for supercapacitors. [1] However, toward this end the low conductivity nature and random orientation are two main obstacles for MOFs to overcome. Much efforts have been devoted into meeting challenges of the orientation and conductivity issues of MOFs, [2][3][4] the delicate addressing of which can lead to packaging performance enhancement in supercapacitors. [5] Using templates for epitaxial growth of MOF is an easy way to shape the orientation. [4] When it turns to electrochemical energy storage applications like supercapacitor, not only the conductivity of active materials, but the conductivity of the substrate as one part on the electrode can largely influence the overall performance. Sheberla and co-workers have successfully synthesized a conductive MOF for stable supercapacitors. [2] The rectangle cyclic voltammetry (CV) curve of this conductive MOF reveals that the inherent pseudocapacitive sites are not utilized. Recently, a Co-based MOF with conductive network frames was synthesized by Wei and co-workers, which showed promising properties. [6] Stimulated by these promising issues, it is the imperative direction to fabricate a hybrid supercapacitor that delivers a considerable energy density to battery and simultaneously maintain its high power density. To that end, oriented MOFs that can wield potential pseudocapacitance instead of being prepared in powder form on highly conductive substrate may be the best choice. To generate oriented MOF, templates are required, but the template removal procedure needs to be delicate, which may unavoidably trigger MOF deformation or even structural destruction.Affording the unrivalled flexibility to construct topologies and tune sizes or constituents, [7] MOFs have proved themselves versatile in electrochemical energy storage field. [8,9] So it is one common method with easy-manipulation and high efficiency to scarify MOFs as templates or precursors to synthesize target products like metal oxides, [8,10] metal hydroxides, [11] and carbon materials [12] with desired properties. The sacrifice process of MOFs is like DNA pairing, which assures those target products the conformal transformation and preserves pore structures and specific area from raw MOFs. It inspires us by the reverse thinking that: could it be possible to use target products as the Metal organic frameworks (MOFs) are considered as promising candidates for supercapacitors because of high specific area and potential redox sites. However, their shuffled orientations and low conductivity nature lead to severely-degraded performance. Designing an accessibly-manipulated and efficient method to address those issues is of outmost significance for MOF application in supercapacitors. It is the common way that MOFs scarify themselves as templates or precursors to prepare target products. But to reversely think it, using target products to prepare MOF could be the way to unlock the bottleneck of MOFs' performance in supercapacitors. Herein, a novel strategy using Co(OH) 2 as both the template and precursor to fab...

fluorinated solvent and additives. [5] Assisted with solid electrolyte interface (SEI)-forming additives allows for a stable cycling performance with a high Coulombic efficiency, as the negative electrode is protected from co-intercalation reactions of relatively large pyrrolidinium cations. [6] Nevertheless, slow electrode kinetics relating to Li intercalation/de-intercalation and notorious safety issue have been becoming the very bottleneck in improving power densities of these dual-ion batteries while achieving high energy density.To address the problem of low power density for dual-ion batteries, the electrochemical intercalation must be replaced, at least for one electrode, with means of physical adsorption. Accordingly, the electrodes must be abundant with a high specific area and excellent mechanical properties, e.g., graphene and few-layer graphite. [7] Without considering the desolvation/ dendrite issues for Li ions during the fast charge/discharge, the cations in electrolyte absorbing/desorbing onto a graphene surface can supply a high power density. Herein, we propose a dual-ion battery by selecting an electrolyte of (EMIm) + (PF 6 ) − ionic liquid using graphite as positive and reduced graphene oxide (RGO) as negative electrodes. The power density yields as high as 1333 W kg −1 , by simultaneously maintaining a competitive energy density of 70 Wh kg −1 (see Figure 1). The manifested harvesting of optimum performance excels as integration of an intercalation/de-intercalation mechanism and a fast surface absorption/desorption mechanism in a cell. Figure 2A shows the cyclic voltammetry (CV) curve of the graphite electrode at a scan rate of 5 mV s −1 . Although metallic lithium is usually used as the reference electrode or symmetry system without reference electrode, [8] herein the influence of interaction between Li and working electrode was excluded, as well as the complex reactions between two working electrodes. [5] This configuration thereof guarantees liable electrochemical characterization. As indicated by the arrows, a broad peak (1.6-2.0 V) and a small peak (1.46-1.6 V) appear with the potential increasing, unraveling a PF 6 − insertion process. Whereas the potential shifts negatively, two broad and small peaks ranging from 2.0 to 0.8 V were observed, revealing the de-insertion of anions from the graphite electrode. The occurrence of these redox peaks for ion uptaking and releasing in the CV curve describes a stage formation mechanism, in which multiple coordination possibilities exist for the anion in the graphite. These staging effects are well accepted for electrochemical lithium insertion into graphite and for TFSI − into graphitic carbons. [9] It is noted that the peak potential range of the charge process is narrower than that of the discharge process. The main peak in the charge process is consistent with a large current, whereas the curve of the discharge process consists For an electrochemical energy storage cell, it is challenging to synergistically harvest high energy density and hig...

