Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study

Lin, Fengbin; Li, Fēi; Gao, Xinbo; He, Wanbing; Zeng, Jun; Chen, Yu; Chen, Mei‐Ling; Cheng, Weiqiang; Song, Yunhe; Peng, Yuying; Jin, Ling; Lin, Tse‐Chun; Wang, Yumeng; Tham, Clement C.; Cheung, Carol Y.

doi:10.1167/iovs.62.1.30

Cited by 24 publications

(17 citation statements)

References 53 publications

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“…The CC was delineated from the lower boundary of Bruch's membrane to 10.4 µm below this membrane. 17 , 21 , 22 The effects of projection and eye motion-related artifacts were minimized by the OCTA algorithm and the instrument's inbuilt active eye tracker. 17 All scans were reviewed by two trained graders (authors F. Lin and F. Li) to ensure that the images were of sufficient quality.…”

Section: Methodsmentioning

confidence: 99%

“…According to our previous study, density in the DCP reduced more quickly in primary open-angle glaucoma eyes with high myopia than in those without high myopia. 21 In this study, using the two-sample t -test, we calculated that a sample size of 31 per group with 80% power was required to detect a mean difference of 1.1% per year between the rates of the changes in CD in the DCP in the normal and high myopia groups, assuming means of −0.4% and −1.5%, respectively, with a common standard deviation of 1.5. 27 , 28 The sample size calculations were performed using the PASS 16.0 software (NCSS LLC, East Kaysville, UT, USA) and were based on a 2-sided significance level (alpha) of 0.05.…”

Section: Methodsmentioning

confidence: 99%

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Longitudinal Macular Retinal and Choroidal Microvasculature Changes in High Myopia

Lin

Zhao

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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Purpose The purpose of this study was to determine the longitudinal changes in macular retinal and choroidal microvasculature in normal healthy and highly myopic eyes. Methods Seventy-one eyes, including 32 eyes with high myopia and 39 healthy control eyes, followed for at least 12 months and examined using optical coherence tomography angiography imaging in at least 3 visits, were included in this study. Fovea-centered 6 × 6 mm scans were performed to measure capillary density (CD) of the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC). The rates of CD changes in both groups were estimated using a linear mixed model. Results Over a mean 14-month follow-up period, highly myopic eyes exhibited a faster rate of whole image CD (wiCD) loss (−1.44%/year vs. −0.11%/year, P = 0.001) and CD loss in the outer ring of the DCP (−1.67%/year vs. –0.14%/year, P < 0.001) than healthy eyes. In multivariate regression analysis, baseline axial length (AL) was negatively correlated with the rate of wiCD loss (estimate = −0.27, 95% confidence interval [CI] = −0.48 to −0.06, P = 0.012) and CD loss in the outer ring (estimate = −0.33, 95% CI = −0.56 to −0.11, P = 0.005), of the DCP. The CD reduction rates in the SCP and CC were comparable in both groups (all P values > 0.05). Conclusions The rate of CD loss in the DCP is significantly faster in highly myopic eyes than in healthy eyes and is related to baseline AL. The CD in the outer ring reduces faster in eyes with longer baseline AL.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Longitudinal Macular Retinal and Choroidal Microvasculature Changes in High Myopia

Lin

Zhao

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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“…A 3D vascular OCTA image is obtained by decoherence of the B-scan signal in two consecutive cross-sections, which divides the vessels into different layers for the purpose of blood flow detection. It is widely used in clinical practice and provides a non-invasive alternative for observing microvascular details (7)(8)(9). OCTA has been used in patients with Alzheimer's disease (AD) and it was found that the macular area thickness and central sulcus retinal thickness were decreased in both eyes in the AD group compared to normal controls (10).…”

