2019
DOI: 10.1002/jcp.28431
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Abstract: Vitamin D is a fat‐soluble vitamin and plays an important role in calcium absorption and bone development, whose lack can cause a variety of diseases, including cancer. Human epidemiological studies suggested that vitamin D3 deficiency might increase glioma incidence, but molecular mechanism is less understood. In this study, we show that 1,25‐dihydroxyvitamin D3 (the active form of vitamin D3) induces senescence of glioma cells and increases the expression of senescence markers, INK4A and cyclin‐dependent kin… Show more

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Cited by 12 publications
(13 citation statements)
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“…In addition, the administration of EM1 in nude mice did not produce hypercalcaemia or other side effects. An additional mechanism for the action(s) of vitamin D in glioma cells was proposed by Sui et al, who reported that 1,25‐dihydroxyvitamin D 3 increased the expression of senescence markers INK4A and cyclin‐dependent kinase inhibitor 1A (CDKN1A) in human glioblastoma cell lines U87 and U251. These findings suggest that one of the mechanisms for the inhibition of growth by 1,25‐dihydroxyvitamin D 3 (and possibly vitamin D‐like compounds) in glioma might be the induction of senescence.…”
Section: Vitamin D and Inhibition Of Cellular Proliferation: A Role Imentioning
confidence: 99%
“…In addition, the administration of EM1 in nude mice did not produce hypercalcaemia or other side effects. An additional mechanism for the action(s) of vitamin D in glioma cells was proposed by Sui et al, who reported that 1,25‐dihydroxyvitamin D 3 increased the expression of senescence markers INK4A and cyclin‐dependent kinase inhibitor 1A (CDKN1A) in human glioblastoma cell lines U87 and U251. These findings suggest that one of the mechanisms for the inhibition of growth by 1,25‐dihydroxyvitamin D 3 (and possibly vitamin D‐like compounds) in glioma might be the induction of senescence.…”
Section: Vitamin D and Inhibition Of Cellular Proliferation: A Role Imentioning
confidence: 99%
“…Preclinical studies using differentiated GBM cell lines employed VitD3-loaded nanoparticles to induce cytotoxicity in rat glioma cells [23] and combined VitD3 with Temozolomide, leading to synergistic cytotoxicity via enhancement of autophagy [24]. Mechanistically it was shown that calcitriol induces senescence in conventional, FCS-grown glioma cell lines [25]. Importantly, a synthetic derivative of calcitriol, alfacalcidol, has already been tested in a small patient cohort in France as an adjuvant therapy and it was reported that from 11 patients analyzed (10 GBMs, 1 Anaplastic Astrocytoma [AA]) 3 patients showed continuous improvement and finally complete regression of the tumor (2 GBM, 1 AA) and the median survival of all patients was 21 months, with the two GBM responders still alive after 4 years of follow-up [26].…”
Section: Introductionmentioning
confidence: 99%
“…These wide effects of vitamin D are driven through its receptor VDR, which also acts as a transcription factor [5,13]. Recent clinical studies revealed the association of differential expressional patterns of vitamin D with various cancer types [16,17,19,20,[31][32][33]. Indeed, preclinical studies have shown that calcitriol or its analogues might have potential therapeutic effect as an anticancer agent [5-8, 13, 15, 34].…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, the inhibitors of CDKs such as p16, p21 and p27 suppress the activation of cyclin-cyclin dependent kinase (C-CDK) complex, so the lack of activation of C-CDK results in the inhibition of cell cycle progression in the G0/G1 phase. This interaction describes the mechanism by which calcitriol prevents the proliferation of tumor cells [16][17][18].…”
Section: Introductionmentioning
confidence: 99%