The roles of genetic polymorphisms in the pathogenesis of recurrent miscarriage (RM) have been intensively studied. However, the results of these studies were inconsistent, especially when conducted in different populations. Therefore, we performed the current study to systematically review the broad spectrum of genetic polymorphisms that were suspected to be involved in RM, and discussed potential genetic biomarkers of RM. Eligible articles were identified in PubMed, Medline, Embase and CNKI. Odd ratios (ORs) and 95% confidence intervals (CIs) were used to describe the strength of association, and a probability value (p value) of 0.05 or less was considered as statistically significant. A total of 425 eligible articles were included in this systematic review and 369 articles evaluating 124 polymorphisms of 73 genes were meta-analyzed. Significant associations were found between RM and 53 genetic polymorphisms of 37 genes. Our findings suggest that genetic variants of

In article number https://doi.org/10.1002/aenm.201702294, Wei Zhang, Weitao Zheng and co‐workers suggest a novel strategy to use the common method in reverse, to synthesize a highly‐oriented MOF electrode by using Co(OH)2 as both the template and precursor. As a result, the constituted supercapacitor can deliver a maximum energy density of 28.5 W h kg−1 and a maximum power density of 24000 W kg−1. This inverted design also opens the chemistry gateway for mutual transformations between MOFs and their routine target products.

Our findings suggest that IRS-1 Gly972Arg polymorphism is associated with PCOS in the Caucasian ethnicity, and IRS-2 Gly1057Asp polymorphism is correlated with PCOS in the Asian ethnicity. However, INSR His 1058 C/T polymorphism may not be implicated in PCOS. © 2016 Japan Society of Obstetrics and Gynecology.

Metal oxides as electrode materials are of great potential for rechargeable aqueous batteries. However, they suffer from inferior cycle stability and rate capability because of poor electronic and ionic conductivities. Herein, taking vertically orientated Bi 2 O 3 nanoflakes on Ti substrates as examples, we find that the δ-Bi 2 O 3 electrode with plenty of positively charged oxygen defects show remarkably higher specific capacity (264 mA h g −1 ) and far superior rate capability than that of α-Bi 2 O 3 with less oxygen vacancies. Through pinpointing the existence form and the role of oxygen vacancies within the electrochemical processes, we demonstrate that oxygen vacancies in δ-Bi 2 O 3 can not only promote electrical conductivity but also serve as central entrepots collecting OH − groups via electrostatic force effect, which has boosted the oxidation reaction and enhanced the electrochemical properties. Our work merits an excellent Bi 2 O 3 negative electrode material via giving full play to the role of oxygen vacancies in electrochemical energy storage.

Recently, the roles of toll like receptor (TLR) gene polymorphisms in atherosclerotic diseases were extensively investigated, with conflicting results. Therefore, we performed this study to better assess the relationship between TLR gene variants and atherosclerosis. Eligible studies were searched in PubMed, MEDLINE, EMBASE, Web of Science and CNKI. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate associations between TLR gene polymorphisms and atherosclerosis. A total of 40 studies covering 19,657 cases and 15,660 controls were finally included in our systematic review and meta-analysis. Significant correlations with atherosclerosis susceptibility were found for the TLR1 rs5743551 polymorphism (dominant model: 95% CI 1.03-1.79; recessive model: 95% CI 0.28-0.97; allele model: 95% CI 1.07-1.69), TLR1 rs5743611 polymorphism (dominant model: 95% CI 0.56-0.98) and TLR6 rs5743810 polymorphism (recessive model: 95% CI 0.56-0.92) in overall analyses. Moreover, further subgroup analyses revealed that TLR4 rs1927911 polymorphism was significantly associated with the risk of cerebral infarction in the recessive model (95% CI 0.46-0.96), whereas TLR4 rs4986791 polymorphism was significantly correlated with susceptibility to atherosclerosis among Asians in the dominant (95% CI 1.58-6.66), additive (95% CI 0.13-0.69) and allele (95% CI 1.58-5.53) models. However, no positive results were found for the other 13 TLR polymorphisms. In conclusion, our findings indicate that most TLR gene polymorphisms may not be implicated in the pathogenesis of atherosclerosis, whereas certain TLR gene variations, such as rs5743551, rs5743611, rs5743810, rs4986791 and rs1927911, may serve as genetic biomarkers of atherosclerotic diseases.

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