Association between microRNA polymorphisms and coronary heart disease

Xie, Xiaochuan; Shi, Xiaohan; Xun, Xiaoshuang; Li, Rao

doi:10.1007/s00059-016-4495-4

Cited by 13 publications

(8 citation statements)

References 28 publications

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“…That affected the expression of mature miRNA-146a in CAD patients 49 . That finding was confirmed by Wang et al and showed, that C allele was greater than G allele in gene that predisposed individuals to CAD 50,51 . However, in type 2 diabetes patients with ischemic stroke, the miR-146a was downregulated ( Table 1) 52 .…”

Section: Mutation In the Mrna 3' Utr-regionsupporting

confidence: 54%

Pre-diagnostic role of platelet miRNA in coronary heart disease of healthy overweight subjects via platelet leptin receptor activation

et al. 2019

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Obesity and overweight have become a global problem that development of various coronary artery diseases (CAD), such as myocardial infarction, atherosclerosis and congestive heart failure. Effective diagnosis is needed for effective treatment and prevention, particularly in healthy overweight subject. Platelets is an important component of hemostatic balance, that maintains the coagulation physiology. Platelets are involved in different pathological events such as thrombosis and CAD in various inflammatory conditions. There are evidences that highlight an important role of miRNA in regulation of gene expression profiling in platelets. Current hypothesis has shown the likelihood of using miRNAs as diagnostic markers in the event of CAD. This review article describes the association between overweight/obesity and platelets activation in elucidating the gene expression profiling in platelet miRNAs in CAD patient. The application of platelet miRNAs as predictive markers in overweight/obese individuals may become a marginal milestone in the history of this diet-related disorder treatment.

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Section: Mutation In the Mrna 3' Utr-regionsupporting

confidence: 54%

Pre-diagnostic role of platelet miRNA in coronary heart disease of healthy overweight subjects via platelet leptin receptor activation

et al. 2019

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“…This SNP was studied widely, and many researchers have shown that the G allele of rs2910164 decreased the risk of CAD by downregulating the expression of miR-146a [11,12,21,22]. Excitingly, we got the same results and the G allele frequency (43.4%) in our study was similar to other research [12]. Therefore, we can assume that our sampling data is representative, and results are reliable since we duplicate the results of others.…”

Section: Discussionmentioning

confidence: 99%

“…rs2910164 (C > G) is another common mutation site of miR-146a, and it may alter the function and expression of miRNA [11]. The relationship between rs2910164 and CAD has been studied widely [11,12,13], but results were inconsistent. The purpose of this study is to evaluate the association between two SNPs (rs2431697 and rs2910164) of miR-146a and the risk of CAD in the Chinese population.…”

Section: Introductionmentioning

confidence: 99%

Two Single Nucleotide Polymorphisms (rs2431697 and rs2910164) of miR-146a Are Associated with Risk of Coronary Artery Disease

Wang

et al. 2017

IJERPH

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The coronary artery disease (CAD) is one of the most severe cardiovascular diseases. MicroRNA-146a (miR-146a) influences the pathology of cardiovascular diseases. Two single nucleotide polymorphisms (SNPs) of miR-146a (rs2431697 and rs2910164) have been reported to alter the function or expression of microRNA. The purpose of this study is to evaluate the association between miR-146a gene polymorphism and the risk of CAD in the Chinese population. A total of 353 CAD patients and 368 controls were recruited, and SNPs were analyzed by the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and Sequenom MassARRAY system. The gene frequencies of rs2431697 and rs2910164 were significantly different between the two groups. The mutant type (T allele) of rs2431697 and wild type (C allele) of rs2910164 were more frequent in CAD patients. T allele carriers in rs2431697 had an increased CAD risk, while G allele of rs2910164 decreased the risk of CAD significantly. In conclusion, we found that the T allele of rs2431697 was a risk factor of CAD in the Chinese population. Meanwhile, we demonstrated that the G allele of rs2910164 decreased the susceptibility of CAD.

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“…There are many studies on the potential biomarker value of miRs in the diagnosis of CHD, and the results are inconsistent, as some of them even contradict each other. [19][20][21] In the present study, we screened the differentially expressed miRs from 66 patients with CHD and 58 healthy controls. According to the microarray data, 16 kinds of miRs were selected as the research objects.…”

Section: Discussionmentioning

confidence: 99%

Elevated serum miR‐3129‐5p contributes to the progression of coronary heart disease via targeting mTOR

Wang

Zhao

Zhou

et al. 2020

The Kaohsiung J of Med Scie

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The current study aims to explore the miRNA changes that occur in the serum of patients with coronary heart disease (CHD) and healthy controls using a microarray technique, thereby exploring the potential biomarkers in the diagnosis of CHD and the underlying mechanism. Clinical data were reviewed, and venous blood samples were collected from 66 cases of CHD and 58 cases of healthy controls. MicroRNAwide expression profiling identified 16 miRNAs that were aberrantly decreased bỹ 2-fold in the serum of patients with CHD compared to that of healthy controls. RT-PCR analysis indicated that the expression of miR-3129-5p was increased the most in patients with CHD compared with that of controls. Moreover, serum miR-3129-5p was found to be highest in the severe stenosis group, followed by the moderate stenosis group and mild stenosis group. ROC analysis showed that serum miR-3129-5p could differentiate patients with CHD from controls. Further study showed that mTOR was a target gene of miR-3129-5p. Western blot assays demonstrated that miR-3129-5p significantly suppressed the phosphorylation of S6 but increased LC3II/LC3I and Beclin1 levels. Consistently, GFP-LC3 and TEM assays indicated that miR-3129 increased autophagy puncta in H9C2 cells. More importantly, silencing mTOR significantly decreased the expression of p-S6 but increased LC3II/LC3I and Beclin expression even in H9C2 cells transfected with miR-3129-5p inhibitor, indicating that miR-3129-5p-induced cell autophagy was mediated via mTOR in H9C2 cells. In summary, elevated serum miR-3129-5p contributes to CHD by targeting mTOR signaling and may be a therapeutic target in the treatment of CHD.

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Association between microRNA polymorphisms and coronary heart disease

Cited by 13 publications

References 28 publications

Pre-diagnostic role of platelet miRNA in coronary heart disease of healthy overweight subjects via platelet leptin receptor activation

Pre-diagnostic role of platelet miRNA in coronary heart disease of healthy overweight subjects via platelet leptin receptor activation

Two Single Nucleotide Polymorphisms (rs2431697 and rs2910164) of miR-146a Are Associated with Risk of Coronary Artery Disease

Elevated serum miR‐3129‐5p contributes to the progression of coronary heart disease via targeting mTOR

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