Maternal genetic polymorphisms and unexplained recurrent miscarriage: a systematic review and meta‐analysis

Abstract

The roles of genetic polymorphisms in the pathogenesis of recurrent miscarriage (RM) have been intensively studied. However, the results of these studies were inconsistent, especially when conducted in different populations. Therefore, we performed the current study to systematically review the broad spectrum of genetic polymorphisms that were suspected to be involved in RM, and discussed potential genetic biomarkers of RM. Eligible articles were identified in PubMed, Medline, Embase and CNKI. Odd ratios (ORs) and 95% confidence intervals (CIs) were used to describe the strength of association, and a probability value (p value) of 0.05 or less was considered as statistically significant. A total of 425 eligible articles were included in this systematic review and 369 articles evaluating 124 polymorphisms of 73 genes were meta-analyzed. Significant associations were found between RM and 53 genetic polymorphisms of 37 genes. Our findings suggest that genetic variants of

Recurrent pregnancy loss: current perspectives

“…However, all the associations were modest, and none reached strong epidemiologic credibility 116. Another meta-analysis using different criteria found significant associations with 53 genetic polymorphisms of 37 genes 117. Interleukin genes are the most commonly associated with RPL, especially IL-1β, IL-6, IL-10, and IL-18 116–118.…”

Genetic association between HLA-G 14-bp polymorphism and diseases: A systematic review and meta-analysis

“…Despite of the influence of the 14-bp fragment on gene expression, results are still considered inconclusive. Since all meta-analyses regarding the association between the 14-bp polymorphism have focused on particular diseases [14][15][16][17][18][19][20][21][22] or on a limited group of diseases [23][24][25], in this study we performed a systematic review of the literature followed by a meta-analysis of all association studies already published for the 14-bp polymorphism in several disorders, stratified according to groups of similar disorders, specific disorders, and even grouping disorders according to the putative beneficial or detrimental effect of the HLA-G expression.…”

Are leptin and adiponectin involved in recurrent pregnancy loss?

“…It has been suggested that poor pregnancy outcomes are linked to genetic polymorphisms . For example, several polymorphisms of the TNFα gene might have a role in the pathogenesis of RPL.…”