Association between Oxidative Stress and Outcome in Different Subtypes of Acute Ischemic Stroke

Tsai, Nai‐Wen; Chang, Ya‐Ting; Huang, Chi-Ren; Lin, Yujun; Lin, Wei-Che; Cheng, Ben-Chung; Su, Chih-Min; Chiang, Yu Chung; Chen, Shu-Fang; Huang, Chih-Cheng; Chang, Wen-Neng; Lu, Cheng-Hsien

doi:10.1155/2014/256879

Cited by 49 publications

(40 citation statements)

References 32 publications

(38 reference statements)

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“…Guldiken et al 16 found that circulating oxLDL levels were increased in the patients of acute ischemic stroke. Tsai et al 17 demonstrated that oxidative stress was progressive after ischemic stroke and contributed to further neurological damage. Furthermore, another study revealed that higher plasma oxLDL levels were a predictor for poor prognosis 3 months after acute ischemic stroke, even after adjustments for high-sensitivity C-reactive protein, white blood cell, infarct volume, and other lipid confounders and traditional risk factors for stroke outcome.…”

Section: Discussionmentioning

confidence: 99%

Association of Oxidized Low-Density Lipoprotein With Prognosis of Stroke and Stroke Subtypes

Wang

Yang

et al. 2017

Stroke

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Background and Purpose-The association between oxidized low-density lipoprotein (oxLDL) and the long-term prognosis of stroke is unclear. The aim of this study is to investigate whether oxLDL levels contribute to the prognosis of stroke and stroke subtypes. Methods-All patients with ischemic stroke were recruited from the SOS-Stroke (Study of Oxidative Stress in Patients WithAcute Ischemic Stroke) and classified into 5 different subtypes, according to the TOAST criteria (Trial of Org 10172 in Acute Stroke Treatment). We measured oxLDL levels and followed up with patients at 1 year after stroke onset. We analyzed the association between oxLDL and the clinical outcomes of death and poor functional outcome (modified Rankin Scale score of 3-6) of stroke and different stroke subtypes. Results-Among the 3688 patients included in this study, 293 (7.94%) were deceased at the 1-year follow-up and 1020 (27.66%) had a poor functional outcome. Patients in the highest oxLDL quartile had a higher risk of 1-year stroke mortality (hazard ratio, 1.61; 95% confidence interval, 1.10-2.33; P<0.001) and a poor functional outcome (odds ratio, 1.48; 95% confidence interval, 1.15-1.89; P<0.001) compared with the lowest oxLDL quartile. In the subgroup analyses, oxLDL was only significantly associated with death and poor functional outcome in the large-artery atherosclerosis subgroup (P<0.05) and small-artery occlusion subgroup (P<0.05). Conclusions-High levels of oxLDL were associated with the high risk of death and poor functional outcome within 1 year after stroke onset, especially in large-artery atherosclerosis and small-artery occlusion stroke subtypes. Therefore, in this prospective cohort study, we investigated the associations between oxLDL and the long-term prognosis of stroke and stroke subtypes. Methods Study Design and PopulationThe study population was recruited from the SOS-Stroke (Study on Oxidative Stress in Patients with Acute Ischemic Stroke ), a nationwide multicenter prospective registry. 13 The SOS-Stroke study enrolled 4164 consecutive patients with stroke from 43 designated hospitals in China from January to October 2014. Patients with a diagnosis of acute ischemic stroke within 7 days after the onset of stroke were included in this study. The inclusion criteria for SOSStroke were as follows: (1) age >18 years; (2) diagnosis of acute ischemic stroke by a neurologist and confirmation of such with brain computed tomography or magnetic resonance imaging; (3) time from onset of stroke to diagnosis was <1 week; and (4) the patient provided informed consent. Standard Protocol Approvals, Registrations, and Patient ConsentsThe study was sponsored by the China Stroke Prevention Project of the National Health and Family Planning Commission and was approved by the Ethics Committee of Beijing Tiantan Hospital, Xuanwu Hospital Capital Medical University, and Peking Union Medical College Hospital and was in compliance with the Declaration of Helsinki. All participants provided written informed consent. Baseline Data Collection ...

