Association Between Prediagnostic Serum 25-Hydroxyvitamin D Concentration and Glioma

Zigmont, Victoria A.; Garrett, Amy; Peng, Jin; Seweryn, Michał; Rempała, Grzegorz A.; Harris, Randall E.; Holloman, Christopher; Gundersen, Thomas E.; Ahlbom, Anders; Feychting, Maria; Johannesen, Tom Børge; Grimsrud, Tom Kristian; Schwartzbaum, Judith A.

doi:10.1080/01635581.2015.1073757

Cited by 23 publications

(17 citation statements)

References 59 publications

(57 reference statements)

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“…While vitamin D and its metabolites have been shown to induce death of glioblastoma cells 20 – 22 , only one epidemiological study has investigated the relationship between pre-diagnostic levels of 25(OH)D and glioma risk 23 . Researchers found that higher levels of 25(OH)D were protective against high-grade glioma in men over the age of 56 (OR = 0.59), although the reverse trend was shown in men under the age of 56, albeit at a borderline-significant level 23 . Excluding the possibility of post hoc data mining, such paradoxical findings would support distinct aetiologies between the GBM and non-GBM subtypes, as has been suggested previously 9 .…”

Section: Discussionmentioning

confidence: 99%

Mendelian randomisation study of the relationship between vitamin D and risk of glioma

Takahashi

Cornish

Sud

et al. 2018

Sci Rep

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To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach unaffected by biases from confounding. Two-sample MR was undertaken using genome-wide association study data. Single nucleotide polymorphisms (SNPs) associated with 25(OH)D levels were used as instrumental variables (IVs). We calculated MR estimates for the odds ratio (OR) for 25(OH)D levels with glioma using SNP-glioma estimates from 12,488 cases and 18,169 controls, using inverse-variance weighted (IVW) and maximum likelihood estimation (MLE) methods. A non-significant association between 25(OH)D levels and glioma risk was shown using both the IVW (OR = 1.21, 95% confidence interval [CI] = 0.90–1.62, P = 0.201) and MLE (OR = 1.20, 95% CI = 0.98–1.48, P = 0.083) methods. In an exploratory analysis of tumour subtype, an inverse relationship between 25(OH)D levels and glioblastoma (GBM) risk was identified using the MLE method (OR = 0.62, 95% CI = 0.43–0.89, P = 0.010), but not the IVW method (OR = 0.62, 95% CI = 0.37–1.04, P = 0.070). No statistically significant association was shown between 25(OH)D levels and non-GBM glioma. Our results do not provide evidence for a causal relationship between 25(OH)D levels and all forms of glioma risk. More evidence is required to explore the relationship between 25(OH)D levels and risk of GBM.

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Section: Discussionmentioning

confidence: 99%

Mendelian randomisation study of the relationship between vitamin D and risk of glioma

Takahashi

Cornish

Sud

et al. 2018

Sci Rep

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“…glioma risk in men >56 at diagnosis (Zigmont et al, 2015). A Mendelian randomization study showed that there is an inverse relationship between 25(OH)D levels and glioblastoma risk using the inverse-variance weighted method (Takahashi et al, 2018).…”

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confidence: 99%

Histone demethylase KDM6B regulates 1,25‐dihydroxyvitamin D3‐induced senescence in glioma cells

Sui

Pan

et al. 2019

Journal Cellular Physiology

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Vitamin D is a fat‐soluble vitamin and plays an important role in calcium absorption and bone development, whose lack can cause a variety of diseases, including cancer. Human epidemiological studies suggested that vitamin D3 deficiency might increase glioma incidence, but molecular mechanism is less understood. In this study, we show that 1,25‐dihydroxyvitamin D3 (the active form of vitamin D3) induces senescence of glioma cells and increases the expression of senescence markers, INK4A and cyclin‐dependent kinase inhibitor 1A (CDKN1A). 1,25‐Dihydroxyvitamin D3 also upregulates the expression of histone demethylase, KDM6B. Knockdown of KDM6B attenuates 1,25‐dihydroxyvitamin D3‐induced senescence and upregulation of INK4A and CDKN1A. KDM6B promotes the transcription of INK4A by eliminating the trimethylation of repressive marker H3K27me3 near its promoter. This study reveals a new regulatory mechanism involved in vitamin D3 inhibition on gliomas, which is beneficial to prevention and adjuvant therapy of glioma.

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“…Zigmont et al in 2015 published the fi rst study in which they evaluate a potential association between pre-diagnostic serum vitamin D and glioma risk. They found that men older than 56 years with higher levels of serum 25(OH)D had a reduced risk of glioma (60).…”

Section: Discussionmentioning

confidence: 99%

Low serum vitamin D levels are associated with a low percentage of TREM-2+ monocytes in low-grade gliomas and poorer overall survival in patients with high-grade gliomas

Kluckova¹,

Kozák²,

Szaboova³

et al. 2021

BLL

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INTRODUCTION: Anti-infl ammatory effect of vitamin D (VD) could be benefi cial in improving the survival of glioma patients. The aim of our study was to analyse the serum levels of vitamin D in glioma patients and to fi nd an association with the prognosis of glioma patients and other investigated parameters. MATERIAL AND METHODS: The study included 63 patients with gliomas. Percentage of CD14 + monocytes, TREM-1 + and TREM-2 + monocytes were determined by fl ow cytometry, serum levels of 25(OH)D were evaluated by electrochemiluminescent binding test. RESULTS: Six patients out of 63 had normal levels of VD. A signifi cant difference in the overall survival (OS) in the patients with severe VD defi ciency, VD defi ciency and insuffi ciency in grade IV was found. In grade II and III, the levels of vitamin D positively correlated with the percentage of TREM-2 + monocytes, and in grade II also a negative correlation of VD with TREM-1/TREM-2 ratio was observed. CONCLUSION: Levels of VD could infl uence the prognosis of patients with high-grade gliomas. Serum level of 25(OH)D in low-grade gliomas positively correlated with the percentage of anti-infl ammatory acting TREM-2 + monocytes and negatively with TREM-1/TREM-2 ratio. This could be protective against the progression to high-grade glioma, because TREM-2 is associated with protective functions such as: tissue repair, control of local infl ammation, or phagocytosis (Tab. 4, Fig. 4, Ref. 79).

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Association Between Prediagnostic Serum 25-Hydroxyvitamin D Concentration and Glioma

Cited by 23 publications

References 59 publications

Mendelian randomisation study of the relationship between vitamin D and risk of glioma

Mendelian randomisation study of the relationship between vitamin D and risk of glioma

Histone demethylase KDM6B regulates 1,25‐dihydroxyvitamin D3‐induced senescence in glioma cells

Low serum vitamin D levels are associated with a low percentage of TREM-2+ monocytes in low-grade gliomas and poorer overall survival in patients with high-grade gliomas

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