Oral submucous fibrosis: a historical perspective and a review on etiology and pathogenesis

Tilakaratne, Wanninayake Mudiyanselage; Ekanayaka, Rasika Priyadharshani; Warnakulasuriya, Saman

doi:10.1016/j.oooo.2016.04.003

Cited by 143 publications

(141 citation statements)

References 78 publications

(52 reference statements)

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“…Patients with bigger ulceroproliferative lesions with mandibular invasion were more worried about the shear presentation than anything else. In most of the studies associated oral submucosal fibrosis is more troublesome than the lesion per se and tumor is incidentally detected in these groups of patients [4]. Pain and trismus was the second most common complaint, which can be present because of the lesion proper on submucosal fibrosis, these patients would usually complain of burning sensation and poor tolerance to spicy food.…”

Section: Discussionmentioning

confidence: 99%

Indian cancer: Our experience with review of literature

Rao¹,

Dsouza²

2015

Int Jour of Biomed Res

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Introduction: Gingivobuccal (GB) complex disease is the most common subsite involved in India hence aptly called as the "Indian Cancer". The widespread use of smokeless tobacco consumption is the main etiological factor. We undertook a study to see the pattern of presentation, evaluation and the treatment offered depending on the disease spread. Materials and methods: Prospective study of 100 patients visiting the outpatient department of Father Muller Medical College, Mangalore suffering from oral cavity cancer with primary involvement of GB complex. Results: The main complaint was presence of an ulcerative lesion followed by foreign body sensation and pain. Lower GB sulcus with involvement of horizontal ramus was commonest presentation. Upfront nodal metastasis was not common. Discussion: GB complex disease has a much greater incidence in women unlike subsites. It's a disease with better prognosis than other subsites hence; early tumors can be effectively managed. Detailed tumor staging and comprehensive disease management protocol has been postulated. Conclusion: Proper staging of the disease with good surgical resection ensures better survival. Team work is the key to good outcome.

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Section: Discussionmentioning

confidence: 99%

Indian cancer: Our experience with review of literature

Rao¹,

Dsouza²

2015

Int Jour of Biomed Res

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“…46 The oral mucosa is blanched with the presence of fibrotic bands which can be palpated commonly in the buccal mucosa, palate, labial mucosa, tongue, and posterior pharynx. 46 The primary etiological agent is areca nut chewing, which by means of reactive oxygen species damages the cells. Further other conditions like vitamin deficiencies, anemia, etc.…”

Section: Role In Oral Submucous Fibrosismentioning

confidence: 99%

“…cause more damage to the inflamed oral mucosa and hinder the healing process, thereby further making the epithelium susceptible to effects of areca. 46 Patients with OSMF usually present in their late stages making the treatment of disease difficult. 46 Ever since the condition has been recognized, the treatment of OSMF has remained a huge enigma.…”

Section: Role In Oral Submucous Fibrosismentioning

confidence: 99%

“…46 Patients with OSMF usually present in their late stages making the treatment of disease difficult. 46 Ever since the condition has been recognized, the treatment of OSMF has remained a huge enigma. A wide range of treatment modalities have been used, however, none have evolved as a promising treatment option.…”

Section: Role In Oral Submucous Fibrosismentioning

confidence: 99%

“…Commonly employed treatment includes medical therapy by use of corticosteroids, placental extracts, hyaluronidase, interferon gamma, and physiotherapy. 44,46 However, considering the adverse effects caused by steroids, interferons, etc., the focus has shifted onto the development of safer modalities of treatment. 42,46,47 The role of minerals and micronutrients in treatment of OSMF has received impetus as they have been observed to bring about significant improvement in mouth opening (41%).…”

Section: Role In Oral Submucous Fibrosismentioning

confidence: 99%

See 2 more Smart Citations

Spirulina: An Emerging Treatment Modality for the Management of Oral Submucous Fibrosis

Desai¹,

Hallikerimath²,

Kale³

2017

IJOCRWEB

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Fibrotic remodeling and tissue regeneration mechanisms define the therapeutic potential of human muscular progenitors

Hsiao

Wang

Yang

2022

Bioengineering & Transla Med

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Fibrosis is an intrinsic biological reaction toward the challenges of tissue injury that is implicated in the wound‐healing process. Although it is useful to efficiently mitigate the damage, progression of fibrosis is responsible for the morbidity and mortality occurring in a variety of diseases. Because of lacking effective treatments, there is an emerging need for exploring antifibrotic strategies. Cell therapy based on stem/progenitor cells is regarded as a promising approach for treating fibrotic diseases. Appropriate selection of cellular sources is required for beneficial results. Muscle precursor cells (MPCs) are specialized progenitors harvested from skeletal muscle for conducting muscle regeneration. Whether they are also effective in regulating fibrosis has seldom been explored and merits further investigation. MPCs were successfully harvested from all human samples regardless of demographic backgrounds. The extracellular matrices remodeling was enhanced through the paracrine effects mediated by MPCs. The suppression effects on fibrosis were confirmed in vivo when MPCs were transplanted into the diseased animals with oral submucous fibrosis. The data shown here revealed the potential of MPCs to be employed to simultaneously regulate both processes of fibrosis and tissue regeneration, supporting them as the promising cell candidates for development of the cell therapy for antifibrosis and tissue regeneration.

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Oral submucous fibrosis: a historical perspective and a review on etiology and pathogenesis

Abstract: Background: Oral submucous fibrosis (OSF) is a chronic, insidious disease characterized by

Cited by 143 publications

References 78 publications

Indian cancer: Our experience with review of literature

Indian cancer: Our experience with review of literature

Spirulina: An Emerging Treatment Modality for the Management of Oral Submucous Fibrosis

Fibrotic remodeling and tissue regeneration mechanisms define the therapeutic potential of human muscular progenitors

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