Association between lysyl oxidase polymorphisms and oral submucous fibrosis in older male areca chewers

Shieh, Tzong‐Ming; Tu, His-Feng; Ku, Ti-Hsuan; Chang, Shu-Shin; Chang, Kuo‐Wei; Liu, Chung Ji

doi:10.1111/j.1600-0714.2008.00695.x

Cited by 28 publications

(26 citation statements)

References 33 publications

(49 reference statements)

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“…66 Copper dependant enzyme lysyl oxidase is critical for collagen cross linking and organization of ECM. 67 Salivary copper is found to be higher in arecanut chewers. This finding indicates that soluble copper found in arecanut is released into the oral environment and its buccal absorption may contribute to fibrosis of oral tissues where copper is deposited.…”

Section: Copper and Related Structural Changes Of Collagenmentioning

confidence: 97%

Oral submucous fibrosis: a historical perspective and a review on etiology and pathogenesis

Tilakaratne

Ekanayaka

Warnakulasuriya

2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

143

126

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Section: Copper and Related Structural Changes Of Collagenmentioning

confidence: 97%

Oral submucous fibrosis: a historical perspective and a review on etiology and pathogenesis

Tilakaratne

Ekanayaka

Warnakulasuriya

2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

143

126

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“…The incidence rate of oral squamous cell carcinoma in patients with OSF, after a follow-up period of 17 years, has been estimated to be 7.6% (2). Areca-associated oral squamous cell carcinoma is the third most common malignancy in the developing world (3). Despite the fact that OSF is, at times, preceded by and/or linked to vesicle formation, it is known to be associated with a juxta-epithelial inflammatory reaction, which is followed by a fibroelastic change of the lamina propria, with epithelial atrophy resulting in stiffness of the oral mucosa and causing inability to eat and trismus (4).…”

Section: Introductionmentioning

confidence: 99%

Autophagy mediates oral submucous fibrosis

Jiang

Zhao

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Oral submucous fibrosis (OSF) is a chronic insidious disease of the oral mucosa, well-recognized as a premalignant condition and commonly found in Southern China. It is primarily caused by the habit of areca nut or gutkha chewing. OSF is believed to be a homeostatic disorder of the extracellular matrix and fibroblast proliferation. The present study demonstrated a novel link between autophagy and OSF. Tissue samples from human OSF showed an overexpression of the autophagy marker microtubule-associated protein 1 light chain 3 using immunohistochemistry and quantitative polymerase chain reaction. With regard to the crucial role of transforming growth factor (TGF)-β in OSF disease, western blot analysis demonstrated that TGF-β signaling was shown to contribute to the activation of autophagy in fibroblasts in vitro; however, a cell apoptosis and MTS assay demonstrated that the suppression of autophagy ameliorated the fibrosis induced by active TGF-β receptor type I signaling, as well as promoted fibroblast apoptosis and suppressed proliferation. Therefore, the present results suggest that autophagy serves a crucial function in OSF.

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“…As a result, LOX Arg158Gln could affect PCP cleaving efficiency and reduce the availability of the LOX active form. Recently, an association has been described between the G473A polymorphism and oral submucous fibrosis (a lesion characterized by fibrosis of the oral submucosa and the progressive tissue rigidity) in South Asian older males chewing areca nuts (62). Therefore, the possibility that LOX-dependent cardiac fibrosis is genetically determined requires further investigation.…”

Section: Role Of Lox In Myocardial Fibrosismentioning

confidence: 99%

Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects

López

González

Hermida

et al. 2010

American Journal of Physiology-Heart and Circulatory Physiology

221

198

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Because of its dynamic nature, the composition and structure of the myocardial collagen network can be reversibly modified to adapt to transient cardiac injuries. In response to persistent injury, however, irreversible, maladaptive changes of the network occur leading to fibrosis, mostly characterized by the excessive interstitial and perivascular deposition of collagen types I and III fibers. It is now becoming apparent that myocardial fibrosis directly contributes to adverse myocardial remodeling and the resulting alterations of left ventricular (LV) anatomy and function present in the major types of cardiac diseases. The enzyme lysyl oxidase (LOX) is a copper-dependent extracellular enzyme that catalyzes lysine-derived cross-links in collagen and elastin. LOXmediated cross-linking of collagen types I and III fibrils leads to the formation of stiff collagen types I and III fibers and their subsequent tissue deposition. Evidence from experimental and clinical studies shows that the excess of LOX is associated with an increased collagen cross-linking and stiffness. It is thus conceivable that LOX upregulation and/or overactivity could underlie myocardial fibrosis and altered LV mechanics and contribute to the compromise of LV function in cardiac diseases. This review will consider the molecular aspects related to the regulation and actions of LOX, namely, in the context of collagen synthesis. In addition, it will address the information related to the role of myocardial LOX in heart failure and the potential benefits of controlling its expression and function. collagen; diastolic dysfunction; hypertensive heart disease; myocardial remodeling THE ELEVATION IN myocardial stress that results from cardiac injury and/or persistent elevations in ventricular pressure or volume triggers a response of the myocardium in an attempt to return the tissue stress to its normal value. This response leads to progressive structural remodeling of the cardiomyocyte, vascular and extracellular matrix (ECM) components of the myocardium that manifest as changes in ventricular wall and chamber dimensions, as well as in diastolic and systolic function (5).Alterations in the myocardial collagen network are a hallmark of the ECM response to stress, either hemodynamic or nonhemodynamic in origin. A collagen network, composed largely of collagen types I and III fibers, is found in the interstitial space of the myocardium. Because collagen is a relatively stiff material with a high-tensile strength, small changes in its concentration have been shown to exert marked effects on the passive mechanical properties of the human heart (7). In addition to the concentration of collagen, experimental data suggest that the passive behavior of the myocardium may also be dependent on the relative proportion of the types of collagen, the diameter of the collagen fibers and their spatial alignment, and the degree of cross-linking. Accordingly, tissue containing predominantly type I collagen, large-diameter collagen fibers, and/or a high degree of cross-lin...

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Association between lysyl oxidase polymorphisms and oral submucous fibrosis in older male areca chewers

Abstract: The elder OSF patients were increased in LOX Arg158Gln. Our findings may suggest a potential application in risk population selection using LOX polymorphism for preventive intervention of OSF genesis in a subset of areca chewers.

Cited by 28 publications

References 33 publications

Oral submucous fibrosis: a historical perspective and a review on etiology and pathogenesis

Oral submucous fibrosis: a historical perspective and a review on etiology and pathogenesis

Autophagy mediates oral submucous fibrosis

Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects

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