Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement

Huang, Ming-Yuan; Du, Wenjing; Lee, Jun; Zhang, Haiyang; Cao, Liangqi; Yang, Weiqing; Zhang, Hui; Wang, Zhiyong; Pei, Wei; Wu, Weiquan; Huang, Zhulin; Fang, Ying; Lin, Qiling; Qin, Xingwen; Zhang, Zhizhong; Zhou, Keyuan; Zeng, Jincheng

doi:10.1155/2016/4025167

Cited by 7 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IL-27 is produced by the activation of antigenpresenting cells in the early stage, promoting the proliferation of naive T cells, and cooperating with IL-12 to stimulate the production of IFN-γ in T cells and promoting the early Th1 cells [47]. Our previous study [44] found that serum IL-27 levels were distinctly higher in clinical stage III (early cardiopulmonary failure) EV71-infected HFMD patients than in clinical stage II (involvement of the nervous system) or clinical stage IV (cardiopulmonary failure) EV71-infected patients, which suggested that IL-27 may play a role in HFMD caused by EV71 infection, especially in patients with early cardiopulmonary failure. 6.5.…”

Section: Il-13mentioning

confidence: 97%

Predicting Severe Enterovirus 71-Infected Hand, Foot, and Mouth Disease: Cytokines and Chemokines

Zhang

Huang

et al. 2020

Mediators of Inflammation

Self Cite

View full text Add to dashboard Cite

Enterovirus 71 (EV71) is one of the most common intestinal virus that causes hand, foot, and mouth disease (HFMD) in infants and young children (mostly ≤5 years of age). Generally, children with EV71-infected HFMD have mild symptoms that resolve spontaneously within 7-14 days without complications. However, some EV71-infected HFMD cases lead to severe complications such as aseptic meningitis, encephalitis, acute flaccid paralysis, pulmonary edema, cardiorespiratory complication, circulatory disorders, poliomyelitis-like paralysis, myocarditis, meningoencephalitis, neonatal sepsis, and even death. The mechanism of EV71 pathogenesis has been studied extensively, and the regulation of host immune responses is suspected to aggravate EV71induced severe complications. Recently, several cytokines or chemokines such as TNF-α, IFN-γ, IL-1β, IL-18, IL-33, IL-37, IL-4, IL-13, IL-6, IL-12, IL-23, IL-27, IL-35, IL-10, IL-22, IL-17F, IL-8, IP-10, MCP-1, G-CSF, and HMGB1 have been reported to be associated with severe EV71 infection by numerous research teams, including our own. This review is aimed at summarizing the pathophysiology of the cytokines and chemokines with severe EV71 infection.

show abstract

Section: Il-13mentioning

confidence: 97%

Predicting Severe Enterovirus 71-Infected Hand, Foot, and Mouth Disease: Cytokines and Chemokines

Zhang

Huang

et al. 2020

Mediators of Inflammation

Self Cite

View full text Add to dashboard Cite

show abstract

“…Enterovirus, which causes HFMD, significantly increases the release of circulating inflammatory mediators (23). Interleukin (IL)-27 is associated with early cardiopulmonary failure in enterovirus-induced HFMD (24). Cytokines and chemokines play a role in the development of HFMD (25).…”

Section: Results Of the Subgroup Analysesmentioning

confidence: 99%

Association between platelet count and the risk and progression of hand, foot, and mouth disease among children

