2008
DOI: 10.1590/s1806-83242008000500006
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Association between periodontal diseases and systemic diseases

Abstract: Current evidence suggests that periodontal disease may be associated with systemic diseases. This paper reviewed the published data about the relationship between periodontal disease and cardiovascular diseases, adverse pregnancy outcomes, diabetes and respiratory diseases, focusing on studies conducted in the Brazilian population. Only a few studies were found in the literature focusing on Brazilians (3 concerning cardiovascular disease, 7 about pregnancy outcomes, 9 about diabetes and one regarding pneumonia… Show more

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Cited by 63 publications
(55 citation statements)
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“…Moreover, inflammatory cytokines, amongst others, IL-17 provide a viable link between periodontal disease and systemic disease [19]. Periodontal disease is also considered a risk factor for an assortment of systemic diseases ranging from exacerbated cardiovascular disease, to rheumatoid arthritis [19,45]. Understanding the degree to which VDR agonists are capable of regulating inflammatory cytokines involved in both oral and systemic diseases whilst enhancing the intracellular lysing capacity of cells of the immune system would thus be of great therapeutic significance in periodontal disease as well as a wide-range of systemic disease.…”
Section: Vdr Agonistsmentioning
confidence: 99%
“…Moreover, inflammatory cytokines, amongst others, IL-17 provide a viable link between periodontal disease and systemic disease [19]. Periodontal disease is also considered a risk factor for an assortment of systemic diseases ranging from exacerbated cardiovascular disease, to rheumatoid arthritis [19,45]. Understanding the degree to which VDR agonists are capable of regulating inflammatory cytokines involved in both oral and systemic diseases whilst enhancing the intracellular lysing capacity of cells of the immune system would thus be of great therapeutic significance in periodontal disease as well as a wide-range of systemic disease.…”
Section: Vdr Agonistsmentioning
confidence: 99%
“…Respiratory disease are the diseases of the respiratory system that range from common cold to life threatening diseases like asthma, COPD and pneumonia [6].COPD is one of the most common respiratory diseases and is projected to be the fourth leading cause of death worldwide by 2030 and places a huge economic burden on society [7]. The disease is characterized by airflow limitation that is not fully reversible, which is caused by a combination of obstructive bronchiolitis (also known as chronic bronchitis) and destruction of alveoli resulting in airspace enlargement (also known as emphysema) [8].The main risk factor for COPD is smoking, however, air pollutants, respiratory infections, genetic factors and hereditary are among other risk factors of COPD [3].…”
Section: Risk Factors For Copdmentioning
confidence: 99%
“…Respiratory diseases is the term for diseases of the respiratory system, including lung, pleural cavity, bronchial tubes, trachea and upper respiratory tract. They range from a common cold to life threatening conditions such as bacterial pneumonia or chronic obstructive pulmonary disease (COPD), which are important causes of death worldwide (Weidlich et al, 2008). COPD is currently the fourth leading cause of death in the world and further increase in the prevalence and mortality of the disease can be predicted in the coming decades (Pauwels et al, 2001).…”
Section: Periodontal Disease and Respiratory Diseasementioning
confidence: 99%
“…Pneumonia (both community-acquired and hospital acquired) is an acute infection of the lung and is characterized by cough, breath shortness, sputum production and chest pain. It is caused by the micro-aspiration of oropharyngeal secretions containing bacteria into the lung, and failure of the host to clear the bacteria (Weidlich et al, 2008).…”
Section: Periodontal Disease and Respiratory Diseasementioning
confidence: 99%