Study on the Optic Nerve Fiber Layer Thickness and Changes in Blood Flow in Myopic Children

Abstract

Objective: The present study aims to observe the optic nerve fiber layer thickness and blood flow density in the papillary area and investigate the effects of axial length (AL) and the refractive state of the optic papilla blood flow density in children with different refractive conditions. Methods: The present study was a clinical control study. The right eyes of 204 minors aged 6-17 years were studied. The eyes were divided into four groups according to myopic refractive states. OCTA analyzed the data to compare the radial peripapillary capillary (RPC) density and the difference in the retinal nerve fiber layer (RNFL) thickness adjacent to the optic papilla between the four refraction groups. Results: The intra-optic disc blood flow density was significantly and negatively correlated with the AL and was negatively correlated with the AL in the inferior temporal quadrants. The RNFL in the superior, nasal, and inferior quadrants was negatively correlated with the AL. The RNFL in the temporal quadrant was positively correlated with the AL. Conclusion: Our present study revealed that aAs myopia increased and the AL grew in children, the blood density of the entire image of the optic papilla, in the optic disc, and the retinal capillaries in the inferior parapapillary and temporal quadrant would change significantly. With increasing AL, a significant decrease in the intra-disc and para-disc RNFL was observed in the superior, nasal, and inferior quadrants, while a substantial increase in RNFL was observed in the temporal quadrant.

Altered retinal nerve fiber layer thickness in children with allergic conjunctivitis: the Nanjing eye study

“…Our study found that AL was negatively correlated with average macular thickness, average DVC density, perifoveal SVC density and average RNFL thickness, while positively correlated with foveal thickness and foveal vessel density, and similar findings have been reported in other researches [11,25,27,[29][30][31]. While some other studies found AL was positively correlated with SVC density and negatively correlated with RPC density [32,33]. Obese children tend to have higher values of foveal thickness, foveal SVC and DVC densities [34,35], comparing favorably with our study.…”

Characteristics of the Optic Nerve Head in Myopic Eyes Using Swept-Source Optical Coherence Tomography

“…We found that the mean and temporal RNFL thickness increased in myopia, which was consistent with a recent study. 34 The reason might be the redistribution of parapapillary nerve fibers as the eye grows in length. 20 However, some researchers found that RNFL thickness was negatively correlated or had no relationship with AL using OCT. 35 , 36 The configuration of the myopic optic disc still remains controversial.…”

“…Furthermore, the changes in the flow density around the optic papilla are reported to precede those in the macula. 34 In addition, monitoring RPC blood flow is of great significance for the early diagnosis of patients with high myopia or glaucoma. Limited information is available on the peripapillary CVI in myopic eyes.…”

Parameters of the Optic Nerve Head as Markers of Myopia Progression

“…Сравнение толщины СНВС в 10 секторах ДЗН выявило тенденцию к ее уменьшению в нижнем (6), назальном верхнем (9) и верхнем (1) секторах ДЗН по мере удлинения глазного яблока (табл. 4), что согласуется с результатами, полученными другими авторами [16,17].…”