Association between physical activity energy expenditure and inflammatory markers in sedentary overweight and obese women

Lavoie, Marie-Ève; Rabasa‐Lhoret, Rémi; Doucet, Éric; Mignault, Diane; Messier, Lyne; Bastard, J.-P.; Faraj, May

doi:10.1038/ijo.2010.55

Cited by 40 publications

(32 citation statements)

References 50 publications

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“…Cross-sectional data indicate that higher levels of physical activity are associated with lower levels of CRP (1,8,10,18,21,23), IL-6 (8,21,23), and leptin (23). However, data are inconsistent as to whether these relationships are independent or attenuated by estimates of body fat, including BMI, waist circumference, and waist-to-hip ratio.…”

Section: Discussionmentioning

confidence: 99%

Physical Activity and Adiposity-related Inflammation

Vella

Allison

Cushman

et al. 2017

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose Physical activity is associated with decreased adiposity-related inflammation in adults. Whether this association is independent of central obesity is unknown but important for understanding the mechanisms associated with reducing cardiometabolic disease risk through physical activity. This study examined whether associations of physical activity and obesity-related inflammatory markers were independent of central adiposity. Methods Between 2002 and 2005, 1970 participants from the Multi-Ethnic Study of Atherosclerosis completed detailed health history and physical activity questionnaires, underwent physical measurements including computed tomography to quantify abdominal visceral and subcutaneous fat, and measurements of adiponectin, leptin, interleukin-6, tumor necrosis factor-alpha, and resistin. Statistical analyses included analysis of covariance and multivariable-adjusted regression. Results The mean (range) age of participants was 64.7 (55-84) years and 50% were female. After adjustment for age and sex, and compared to the lowest quartile, inflammatory markers in the highest quartile of moderate-to-vigorous physical activity were 16% higher for adiponectin and 30%, 26% and 9% lower for leptin, interleukin-6, and resistin, respectively (p<0.05 for all). In linear regression adjusted for demographics, dyslipidemia, hypertension, diabetes, smoking, glomerular filtration rate, renin and aldosterone, each standard deviation increment of moderate-to-vigorous physical activity was associated with significantly higher levels of adiponectin (β=0.04) and lower levels of leptin (β=−0.06), interleukin-6 (β=−0.08), and resistin (β=−0.05, p<0.05 for all). The associations with leptin, interleukin-6, and resistin were independent of total and central adiposity (p<0.05), whereas the association between moderate-to-vigorous physical activity and adiponectin was attenuated by central adiposity (p>0.05). There were no significant interactions by race/ethnicity or sex. Conclusions Moderate-to-vigorous physical activity was associated with a more favorable profile of inflammatory markers, independent of relevant cardiometabolic disease risk factors including central obesity.

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Section: Discussionmentioning

confidence: 99%

Physical Activity and Adiposity-related Inflammation

Vella

Allison

Cushman

et al. 2017

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Physical activity may limit obesity-related inflammation in some cases. For example, postmenopausal, overweight women with higher energy expenditure (i.e., kilocalories burned) throughout the day had lower levels of CRP than their more sedentary counterparts, even after adjusting for fat mass [84]. …”

Section: Biopsychosocial Risk Factors For Elevated Inflammationmentioning

confidence: 99%

Sex Differences in Depression: Does Inflammation Play a Role?

Derry

Padin

Kuo

et al. 2015

Curr Psychiatry Rep

134

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Women become depressed more frequently than men, a consistent pattern across cultures. Inflammation plays a key role in initiating depression among a subset of individuals, and depression also has inflammatory consequences. Notably, women experience higher levels of inflammation and greater autoimmune disease risk compared to men. In the current review, we explore the bidirectional relationship between inflammation and depression and describe how this link may be particularly relevant for women. Compared to men, women may be more vulnerable to inflammation-induced mood and behavior changes. For example, transient elevations in inflammation prompt greater feelings of loneliness and social disconnection for women than for men, which can contribute to the onset of depression. Women also appear to be disproportionately affected by several factors that elevate inflammation, including prior depression, somatic symptomatology, interpersonal stressors, childhood adversity, obesity, and physical inactivity. Relationship distress and obesity, both of which elevate depression risk, are also more strongly tied to inflammation for women than for men. Taken together, these findings suggest that women’s susceptibility to inflammation and its mood effects may contribute to sex differences in depression. Depression continues to be a leading cause of disability worldwide, with women experiencing greater risk than men. Due to the depression-inflammation connection, these patterns may promote additional health risks for women. Considering the impact of inflammation on women’s mental health may foster a better understanding of sex differences in depression, as well as the selection of effective depression treatments.

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“…Moderate-intensity physical activity (16-week endurance training program consisting of 3 sessions/week of 45-minute walking at approximately 60% of heart rate reserve) has been deemed as sufficient to reduce both systolic and diastolic blood pressure in postmenopausal women [47]. Lavoie et al [52] have also reported physical activity as an independent predictor of us-CRP levels in postmenopausal women. Those authors suggested that physical activity could potentially reduce subclinical inflammation and the risk of metabolic and cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 97%