Association of Oxidized Low-Density Lipoprotein With Prognosis of Stroke and Stroke Subtypes

Wang, Anxin; Yang, Yi; Su, Zhaoping; Yue, Wei; Hao, Hongjun; Ren, Lijie; Wang, Yongjun; Cao, Yibin

doi:10.1161/strokeaha.116.014816

Cited by 45 publications

(37 citation statements)

References 33 publications

(27 reference statements)

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“…Tsai et al [13] revealed that higher oxLDL concentration was a predictor for poor prognosis at 3 months after acute ischaemic stroke. The Study of Oxidative Stress in Patients With Acute Ischemic Stroke (SOS-Stroke) also demonstrated that high levels of oxLDL were associated with high risk of death and poor functional outcome at 1 year after stroke onset [14]. Our study confirmed and extended previous studies.…”

Section: Discussionsupporting

confidence: 89%

Oxidative lipoprotein markers predict poor functional outcome in patients with minor stroke or transient ischaemic attack

Wang

Zhang

et al. 2019

Euro J of Neurology

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Background and purpose Oxidative stress plays an important role in acute ischaemic stroke. However, the association of oxidative lipoprotein markers, including oxidized low‐density lipoprotein (oxLDL), oxLDL:high‐density lipoprotein (HDL) and oxLDL:low‐density lipoprotein (LDL), with functional outcome of minor stroke or transient ischaemic attack (TIA) remains unclear. We aimed to investigate the association between oxidative lipoprotein markers and poor functional outcome in patients with minor stroke or TIA. Methods All patients with minor stroke or TIA were recruited from the Clopidogrel in High‐Risk Patients With Acute Non‐Disabling Cerebrovascular Events (CHANCE) trial. The poor functional outcome included modified Rankin Scale (mRS) score 2–6 and 3–6 at 90‐day and 12‐month follow‐up. Multivariate logistic regression was used to investigate the associations of oxLDL, oxLDL:HDL and oxLDL:LDL with poor functional outcome. Results Among 3019 patients included in this study, the median (interquartile range) oxLDL, oxLDL:HDL and oxLDL:LDL were 13.96 (6.65–28.81), 4.52 (2.08–9.32) and 11.73 (5.27–24.85) μg/dL, respectively. After adjusted for confounding factors, patients in the highest oxLDL quartile had a higher proportion of mRS score 2–6 at 90 days [hazard ratio (HR), 1.78; 95% confidence interval (CI), 1.26–2.52] and 12 months (HR, 1.42; 95% CI, 1.01–1.99), and mRS score 3–6 at 90 days (HR, 1.98; 95% CI, 1.29–3.04) and 12 months (HR, 1.77; 95% CI, 1.09–2.89) when compared with the lowest oxLDL quartile (P < 0.05). Similar results were found for oxLDL:HDL and oxLDL:LDL. Conclusions Higher levels of oxidative lipoprotein markers are independent predictors of poor functional outcome in patients with minor stroke or TIA at 90 days and 12 months.

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Section: Discussionsupporting

confidence: 89%

Oxidative lipoprotein markers predict poor functional outcome in patients with minor stroke or transient ischaemic attack

Wang

Zhang

et al. 2019

Euro J of Neurology

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“…Oxidized low‐density lipoprotein (oxLDL) is a biomarker that is a key factor for the occurrence and development of atherosclerosis and the formation of unstable plaque . Its pathological role in atherosclerosis has been recognized , with oxLDL causing endothelial cell injury and promoting foam cell formation, the proliferation of vascular smooth muscle cells, and platelet adhesion and aggregation, as well as other factors involved in the formation of atherosclerosis . oxLDL has also been designated as an independent risk factor in many acute or chronic inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Association between oxidized low‐density lipoprotein and cognitive impairment in patients with ischemic stroke