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Section: Discussionmentioning

confidence: 99%

Association of Oxidized Low-Density Lipoprotein With Prognosis of Stroke and Stroke Subtypes

Wang

Yang

et al. 2017

Stroke

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“…In the current study, the thiol index increased significantly in HS and IS over the first 7 days. Tsai et al (24) reported that the amount of free thiols in acute stroke patients increased by the seventh day to a level similar to that of the control group. Several studies reported that the thiol level in IS patients was significantly lower than in the control (4,24,25).…”

Section: Discussionmentioning

confidence: 82%

“…Tsai et al (24) reported that the amount of free thiols in acute stroke patients increased by the seventh day to a level similar to that of the control group. Several studies reported that the thiol level in IS patients was significantly lower than in the control (4,24,25). Thiols are organic compounds that contain a sulfhydryl (-SH) group that protects against oxidative stress.…”

Section: Discussionmentioning

confidence: 82%

Oxidative Stress and Antioxidant Markers in Serum and Red Blood Cell of Patients with Ischemic and Hemorrhagic Stroke: A Case-Control Study

et al. 2016

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Background and Aim: Oxidative stress is a major mechanism involved in stroke pathogenesis. The present study evaluated and compared oxidative stress parameters in patients with ischemic and hemorrhagic stroke (IS and HS) at the time of hospitalization and 1 week after hospitalization. Methods: This was a case-control study with 87 stroke patients (58 IS and 29 HS) as the case and 58 normal individuals as the control group. Sampling was done at the time of hospitalization and after 1 week. The serum total antioxidant capacity (TAC), thiol group, and F2-isoprostan levels were measured using Ferric Reducing Antioxidant Power (FRAP), Elman, and Enzyme Linked Immunosorbent Assay ELISA methods, respectively. Results: At the time of hospitalization, there was no significant difference in TAC and F2-isoprostan levels between the case and

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“…Previous studies have shown that serum thiol levels are lower in acute ischaemic stroke patients compared to healthy patients; with an increase in the diameter of the arteries causing the ischaemia, thiol levels decrease further [22][23][24]. Patients with lower thiol levels using diff erent neurological assessment scales (NIHSS, mRS and Barthel scale etc.)…”

Section: Discussionmentioning

confidence: 99%

Oxidative injury associated with stenting of asymptomatic carotid artery stenosis

Saraçoğlu

Vuruşkan

Çekici

et al. 2017

Vasa

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Summary:Background: After carotid artery stenting (CAS), neurological complications that cannot be explained with imaging methods may develop. In our study we aimed to show, using oxidative stress markers, isolated oxidative damage and resulting neurological fi ndings following CAS in patients with asymptomatic carotid artery stenosis. Patients and methods: We included 131 neurologically asymptomatic patients requiring CAS. The neurological fi ndings were evaluated using the modifi ed Rankin Scale (mRS) prior to the procedure, one hour post-procedure, and two days after. Patients with elevated mRS scores but with or without typical hyperintense lesions observed on an MRI and with changes of oxidative stress marker levels at the time (Δtotal-thiol, Δtotal antioxidative status [TAS], and Δtotal oxidant status [TOS]) were evaluated. Results: In the neurological examination carried out one hour prior to the procedure, there were 92 patients with mRS = 0, 20 with mRS = 1, and 12 with mRS = 2. When Δtotal-thiol, ΔTAS, and ΔTOS values and the mRS were compared, it was observed that as the difference in oxidative parameters increased, clinical deterioration also increased proportionally (p = 0.001). Conclusions: We demonstrate a possible correlation between oxidative damage and neurological fi ndings after CAS which could not be explained by routine imaging methods. Keywords:Reperfusion injury, carotid artery stenting, oxidative damage, total thiol jor or minor thromboembolism by the imaging modalities after carotid artery stenting, might be the result of reperfusion injuries.Our research aimed at the underlying causes of the development of transient neurological complications that cannot be explained via imaging methods following elective CAS. We tried to show the isolated oxidative damage and the resulting clinical fi ndings following stenting in patients with asymptomatic carotid artery severe stenosis. Patients and methods Patient populationApproval for the study was received from our local ethical board. Between September 2014 and August 2016, we investigated a total of 343 consecutive severe carotid artery stenosis patients who are neurologically asymptomatic (without stroke, transient ischaemic attack or amaurosis fugax events within the previous six months). With the results of interdisciplinary consultation between the neurology and cardiovascular surgery departments, 160 patients were referred for carotid endarterectomy,

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Association between Oxidative Stress and Outcome in Different Subtypes of Acute Ischemic Stroke

Cited by 49 publications

References 32 publications

Association of Oxidized Low-Density Lipoprotein With Prognosis of Stroke and Stroke Subtypes

Association of Oxidized Low-Density Lipoprotein With Prognosis of Stroke and Stroke Subtypes

Oxidative Stress and Antioxidant Markers in Serum and Red Blood Cell of Patients with Ischemic and Hemorrhagic Stroke: A Case-Control Study

Oxidative injury associated with stenting of asymptomatic carotid artery stenosis

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