angle, macular ChT (mChT), and peripapillary ChT (pChT) were measured on swept-source optical coherence tomography scans. RESULTS. The PPA area (P < 0.0001) and vertical tilt angle (P < 0.0001) were larger, BMOD (P < 0.0001) and BL (P < 0.0001) were longer, and BTA (P < 0.0001) was smaller in the high-myopia group compared with the group without high myopia. Every 1-μm increase in BMOD was associated with a 35.80-μm decrease in mChT; every 1°decrease in BTA was correlated with a 0.32-μm decrease in mChT and a 0.26-μm decrease in pChT; and no association was found between PPA area and ChT in the multivariate linear regression model. CONCLUSIONS. PPA area, BL, BMOD, and vertical tilt angle increased, but BTA decreased with axial elongation of the globe in young, healthy patients with myopia. Longer BMOD was positively correlated with lower mChT, and smaller BTA was positively correlated with lower mChT and pChT in this population.

Associations between optic disc characteristics and macular choroidal microvasculature in young patients with high myopia

“…In the correlation analyses, the results indicated that thinning of the mCHT was related to the PPA area and the degree of optic disc tilt, but not the OI. These results are consistent with the results of Chen 13 and Hu et al 29 Among people with HM, thinning of the mCHT may also be affected by changes in optic disc tilt and increased PPA area, aside from the effects of AL. We further found that decreasing macular CCVD and CCF area were related to increasing PPA area.…”

Imaging Features by Machine Learning for Quantification of Optic Disc Changes and Impact on Choroidal Thickness in Young Myopic Patients

“…All subjects have understood the study protocol and signed informed consent forms. The protocol was consistent with those of previous studies ( 20 , 21 ).…”

“…The average thickness of all nine sectors was calculated in the macular region. While in the peripapillary area, only four regions of the outer ring were applied because no choroidal tissue was found in the central sector and the inner ring, and the topographic maps were not reliable in these regions ( 20 , 21 ).…”

Optic disc morphology and peripapillary atrophic changes in diabetic children and adults without diabetic retinopathy or visual impairment

“…Moreover, owing to the consistency in the measurement method used, the difference between the two groups should be reliable. Planimetric fundus photography was widely used in the measurement and analysis of PPA, ODO and ODA (Xu et al 2009;Kim et al 2019;Hu et al 2020); however, planimetric fundus photography analysis cannot reflect the spatial morphology; therefore, we hope that three-dimensional imaging technology will become available in the future to analyse the early changes in ODM and PPS around the disc affected by hyperglycaemia.…”

“… 2019 ; Hu et al. 2020 ); however, planimetric fundus photography analysis cannot reflect the spatial morphology; therefore, we hope that three‐dimensional imaging technology will become available in the future to analyse the early changes in ODM and PPS around the disc affected by hyperglycaemia.…”