Li¹,

Liu²,

Luo³

et al. 2020

Clinics

View full text Add to dashboard Cite

We aimed to evaluate the association between platelet (PLT) count and the risk and progression of hand, foot, and mouth disease (HFMD). METHODS: In total, 122 HFMD patients and 40 healthy controls were enrolled in the study. The differences between variables among the different subgroups were compared. Logistic regression analyses were performed to assess the relationship between various parameters and HFMD risk/progression. Sensitivity analysis was conducted by detecting the trend of the association between PLT count quartiles and HFMD risk/progression. A generalized additive model was used to identify the nonlinear relationship between PLT count and HFMD risk/ progression. The relationship between gender and PLT count as well as the risk/progression of HFMD was detected using a stratified logistic regression model. RESULTS: Significant differences were observed in terms of age, male/female ratio, white blood cell (WBC) count, and PLT count between patients with stage I-II, III-IV HFMD and healthy controls. Moreover, the alanine aminotransferase and magnesium levels between patients with stage I-II and III-IV HFMD significantly differed. Moreover, a significant difference was noted in the male/female ratio among the different PLT groups. The group with a low PLT count had a lower risk of HFMD progression than the group with a high PLT count (Q4) (p=0.039). Lower age, male gender, and WBC count were found to be associated with HFMD risk. Meanwhile, PLT count was correlated to HFMD progression. The sensitivity analysis yielded a similar result using the minimally adjusted model (p for trend=0.037), and minimal changes were observed using the crude and fully adjusted model (p for trend=0.054; 0.090). A significant nonlinear relationship was observed between PLT count and HFMD progression after adjusting for age, gender, and WBC (p=0.039). CONCLUSIONS: PLT was independently associated with HFMD progression in a nonlinear manner.

show abstract

“…We adopted the diagnostic criteria for HFMD disease with EV71 infection set out in the Chinese guidelines for the diagnosis and treatment of HFMD (2018 edition) ( 20 ). Reverse transcription polymerase chain reaction (RT-PCR) was used to conduct the stool test to determine if the participants were positive for the EV71 virus as previously reported ( 6 , 21 ). The demographic and clinical characteristics of all the study participants are set out in Table 1 .…”

Section: Methodsmentioning

confidence: 99%

The upregulation of peripheral blood polyamine metabolites spermidine and spermine in children with hand, foot, mouth disease is related to enterovirus 71 capsid protein VP1, but not VP4

Liu¹,

Zhang²,

Chang³

et al. 2023

Transl Pediatr

Self Cite

View full text Add to dashboard Cite

Background: Hand, foot, and mouth disease (HFMD) is a common viral childhood illness caused most commonly by enterovirus 71 (EV71) and coxsackievirus A16. The pathogenesis of EV71 has been extensively studied, and the regulation of the host immune response is suspected to aggravate the serious complications induced by EV71. Our previous research showed that EV71 infection significantly increased the release of circulating interleukin (IL)-6, IL-10, IL-13, and IL-27. Notably, these cytokines are related to the EV71 infection risk and clinical stage. Polyamines are compounds that are ubiquitous in mammalian cells and play a key role in various cellular processes. Several studies have shown that targeting polyamine metabolic pathways can reduce infections caused by viruses. However, the significance of polyamine metabolism in EV71 infection remains largely unknown.Methods: Serum samples from 82 children with HFMD and 70 healthy volunteers (HVs) were collected to determine the polyamine metabolites spermidine (SPD) and spermine (SPM), and IL-6 levels. In addition, peripheral blood mononuclear cells (PBMCs) were treated with EV71 viral protein 1 (VP1) and EV71 VP4, and the cells and supernatant were then collected to analyze the expression of polyamine metabolism-related enzymes by western blot. The data were analyzed using GraphPad Prism 7.0 software (USA). Results:The serum polyamine metabolites SPD and SPM were elevated in the HFMD patients, especially in the EV71-infected children. Further, a positive correlation was found between serum SPD and IL-6 levels in the EV71-infected children. We also found that the upregulation of peripheral blood polyamine metabolites in the EV71-infected HFMD children was related to EV71 capsid protein VP1, but not VP4.VP1 may promote the expression of polyamine metabolism-related enzymes and promote the production of polyamine metabolites, thereby upregulating the SPD/nuclear factor kappa B/IL-6 signaling pathway.However, VP4 has the opposite effect in this process.Conclusions: Our results suggest that EV71 capsid protein may regulate the polyamine metabolic pathways of infected cells in a variety of ways. This study provides insights into the mechanism of EV71

show abstract

Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement

Cited by 7 publications

References 40 publications

Predicting Severe Enterovirus 71-Infected Hand, Foot, and Mouth Disease: Cytokines and Chemokines

Predicting Severe Enterovirus 71-Infected Hand, Foot, and Mouth Disease: Cytokines and Chemokines

Association between platelet count and the risk and progression of hand, foot, and mouth disease among children

The upregulation of peripheral blood polyamine metabolites spermidine and spermine in children with hand, foot, mouth disease is related to enterovirus 71 capsid protein VP1, but not VP4

Contact Info

Product

Resources

About