Section: Introductionmentioning

confidence: 99%

Retinal Microvasculature and Conjunctival Vessel Alterations in Patients With Systemic Lupus Erythematosus—An Optical Coherence Tomography Angiography Study

et al. 2021

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Purpose: To evaluate the conjunctival and fundus retinal vessel density in patients with systemic lupus erythematosus (SLE) with optical coherence tomography angiography (OCTA), and to investigate the relationship between vessel density and clinical indicators.Methods: Twelve patients with SLE (24 eyes) and 12 healthy controls (24 eyes) were recruited. OCTA was used to examine the superficial retina layer (SRL) and deep retina layer (DRL) in the macular retina and conjunctival capillary plexus of each eye. We calculated the density of the temporal conjunctival vessels, fundus microvascular (MIR), macrovascular (MAR) and total MIR(TMI) and compared the results in both groups. We used annular partitioning (C1–C6), hemispheric quadrants, and Early Treatment Diabetic Retinopathy Study partitioning (ETDRS) to analyze changes in the retinal vascular density. Correlation analysis was used to investigate the association between blood capillary density and clinical indicators.Results: OCTA results showed significant differences in the conjunctival microvascular density (p < 0.001). There was no significant difference in MIR, TMI, and MAR in the superficial layers between the SLE and healthy group (p > 0.05). The DRL and DTMI (Deeper TMI) densities were decreased in the macular regions of SLE patients (p < 0.05). In the hemispheric segmentation analysis, the superficial MIR was significantly decreased in the IL (inferior left) region of the SLE patients (p < 0.05), and the deep MIR in the IR (inferior right) region was significantly reduced (p < 0.05). In the ETDRS partitioning analysis, the superficial MIR in the inferior, right, and left subdivisions was significantly decreased in the SLE patients (p < 0.05). In the circular segmentation analysis, the deep MIR in the C1 and C3 regions was significantly reduced in SLE patients (p < 0.05), while the superficial MIR density was decreased only in the C3 region (p < 0.05). The conjunctival vascular density was negatively correlated with the STMI (Superficial TMI) (r = −0.5107; p = 0.0108) and DTMI (r = −0.9418, p < 0.0001). There was no significant correlation between vascular density and SLEDAI-2k (Systemic Lupus Erythematosus Disease Activity Index−2000) (P > 0.05).Conclusion: Clinically, patients with SLE and patients suspected of SLE should receive OCTA examination in a comprehensive eye examination to detect changes in ocular microcirculation at an early stage.

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“… 6 One study found that myopic adults had reduced retinal vessel density and thinner retinas, correlated with AL, compared with adults with emmetropia. 7 However, there are few studies on children with myopia, especially those with high myopia. In the present study, the ZEISS Cirrus HD 5000A was used to scan a 3.0×3.0 mm area of the optic papillary by optical coherence tomography angiography (OCTA) for imaging and quantitative analysis of vessel density.…”

Section: Introductionmentioning

confidence: 99%

Study on the Optic Nerve Fiber Layer Thickness and Changes in Blood Flow in Myopic Children

Lin¹,

Su²,

Lin³

et al. 2021

IJGM

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Objective: The present study aims to observe the optic nerve fiber layer thickness and blood flow density in the papillary area and investigate the effects of axial length (AL) and the refractive state of the optic papilla blood flow density in children with different refractive conditions. Methods: The present study was a clinical control study. The right eyes of 204 minors aged 6-17 years were studied. The eyes were divided into four groups according to myopic refractive states. OCTA analyzed the data to compare the radial peripapillary capillary (RPC) density and the difference in the retinal nerve fiber layer (RNFL) thickness adjacent to the optic papilla between the four refraction groups. Results: The intra-optic disc blood flow density was significantly and negatively correlated with the AL and was negatively correlated with the AL in the inferior temporal quadrants. The RNFL in the superior, nasal, and inferior quadrants was negatively correlated with the AL. The RNFL in the temporal quadrant was positively correlated with the AL. Conclusion: Our present study revealed that aAs myopia increased and the AL grew in children, the blood density of the entire image of the optic papilla, in the optic disc, and the retinal capillaries in the inferior parapapillary and temporal quadrant would change significantly. With increasing AL, a significant decrease in the intra-disc and para-disc RNFL was observed in the superior, nasal, and inferior quadrants, while a substantial increase in RNFL was observed in the temporal quadrant.

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Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study

Cited by 24 publications

References 53 publications

Longitudinal Macular Retinal and Choroidal Microvasculature Changes in High Myopia

Longitudinal Macular Retinal and Choroidal Microvasculature Changes in High Myopia

Retinal Microvasculature and Conjunctival Vessel Alterations in Patients With Systemic Lupus Erythematosus—An Optical Coherence Tomography Angiography Study

Study on the Optic Nerve Fiber Layer Thickness and Changes in Blood Flow in Myopic Children

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