Association between prenatal depression and new cardiovascular disease within 24 months’ postpartum

Ackerman-Banks, Christina; Lipkind, Heather S.; Palmsten, Kristin; Pfeiffer, Mariah; Gelsinger, Catherine; Ahrens, Katherine A.

doi:10.1016/j.ajog.2022.11.777

Cited by 2 publications

(3 citation statements)

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“…23,24 Moreover, a significant association between prenatal depression and new CVD within 24 months postpartum has been described. 25 During pregnancy Pregnant women with CVD are at a higher risk of experiencing adverse cardiovascular outcomes, such as heart failure, arrhythmias, myocardial infarction, stroke, and aortic dissection. 3,6,26 In addition, they are at an increased risk of obstetric complications, such as preterm delivery, gestational hypertension, and preeclampsia, which can further exacerbate their cardiovascular risk.…”

Section: Before Pregnancymentioning

confidence: 99%

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Cardiovascular risk stratification in young women: the pivotal role of pregnancy

Mattioli,

Coppi,

Bucciarelli

et al. 2023

Journal of Cardiovascular Medicine

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Section: Before Pregnancymentioning

confidence: 99%

“…Similarly, an increasing role of depression on cardiovascular risk, especially in women and during the COVID-19 pandemic, has been advocated 23,24 . Moreover, a significant association between prenatal depression and new CVD within 24 months postpartum has been described 25 …”

Section: Before Pregnancymentioning

confidence: 99%

Cardiovascular risk stratification in young women: the pivotal role of pregnancy

Mattioli,

Coppi,

Bucciarelli

et al. 2023

Journal of Cardiovascular Medicine

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“…Immigrant women and women of color may be at increased risk of perinatal and postpartum depression due to chronic experiences of discrimination and the confluence of other stressors associated with their intersectional identity [3]. Perinatal depression can increase the risk of other adverse maternal health outcomes, including all-cause mortality and suicide [4], cardiovascular conditions [5], and autoimmune disease -although evidence suggests bidirectional relationships [6]. Furthermore, perinatal depression can also impact child health outcomes.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Perturbations Associated with both PFAS Exposure and Perinatal/Antenatal Depression in Pregnant Individuals: A Meet-in-the-Middle Scoping Review

Suthar,

Tanghal,

Chatzi

et al. 2024

Curr Envir Health Rpt

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Purpose of Review Depression during the perinatal or antenatal period affects at least 1 in 10 women worldwide, with long term health implications for the mother and child. Concurrently, there is increasing evidence associating maternal exposure to per- and poly-fluoroalkyl substances (PFAS) to adverse pregnancy outcomes. We reviewed the body of evidence examining both the associations between PFAS exposure and perturbations in the maternal metabolome, and the associations between the maternal metabolome and perinatal/antenatal depression. Through this, we sought to explore existing evidence of the perinatal metabolome as a potential mediation pathway linking PFAS exposure and perinatal/antenatal depression. Recent Findings There are few studies examining the metabolomics of PFAS exposure—specifically in pregnant women—and the metabolomics of perinatal/antenatal depression, let alone studies examining both simultaneously. Of the studies reviewed (N = 11), the majority were cross sectional, based outside of the US, and conducted on largely homogenous populations. Our review identified 23 metabolic pathways in the perinatal metabolome common to both PFAS exposure and perinatal/antenatal depression. Summary Future studies may consider findings from our review to conduct literature-derived hypothesis testing focusing on fatty acid metabolism, alanine metabolism, glutamate metabolism, and tyrosine metabolism when exploring the biochemical mechanisms conferring the risk of perinatal/antenatal depression due to PFAS exposure. We recommend that researchers also utilize heterogenous populations, longitudinal study designs, and mediation approaches to elucidate key pathways linking PFAS exposures to perinatal/antenatal depression.

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Association between prenatal depression and new cardiovascular disease within 24 months’ postpartum

Cited by 2 publications

References 0 publications

Cardiovascular risk stratification in young women: the pivotal role of pregnancy

Cardiovascular risk stratification in young women: the pivotal role of pregnancy

Metabolic Perturbations Associated with both PFAS Exposure and Perinatal/Antenatal Depression in Pregnant Individuals: A Meet-in-the-Middle Scoping Review

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