Phylogenetic and functional gene structure shifts of the oral microbiomes in periodontitis patients

Li, Yan; He, Jinzhi; He, Zhili; Zhou, Yuan; Yuan, Mengting; Xu, Xin; Sun, Feifei; Liu, Chengcheng; Li, Jiyao; Xie, Wenbo; Deng, Ye; Qin, Yujia; VanNostrand, Joy D.; Xiao, Liying; Wu, Liyou; Zhou, Jizhong; Shi, Wenyuan; Zhou, Xuedong

doi:10.1038/ismej.2014.28

Cited by 146 publications

(145 citation statements)

References 66 publications

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“…These findings agree with those from Davis et al (2013), where Firmicutes were found to be the most abundant in mild periodontitis and also with surveys of human plaque where higher proportions of Spirochetes, Synergistetes and Firmicutes were observed in periodontitis (Abusleme et al, 2013;Li et al, 2014). Another human study by Griffen et al (2012) confirmed associations with periodontitis for the red-complex species Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia (Socransky et al, 1998) along with other species such as Filifactor alocis.…”

Section: Bacterial Species Associated With Evolution To Periodontitissupporting

confidence: 86%

A longitudinal assessment of changes in bacterial community composition associated with the development of periodontal disease in dogs

Wallis¹,

Marshall²,

Colyer³

et al. 2015

Veterinary Microbiology

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Periodontal disease is the most widespread oral disease in dogs. Whilst the involvement of bacteria in the aetiology of periodontitis is well established the role of individual species and their complex interactions with the host is not well understood. The objective of this research was therefore to perform a longitudinal study in dogs to identify the changes that occur in subgingival bacterial communities during the transition from mild gingivitis to the early stages of periodontitis (<25% attachment loss). Subgingival plaque samples were collected from individual teeth of 52 miniature schnauzer dogs every six weeks for up to 60 weeks. The microbial composition of plaque samples was determined using 454-pyrosequencing of the 16S rDNA. A group of aerobic Gram negative species, including Bergeyella zoohelcum COT-186, Moraxella sp. COT-017, Pasteurellaceae sp. COT-080, and Neisseria shayeganii COT-090 decreased in proportion as teeth progressed to mild periodontitis. In contrast, there was less evidence that increases in the proportion of individual species were associated with the onset of periodontitis, although a number of species (particularly members of the Firmicutes) became more abundant as gingivitis severity increased. There were small increases in Shannon diversity, suggesting that plaque community membership remains relatively stable but that bacterial proportions change during progression into periodontitis. This is the first study to demonstrate the temporal dynamics of the canine oral microbiota; it showed that periodontitis results from a microbial succession predominantly characterised by a reduction of previously abundant, health associated taxa.

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Section: Bacterial Species Associated With Evolution To Periodontitissupporting

confidence: 86%

A longitudinal assessment of changes in bacterial community composition associated with the development of periodontal disease in dogs

Wallis¹,

Marshall²,

Colyer³

et al. 2015

Veterinary Microbiology

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“…In the present study, we did not seek to address the similarity (or otherwise) of the microbiota of teeth and dental implants. However, the dominant bacterial taxa in the plaque in peri-implant sites were similar to those of teeth (Figure S2)3536. We assumed that progression of a healthy implant to PI was similar to the development of periodontitis, and, in this preliminary study, we aimed to identify potential “key pathogens” of peri-implant diseases, which may be less abundant in health.…”

Section: Discussionmentioning

confidence: 96%

Subgingival microbiome in patients with healthy and ailing dental implants

Zheng

Wang

et al. 2015

Sci Rep

129

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Dental implants are commonly used to replace missing teeth. However, the dysbiotic polymicrobial communities of peri-implant sites are responsible for peri-implant diseases, such as peri-implant mucositis and peri-implantitis. In this study, we analyzed the microbial characteristics of oral plaque from peri-implant pockets or sulci of healthy implants (n = 10), peri-implant mucositis (n = 8) and peri-implantitis (n = 6) sites using pyrosequencing of the 16S rRNA gene. An increase in microbial diversity was observed in subgingival sites of ailing implants, compared with healthy implants. Microbial co-occurrence analysis revealed that periodontal pathogens, such as Porphyromonas gingivalis, Tannerella forsythia, and Prevotella intermedia, were clustered into modules in the peri-implant mucositis network. Putative pathogens associated with peri-implantitis were present at a moderate relative abundance in peri-implant mucositis, suggesting that peri-implant mucositis an important early transitional phase during the development of peri-implantitis. Furthermore, the relative abundance of Eubacterium was increased at peri-implantitis locations, and co-occurrence analysis revealed that Eubacterium minutum was correlated with Prevotella intermedia in peri-implantitis sites, which suggests the association of Eubacterium with peri-implantitis. This study indicates that periodontal pathogens may play important roles in the shifting of healthy implant status to peri-implant disease.

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“…fatty acid metabolism and acetyl-coenzyme A degradation, aromatic amino acid degradation, ferrodoxin oxidation, and energy-coupling factor (ECF) class transporters) [42]. Enrichment in the metagenome of genes involved in virulence factors, amino acid metabolism and glycosaminoglycan and pyrimidine degradation in periodontitis, suggest their potential importance in periodontal pathogenesis, while genes involved in amino acid synthesis and pyrimidine synthesis are present at significantly lower relative abundance compared with healthy group [46]. …”

Section: Beyond Community Composition the Functional Role Of Thementioning

confidence: 99%

Beyond microbial community composition: functional activities of the oral microbiome in health and disease

Duran-Pinedo¹,

Frias-Lopez

2015

Microbes and Infection

141

107

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The oral microbiome plays a relevant role in the health status of the host and is a key element in a variety of oral and non-oral diseases. Despite advances in our knowledge of changes in microbial composition associated with different health conditions the functional aspects of the oral microbiome that lead to dysbiosis remain for the most part unknown. In this review, we discuss the progress made towards understanding the functional role of the oral microbiome in health and disease and how novel technologies are expanding our knowledge on this subject.

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Phylogenetic and functional gene structure shifts of the oral microbiomes in periodontitis patients

Cited by 146 publications

References 66 publications

A longitudinal assessment of changes in bacterial community composition associated with the development of periodontal disease in dogs

A longitudinal assessment of changes in bacterial community composition associated with the development of periodontal disease in dogs

Subgingival microbiome in patients with healthy and ailing dental implants

Beyond microbial community composition: functional activities of the oral microbiome in health and disease

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