“…The associations between IL27p28 polymorphisms and the risk of various diseases such as asthma [ 13 – 18 , 36 – 43 ], chronic obstructive pulmonary disease [ 13 – 18 , 37 – 43 ], coronary heart disease [ 13 – 18 , 38 – 43 ], rheumatoid arthritis [ 14 – 18 , 38 – 43 ], inflammatory bowel disease [ 14 – 18 , 39 – 43 ], pulmonary tuberculosis [ 15 – 18 , 40 – 43 ], allergic rhinitis [ 15 – 18 , 41 – 43 ], HCV infection [ 16 – 18 , 41 – 43 ], and several tumors (e.g., esophageal cancer [ 16 – 18 , 42 , 43 ], nasopharyngeal carcinoma [ 16 , 17 , 42 , 43 ], ovarian [ 16 , 17 ], and bladder [ 16 ] cancer) have also been detected. Therefore, IL27p28 polymorphisms have been investigated in this study.…”