Association between renal dysfunction and 3-year mortality in patients with acute first-ever ischemic stroke

Renal Function Predicts Outcomes in Patients with Ischaemic Stroke and Haemorrhagic Stroke

“…In our study, CKD (defined as eGFR <60 mL/min/1.73 m 2 by KDIGO) occurred in 31.1% -34.9% patients with stroke (depending on the equation MDRD or CKD-EPI), similarly to the study of Ovbiagele et al [18]. In the study by Lin et al [19] on 934 patients with acute first-ever ischaemic stroke, 28.3% had a reduced eGFR, but serum creatinine levels were obtained within 3 days of acute stroke onset. In contrast, Xu et al [20] found the presence of CKD in 47.7% patients with incident cerebrovascular lesions.…”

“…Mac Walter et al [25] reported that after acute stroke, patients with reduced calculated creatinine clearance at admission and raised serum creatinine had a higher mortality risk (follow-up was up to 7 years) similar to the study of Lin et al [26]. In another study on patients with ischaemic stroke it was found that the reduction in GFR was associated with higher mortality [27].…”

“…Similarly, in the pooled analyses of 4 prospective community-based cohorts, including Atherosclerosis Risk in Communities Study (ARIC), the Cardiovascular Heart Study (CHS), the Multi-Ethnic Study of Atherosclerosis (MESA) and the Prevention of Renal and Vascular End-stage Disease (PREVEND) Study, the low eGFR was significantly associated with increased risk of ischaemic, but not haemorrhagic, stroke risk, while high albumin/creatinine ratio was associated with both stroke types [8]. Moreover, Lin et al [19] found that reduced eGFR during the acute stroke stage was associated with increased risk of 3-year mortality. Furthermore, the risk of acute complications and poor functional outcomes following discharge was significantly higher in patients with a reduced eGFR [19].…”

“…Moreover, Lin et al [19] found that reduced eGFR during the acute stroke stage was associated with increased risk of 3-year mortality. Furthermore, the risk of acute complications and poor functional outcomes following discharge was significantly higher in patients with a reduced eGFR [19].…”

Association between Clinical and Laboratory Markers and 5-year Mortality among Patients with Stroke

“…Previous literature has discussed that impaired renal function affects long-term mortality in patients with stroke. Estimated glomerular filtration rate <60 mL/min/1.73 m 2 , calculated with a formula using serum creatinine levels in the 3 days after acute stroke, was a significant predictor of 3-year mortality (HR = 1.67) 34 . Although the serum creatinine level can be affected by other factors and may not precisely reflect renal function, it currently remains as the first-line routine evaluation of renal function in patients with acute stroke.…”