Wang¹,

Liu

Meng³

et al. 2017

Euro J of Neurology

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Background and purpose: The association between oxidized low-density lipoprotein (oxLDL) and cognitive impairment is unclear. This study aimed to investigate the potential association between oxLDL and cognitive impairment among patients with acute ischemic stroke. Methods: We measured the levels of oxLDL and recorded the Mini-Mental State Examination (MMSE) score in patients with acute ischemic stroke who were recruited from the Study of Oxidative Stress in Patients with Acute Ischemic Stroke. Cognitive impairment was defined as an MMSE score of <24. The association between oxLDL and cognitive impairment was assessed by multivariate logistic or linear regression analysis. Other clinical variables of interest were also studied. Results: A total of 3726 patients [1287 (34.54%) female] were included in this study, with a mean age of 63.62 AE 11.96 years. After adjusting for potential confounders in our logistic regression model, each SD increase in oxLDL was associated with a 26% increase in the prevalence of cognitive impairment (odds radio, 1.26; 95% confidence interval, 1.13-1.39; P < 0.0001). Similarly, higher oxLDL was associated with lower MMSE scores, with a 0.56-point decrease in MMSE score for every SD increase in oxLDL in a linear regression analysis (b = À0.56; 95% confidence interval, À0.81 to À0.32; P < 0.0001). There were no significant interactions between oxLDL and age, sex or education levels for cognitive impairment (all interactions, P > 0.05). Conclusions: Elevated levels of oxLDL were associated with a higher prevalence of cognitive impairment in patients with ischemic stroke.

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“…Several studies have confirmed that LDL‐C and its oxidized form was an independent risk factor of stroke (Cholesterol Treatment Trialists’ (CTT) Collaboration, ; Wang et al., ). In our study, LDL‐C weakly correlated with the outcome of AIS ( p = .038) with an unadjusted OR of 1.377 (95% CI, 1.018–1.865), while, serum sLOX‐1 showed strong relation with clinical prognosis of AIS ( p < .0001) with an adjusted OR of 2.946 (95% CI, 1.788–4.856).…”

Section: Discussionmentioning

confidence: 99%

Role ofsLOX‐1 in intracranial artery stenosis and in predicting long‐term prognosis of acute ischemic stroke

Jin

Xue

et al. 2017

Brain and Behavior

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ObjectiveThe role of sLOX‐1 in acute ischemic stroke still remains unclear. This study aims to demonstrate the value of sLOX‐1 in evaluating degrees of intracranial artery stenosis and to predict prognosis in stroke.MethodsTwo hundred and seventy‐two patients were included in this study and basic data were collected within 72 hr on admission. We assessed the association between sLOX‐1 levels and stroke conditions in one‐year duration. After adjusting for potential confounders, regression analyses were performed.ResultsWe found that sLOX‐1 levels were increased significantly in severe patients compared to the mild stroke group (p = .011). After adjusting confounders, sLOX‐1 was associated with a poor functional outcome in patients with an adjusted OR of 2. 946 (95% CI, 1.788–4.856, p < .001). There was also positive correlation between sLOX‐1 levels and the degrees of intracranial artery stenosis in the different groups (p = .029).ConclusionsOur study demonstrated that sLOX‐1 levels could be used to evaluate the severity of stroke and the degrees of intracranial artery stenosis. Furthermore, sLOX‐1 could be exploited to predict the long‐term functional outcome of stroke.

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Association of Oxidized Low-Density Lipoprotein With Prognosis of Stroke and Stroke Subtypes

Cited by 45 publications

References 33 publications

Oxidative lipoprotein markers predict poor functional outcome in patients with minor stroke or transient ischaemic attack

Oxidative lipoprotein markers predict poor functional outcome in patients with minor stroke or transient ischaemic attack

Association between oxidized low‐density lipoprotein and cognitive impairment in patients with ischemic stroke

Role ofsLOX‐1 in intracranial artery stenosis and in predicting long‐term prognosis of acute ischemic stroke

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