Association between overweight/obesity and periodontitis in adults. A systematic review

Abstract

SummaryOverweight and obesity have been suggested to be associated with periodontitis as published in studies and narrative summaries. This project presents results of a systematic review investigating the association between overweight or obesity (as defined by the World Health Organization) and periodontitis.Search strategy included electronic and hand searching to December 2009. Ovid MEDLINE, EMBASE, LILACS, and SIGLE were searched. RCTs, cohort, casecontrol and cross-sectional study designs that included measures of periodontitis and body composition were eligible. Duplicate, independent screening and data abstraction were performed. Meta-analyses were performed when appropriate.A total of 526 titles and abstracts were screened, resulting in 61 full text articles and abstracts assessed for eligibility with 33 being included. Nineteen studies provided sufficient information for inclusion in meta-analyses. Meta-analyses indicated statistically significant associations between periodontitis and body mass index (BMI) category obese OR 1.81(1.42, 2.30), overweight OR 1.27(1.06, 1.51) and obese and overweight combined OR 2.13(1.40, 3.26).In conclusion, these results support an association between BMI overweight and obesity and periodontitis although the magnitude is unclear. Additional prospective studies to further quantify, or understand the mechanisms, of this association are merited. There is insufficient evidence to provide guidelines to clinicians on the clinical management of periodontitis in overweight and obese individuals.

Upregulation of Gingival Tissue miR-200b in Obese Periodontitis Subjects

“…Obesity is associated with a higher prevalence of periodontitis where adipocytes surpass their lipid storage role and exert a number of endocrine functions, resulting in a state of lowgrade inflammation and insulin resistance (Suvan et al 2011). This may explain the more severe clinical presentation of periodontitis before treatment and poor response to periodontal therapy with less pocket resolution and higher bleeding levels (Suvan et al 2014).…”

Interleukin-34 Levels in Gingival Crevicular Fluid and Plasma in Healthy and Diseased Periodontal Tissue in Presence or Absence of Obesity: A Clinico-biochemical Study

“…Obesity plays a role in modulating the initiation and progression of periodontal disease. Recent meta-analyses have validated a positive association between being overweight or obese and periodontitis 6,14,27) .…”

Phylogenetic and functional gene structure shifts of the oral microbiomes in periodontitis patients

“…Periodontitis is the leading cause of tooth loss worldwide (Petersen et al, 2005;Pihlstrom et al, 2005). Furthermore, it has been proven to be a significant risk factor of systematic diseases, including coronary heart disease (Dietrich et al, 2008), stroke (Sfyroeras et al, 2012), obesity (Suvan et al, 2011), atherosclerosis (Tonetti, 2009), preterm birth and low birth weight in infants (Rakoto-Alson et al, 2009).…”