The Emerging Concepts on the Impact of Periodontitis on Systemic Health

Anil, Sukumaran; Varma, Sanjay; Preethanath, Reghunathan S.; Anand, Pradeep S.; Aldosari, Abdullah Al Farraj

doi:10.5772/26457

Cited by 6 publications

(5 citation statements)

References 149 publications

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“…Those bacteria produce and release enzymes that deconstruct the extra-cellular matrix components including collagen, process that results in production of substrates that enhance tissue invasion [80]. Those bacterial enzymes, endotoxins, and metabolic by products are toxic to tissues, may cause direct damage to neighboring epithelial cells DNA, and they can induce mutations in protooncogenes and tumor suppressor genes, or cause alterations in molecular signaling pathways implicated in cell survival, proliferation or differentiation [79]. Oral bacteria may promote carcinogenesis by constitutively activating toll-like receptors, such as toll-like receptor 5 (TLR5) [80].…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Association between Periodontal Disease Indices and Risk of Acute Hematopoietic Cancer Development (Acute Myeloid and Acute Lymphoblastic Leukemia): A Case – Control Study

Chrysanthakopoulos¹,

Vryzaki²

2022

SJMH

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The objective of the current research was to investigate the possible association between Periodontal Disease indices and risk of development Acute Hematopoietic Cancer (Acute Myeloid and Acute Lymphoblastic Leukemia) in a representative Greek adult sample. 174 individuals with Acute Myeloid and Acute Lymphoblastic Leukemia-cases and 174 matched healthy individuals- controls underwent an oral and dental clinical examination and completed a questionnaire. The periodontal condition for cases and controls included Probing Pocket Depth (PPD), Clinical Attachment Loss (CAL) and Gingival Index (GI). Chi-square test and logistic regression models were carried out to assess the possible association. The logistic regression model showed that CAL (p= 0.054) (OR= 2.467, 95% CI= 1.177-2.231), and GI (p= 0.043) (OR = 3.352, 95% CI= 1.285-4.745), were marginally significantly associated with an increased risk of developing Acute Hematopoietic Cancer.

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Section: Discussionmentioning

confidence: 99%

Investigation of the Association between Periodontal Disease Indices and Risk of Acute Hematopoietic Cancer Development (Acute Myeloid and Acute Lymphoblastic Leukemia): A Case – Control Study

Chrysanthakopoulos¹,

Vryzaki²

2022

SJMH

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“…The subgingival biofilms in periodontitis act as gram-negative anaerobic bacteria reservoirs of P. gingivalis and A. actinomycetemcomitans [142], that release enzymes and invade to gingival epithelial cells [143]. Those enzymes and other bacterial components such as endotoxins, and metabolic by-products that are toxic to tissues, may cause direct damage to DNA of the surrounding epithelial cells, or are able to induce mutations in proto-oncogenes and tumor suppressor genes, or interfere with the molecular signaling pathways involved in cell survival and/or proliferation [144]. P. gingivalisis a periopathogenic bacterium that mediates the local inflammatory response of periodontitis [145], interferes with physiological metabolism, invades gingival epithelial cells, and inhibits apoptosis [146], that is a cancer hallmark [147].…”

Section: Chronicmentioning

confidence: 99%

Examination of the Association between Periodontal Disease, Tooth Loss, and Risk of Gallbladder Carcinoma : A Case- Control Study in Greek Adults

Chrysanthakopoulos,

Vryzaki

2024

Arch Dent

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Objective: To estimate the possible association between periodontal disease (PD) clinical indices, and number of missing teeth and the risk of developing gallbladder carcinoma (GBC) in Greek adults using data from a population based case-control study. Material and Method: The study sample comprised 80 males and 67 females, aged 45 to 79 years. 49 individuals suffered from GBC- cases and 98 were healthy individuals - controls. All clinical indices examined were obtained via a modified standardized questionnaire and an oral and dental clinical examination. Periodontal status included the following clinical parameters, probing pocket depth (PPD), gingival index (GI), plaque index (PlI), clinical attachment loss (CAL), and bleeding on probing (BOP), and the number of missing teeth. The questionnaire included data regarding the dependent and independent risk factors for GBC development. Univariate and logistic regression models adjusted for possible confounders were carried out for data analysis. Results: Statistical analysis showed that chronic GB inflammation (p=0.00, OR=2.74, 95% CI=1.28-5.86), smoking (p=0.05, OR=1.63, 95% CI=1.26-2.72), GI (p=0.05, OR=1.56, 95% CI=1.20-2.62), and missing teeth more than four teeth (p=0.03, OR=1.74,95% CI=1.30-3.75, p=0.02, OR= 2.03, 95% CI=1.67-4.11) were statistically significantly associated with the risk of developing GBC. Conclusions: The current research suggested positive associations of chronic inflammation of the gallbladder, smoking, gingival inflammation, and missing teeth more than four with GBC development.

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“…As bactérias causadoras da DP, seus componentes, como endotoxina, e seus subprodutos metabólicos podem causar toxicidade nas células circundantes e desencadear mutações em proto-oncogenes e genes supressores de tumores, por consequência alterar vias de sinalizações envolvidas no mecanismo de proliferação celular 23 . o Porphyromonas gingivalis A P. gingivalis é uma bactéria que coloniza a cavidade oral, sendo encontrada principalmente na placa supragengival.…”

Section: O Doença Periodontal E Câncer De Pâncreasunclassified

A doença periodontal como um fator de risco para o câncer de pâncreas

et al. 2021

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A neoplasia pancreática ganhou destaque por sua alta letalidade e perspectiva de aumento da incidência no mundo, sendo a doença periodontal apontada como um dos fatores de risco para o desenvolvimento dessa patologia. Os patógenos encontrados na doença periodontal, como a Porphyromonas gingivalis e a Helicobacter pylori desencadeiam uma resposta inflamatória no hospedeiro que podem promover a carcinogênese pancreática. A resposta condicionada pelos agentes microbianos da doença periodontal, resulta no aumento de marcadores inflamatórios que estão expressos no câncer de pâncreas. De tal modo, esta pesquisa teve como intuito realizar uma revisão de literatura narrativa de estudos que correlacionam o câncer de pâncreas com a Doença Periodontal, tendo as plataformas Google Acadêmico e Scielo (Scientific Eletronic Library Online) como fonte de pesquisa, utilizando os seguintes descritores: “Câncer”, “Câncer de pâncreas” e “Doença periodontal”, durante os meses de Maio e Julho do ano de 2020. Os artigos selecionados foram do ano de 2003 ao ano de 2019. A realização de mais pesquisas sobre essa correlação se faz necessária, para que haja esclarecimento sobre a ligação entre essas doenças.

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The Emerging Concepts on the Impact of Periodontitis on Systemic Health

Cited by 6 publications

References 149 publications

Investigation of the Association between Periodontal Disease Indices and Risk of Acute Hematopoietic Cancer Development (Acute Myeloid and Acute Lymphoblastic Leukemia): A Case – Control Study

Investigation of the Association between Periodontal Disease Indices and Risk of Acute Hematopoietic Cancer Development (Acute Myeloid and Acute Lymphoblastic Leukemia): A Case – Control Study

Examination of the Association between Periodontal Disease, Tooth Loss, and Risk of Gallbladder Carcinoma : A Case- Control Study in Greek Adults

A doença periodontal como um fator de risco para o câncer de pâncreas

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